ESCULETIN

作品数：10被引量：38H指数：4
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相关领域：医药卫生更多>>
相关作者：曾尤超刘涛更多>>
相关机构：遵义医学院附属医院遵义医学院昆明医科大学更多>>
相关期刊：《中国老年学杂志》《Asian Pacific Journal of Tropical Medicine》《Food Bioscience》《Chinese Herbal Medicines》更多>>
相关基金：国家自然科学基金更多>>
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Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration
《Acta Pharmacologica Sinica》2025年第1期52-65,共14页Jia-qi He Ruo-lan Yuan Yu-tong Jiang Ye Peng Jun-rui Ye Sha-sha Wang Li-qing Li Yuan Ruan Pei-yi Li Xu Yan Wen-bin He Gang Li Shi-feng Chu Zhao Zhang Nai-hong Chen 
This work was supported by the National Key R&D Program of China(2022YFC3500300);National Natural Science Foundation of China(U2202214,82074044,82374060,82130109,U21A20410);the CAMSInnovationFund for Medical Sciences(CIFMS)(2021-I2M-1-020).
Esculetin(ESC)is a coumarin-derived phytochemical prevalent in traditional Chinese medicine that exhibits anti-acute ischemic stroke activities.Our previous studies demonstrate that CKLF1 is a potential anti-stroke ta...
关键词：ischemic stroke ESCULETIN COUMARIN neutrophil infiltration CKLF1 CCR5 
Bioactive coumarin-derivative esculetin decreases hepatic stellate cell activation via induction of cellular senescence via the PI3K-Akt-GSK3βpathway
《Food Bioscience》2022年第6期1866-1875,共10页Mengfan Zhang Turtushikh Damba Zongmei Wu Sandra Serna-Salas Manon Buist-Homan Klaas Nico Faber Han Moshage 
Supported by a grant from the Chinese Scholarship Council;Supported by a grant from the Mongolian State Training Foundation。
Background Activation of hepatic stellate cells(HSC)leads to initiation and progression of hepatic fibrosis.HSC senescence is inversely correlated with HSC proliferation and activation.Therefore,induction of HSC senes...
关键词：Fibrosis ESCULETIN Hepatic stellate cell Senescence P21 Akt 
Difference analysis of different parts of chicory based on HPLC fingerprint and multi-component content determination被引量：3
《Chinese Herbal Medicines》2022年第2期317-323,共7页Mengzhen Yan Zhenling Zhang Yanze Liu 
financial support of the industry special project for the public welfare of the State Administration of Traditional Chinese Medicine of China(00104296)。
Objective:To establish HPLC fingerprints of different parts of chicory stems,leaves,roots,flowers and seeds,and compare the similarities and differences of chemical components in different parts,so as to provide a sci...
关键词：caffeic acid cichoric acid CHICORY chlorogenic acid ESCULETIN fingerprint HPLC HYPEROSIDE isochlorogenic acid C LUTEOLIN multi-component content determination RUTIN 
Esculetin protects against early sepsis via attenuating inflammation by inhibiting NF-κB and STAT1/STAT3 signaling被引量：13
《Chinese Journal of Natural Medicines》2021年第6期432-441,共10页CHENG Yao-Jun TIAN Xin-Lei ZENG Ya-Zhi LAN Nan GUO Ling-Feng LIU Ke-Feng FANG Hui-Long FAN Hong-Ye PENG Zhong-Lu 
supported by the Key Project of Scientific Research Fund of Hunan Provincial Education Department(15A177);the Natural Science Foundation of Hunan Province(2019JJ40275).
Esculetin,a natural derivative from the traditional and widely-used Chinese medicinal herb Cortex Fraxini,has a variety of pharmacological effects,especially in anti-inflammation.However,it is not clear whether escule...
关键词：ESCULETIN NF-ΚB STAT1 STAT3 Early sepsis 
Effect of esculetin on bone metabolism in ovariectomized rats被引量：1
《Journal of Traditional Chinese Medicine》2018年第6期896-903,共8页Liu Meijie Wang Ruihai Li Yan Bai Dong Pan Jinghua Liu Hong Wang Shaojun Wu Jiaying Sun Gang Miao Qing Ju Dahong Liu Limei 
Supported by Independent Subject Selection Project of the China Academy of Chinese Medical Sciences:Research on the New Function of Cortex Fraxini in the Treatment of Osteoporosis(No.YZ-1411)
OBJECTIVE: To determine the effect of an esculetin formulation(at 97.4% purity) on osteoporosis, and to investigate the potential underlying