supported by the National Natural Science Foundation of China,Nos.81970820(to HX),31771644(to JL),31930068(to JL),82371176(to JL),81801331(to LC);National Key Research and Development Project of China.Nos.2017YFA0104100(to JL),2017YFA0701304(to HX);Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)Talent Introduction Plan,No.KYPT202204(to LC);the Fundamental Research Funds for the Central Universities,No.22120230292(to JL)。
Inflammation plays a crucial role in the regeneration of fish and avian retinas.However,how inflammation regulates Müller glia(MG)reprogramming remains unclear.Here,we used single-cell RNA sequencing to investigate t...
supported by the Rural & Environment Science & Analytical Services (RESAS) Division of the Scottish Government through project JHI-B1-1;the Biotechnology and Biological Sciences Research Council (BBSRC) through awards BB/ S015663/1;BB/X009068/1;Research Leaders 2025 fellowship funded by European Union’s Horizon 2020 research and innovation programme under Marie Sklodowska-Curie grant agreement no. 754380;the Research/Scientific Computing teams at The James Hutton Institute and NIAB for providing computational resources and technical support for the “UK’s Crop Diversity Bioinformatics HPC” (BBSRC grant BB/ S019669/1)。
An accurate assessment of host and pathogen gene expression during infection is critical for understanding the molecular aspects of host-pathogen interactions.Often,pathogen-derived transcripts are difficult to ascert...
Supported by Instituto de Salud Carlos III(ISCiii),No.PI19/01266 and No.PI22/00857;Consejería de Salud y Familias(Junta de Andalucía),No.PI-0216-2020 and No.PIP-0215-2020;Biomedical Research Network Center for Liver and Digestive Diseases(CIBERehd)founded by the ISCIII and co-financed by European Regional Development Fund“A way to achieve Europe”ERDF.
BACKGROUND Hepatocellular carcinoma(HCC)is the most common subtype of primary liver cancer with varied incidence and epidemiology worldwide.Sorafenib is still a recommended treatment for a large proportion of patients...
supported by the Polish National Science Center research grants:OPUS 16[grant number:2018/31/B/NZ9/00781];OPUS 20[grant number:2020/39/B/NZ9/01061]and SONATA 16[grant number:2020/39/D/NZ9/01009]。
Background The pituitary belongs to the most important endocrine glands involved in regulating reproductive functions.The proper functioning of this gland ensures the undisturbed course of the oestrous cycle and affec...
the Basic Science Center Program(32288101 to S.X.);the National Natural Science Foundation of China(NSFC)grants(32030020,31771388 and 31961130380to S.X.);the UK Royal Society-Newton Advanced Fellowship(NAFR1191094 to S.X.);the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01 to S.X.)。
It remains unknown and debatable how European-Asian–differentiated alleles affect individual phenotypes.Here,we made the first effort to analyze the expression profiles of highly differentiated genes with eastern and...
the financial support provided by the National Program on Key Research Project of China(2016YFD0500406);the National Natural Sciences Foundation of China(Grant No.31872455);the Fundamental Research Funds for the Central Universities(2662018PY016);the Start-up Research Fund from Huazhong Agricultural University.
Influenza viruses not only cause respiratory illness,but also have been reported to elicit neurological manifestations following acute viral infection.The central nervous system(CNS)has a specific defense mechanism ag...
the Central Publicinterest Scientific Institution Basal Research Fund(1610212020002);the Major Project of Agricultural Science and Technology in Breeding of Tea Plant Variety in Zhejiang Province(2021C02067);Earmarked Fund for China Agriculture Research System(CARS-19).
Albino tea,a type of tea closely associated with the chlorophyll-deficient phenotype is of great interest due to its multiple benefits to human health.To explore the potential mechanisms involved in albino tea,we perf...
supported by National Natural Science Foundation of China(31672687 and 31873046);Natural Science Foundation of Fujian Province(2018J01452).
No studies have systematically compared time-resolved and multi-tissue innate immune responses for European eels(Anguilla anguilla)with Aeromonas hydrophila infection by a high throughput method.Here,we challenged Eur...
This work was supported by Italian Ministery of Health RC 08C921 to LL,Istituto Auxologico Italiano,IRCCs.
Taking advantage of the fast-growing knowledge of RNA-binding proteins(RBPs)we review the signature of downregulated genes for RBPs in the transcriptome of induced pluripotent stem cell neurons(iNeurons)modelling the ...
This work was supported by NIH/NIDCR grants R01DE029173 and R01DE030445 and NIH/NCI grant R01CA236878.
RNA sequencing(RNAseq)can reveal gene fusions,splicing variants,mutations/indels in addition to differential gene expression,thus providing a more complete genetic picture than DNA sequencing.This most widely used tec...