ZEBRAFISH

作品数：499被引量：948H指数：13
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相关领域：生物学更多>>
相关作者：裴得胜刘可春王思锋齐亚德王希敏更多>>
相关机构：中国科学院重庆绿色智能技术研究院中国科学院上海生命科学研究院复旦大学山东省科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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A single-cell landscape of the regenerating spinal cord of zebrafish
《Neural Regeneration Research》2026年第2期780-789,共10页Lei Yao Xinyi Cai Saishuai Yang Yixing Song Lingyan Xing Guicai Li Zhiming Cui Jiajia Chen 
supported by the Jiangsu Province Traditional Chinese Medicine Technology Development Plan Project,Nos.MS2023113(to JC),MS2022090;Young and Middle-aged Academic Leaders of Jiangsu Qing-Lan Project(to GL).
Unlike mammals,zebrafish possess a remarkable ability to regenerate their spinal cord after injury,making them an ideal vertebrate model for studying regeneration.While previous research has identified key cell types ...
关键词：dividing oligodendrocyte macrophage MICROGLIA neuron proliferating oligodendrocyte radial glia single cell sequencing spinal cord regeneration transcriptome ZEBRAFISH 
Zebrafish optic nerve regeneration involves resident and retinal oligodendrocytes
《Neural Regeneration Research》2026年第2期811-820,共10页Cristina Pérez-Montes Rosalía Hernández-García Jhoana Paola Jiménez-Cubides Laura DeOliveira-Mello Almudena Velasco Rosario Arévalo Marina García-Macia Adrián Santos-Ledo 
supported by the Lanzadera TCUE and C2 program(Universidad de Salamanca)(to ASL);the Spanish National Research Council(CSIC)funded by the Junta de Castilla y León and co-financed by the European Regional Development Fund(ERDF“Europe drives our growth)”:Internationalization Project“CL-EI-2021-08-IBFG Unit of Excellence”,Grant(PID2022-138478OA-100)funded by MICIU/AEI/10.13039/501100011033 and,by FEDER,UE(to MGM);Junta de Castilla y León(SA225P23)and Gerencia Regional de Salud(2701/A1/2023)(to AV);the Plan Especial Grado Medicina(USAL)(to CPM);a Ramón y Cajal researcher:Grant RYC2021-033684-I funded by MICIU/AEI/10.13039/501100011033 and,by European Union NextGenerationEU/PRTR.
The visual system of teleost fish grows continuously,which is a useful model for studying regeneration of the central nervous system.Glial cells are key for this process,but their contribution is still not well define...
关键词：cell death OLIGODENDROCYTES optic nerve proliferation regeneration Sox10 SOX2 visual system ZEBRAFISH 
Single-cell RNA sequencing reveals the heterogeneity and interactions of immune cells and Müller glia during zebrafish retina regeneration
《Neural Regeneration Research》2025年第12期3635-3648,共14页Hui Xu Lining Cao Yuxi Chen Cuiping Zhou Jie Xu Zhuolin Zhang Xiangyu Li Lihua Liu Jianfeng Lu 
supported by the National Natural Science Foundation of China,Nos.81970820(to HX),31771644(to JL),31930068(to JL),82371176(to JL),81801331(to LC);National Key Research and Development Project of China.Nos.2017YFA0104100(to JL),2017YFA0701304(to HX);Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)Talent Introduction Plan,No.KYPT202204(to LC);the Fundamental Research Funds for the Central Universities,No.22120230292(to JL)。
Inflammation plays a crucial role in the regeneration of fish and avian retinas.However,how inflammation regulates Müller glia(MG)reprogramming remains unclear.Here,we used single-cell RNA sequencing to investigate t...
关键词：immune cells inflammation Jak1-Stat3 signaling microglia Müller glia REGENERATION reprogramming RETINA single-cell RNAseq ZEBRAFISH 
Telencephalic stab wound injury induces regenerative angiogenesis and neurogenesis in zebrafish:unveiling the role of vascular endothelial growth factor signaling and microglia
《Neural Regeneration Research》2025年第10期2938-2954,共17页Danielle Fernezelian Philippe Rondeau Laura Gence Nicolas Diotel 
supported by European Regional Development Funds RE0022527 ZEBRATOX(EU-Région Réunion-French State national counterpart,to Nicolas Diotel and Jean-Loup Bascands).
After brain damage,regenerative angiogenesis and neurogenesis have been shown to occur simultaneously in mammals,suggesting a close link between these processes.However,the mechanisms by which these processes interact...
关键词：ANGIOGENESIS cerebral damage inflammation NEUROGENESIS stab wound TELENCEPHALON vascular endothelial growth factor ZEBRAFISH 
Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons
《Neural Regeneration Research》2025年第6期1816-1824,共9页Jiantao Cui Yueru Shen Zheng Song Dinggang Fan Bing Hu 
supported by the Research Funds of the Center for Advanced Interdisciplinary Science and Biomedicine of IHM,No.QYZD20220002;the National Natural Science Foundation of China,No.82071357;a grant from the Ministry of Science and Technology of China,No.2019YFA0405600 (all to BH)。
Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles an...
关键词：axonal regeneration Mauthner cell nerve regeneration Rab5 ZEBRAFISH 
Tnni3k regulates cardiomyopathy and cardiac conduction disease through Nfatc1 signaling
《Genes & Diseases》2025年第3期50-53,共4页Shi Ouyang Yujuan Niu Le Liu Qiaorong Yi Wuming Qin Hui Cao Tao Liao Rong Xiang Yonghe Ding Yun Deng 
supported in part by the National Natural Science Foundation of China(No.31970504,31772548,82371863,82070394);the NHC Key Laboratory of Birth Defect for Research and Prevention(Hunan Provincial Maternal and Child Health Care Hospital)(No.KF2021003);the Postgraduate Scientific Innovation Fund of Hunan Province,China(No.CX2018B302).
TNNI3K(troponin-I interacting kinase)encodes a duo tyrosine and serine/threonine kinase implicated in cardiomyopathy,arrhythmias,and cardiac conduction disease(CCD).1 However,no direct downstream phosphorylation targe...
关键词：generate splicing mutation splicing mutation zebrafish tnni k ortholog gene tnni k direct downstream phosphorylation targets cardiac conduction disease ccd CARDIOMYOPATHY nfatc signaling 
Zebrafish as a preclinical model for diabetes mellitus and its complications:From monogenic to gestational diabetes and beyond
《World Journal of Diabetes》2025年第5期31-46,共16页Jie Huang Yin-Ling Chen 
Supported by Natural Science Foundation of Zhejiang Province,China,No.LQ24H070007。
With diabetes currently affecting 537 million people globally,innovative research approaches are urgently required.Zebrafish(Danio rerio)has emerged as a pivotal model organism in diabetes research,particularly valuab...
关键词：ZEBRAFISH Preclinical model Diabetes mellitus Monogenic diabetes Gestational diabetes 
Phenanthrene perturbs hematopoietic development and causes hematopoietic defects in zebrafish
《Journal of Environmental Sciences》2025年第5期573-581,共9页Lingyu Ren Yue Wang Ying Ren Guangke Li Nan Sang 
supported by the National Natural Science Foundation of China(Nos.22276117 and 22076108);the Science and Technology Innovation Talent Team Project of Shanxi Province(No.202204051002024).
Phenanthrene(Phe)is one of the common polycyclic aromatic hydrocarbons in the environment,and recent studies show that it can cause cardiac developmental toxicity and immunotoxicity.However,it is still unknown whether...
关键词：PHENANTHRENE ZEBRAFISH Hematopoietic development Hematopoietic defect 
Esculetin triggers ferroptosis via inhibition of the Nrf2-xCT/GPx4 axis in hepatocellular carcinoma
《Chinese Journal of Natural Medicines》2025年第4期443-456,共14页Zhixin Qu Jing Zeng Laifeng Zeng Xianmei Li Fenghua Zhang 
supported by the Natural Science Foundations of Fujian Province(Nos.2021J05063 and 2023J01541);a startup grant for High-level Talents of Fujian Medical University(No.XRCZX2021014)。
Esculetin,a natural dihydroxy coumarin derived from the Chinese herbal medicine Cortex Fraxini,has demonstrated significant pharmacological activities,including anticancer properties.Ferroptosis,an iron-dependent form...
关键词：ESCULETIN Ferroptosis Hepatocellular carcinoma Nrf2-xCT/GPx4 axis ZEBRAFISH 
The circadian clock orchestrates spermatogonial differentiation and fertilization by regulating retinoic acid signaling in vertebrates
《National Science Review》2025年第3期134-152,共19页Taole Liu Wei He Zhaomin Zhong Chenchen Lu Lianxin Wu Ziming Wang William Kojo Smith Quan Shi Qiaoming Long Han Wang 
supported by the National Key R&D Program of China(2019YFA0802400 and 2018YFA0801000);the National Basic Research Program of China(2012CB947600);the National Natural Science Foundation of China(31961133026,31871187,31030062,81570171 and 81070455);the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
The circadian clock generates and maintains~24-hour oscillations in almost all organs.The testis,however,remains mysterious,without a clear understanding of its circadian functions.Our time-series transcriptome analys...
关键词：TESTIS circadian clock SPERMATOGENESIS FERTILIZATION retinoic acid ZEBRAFISH mice 
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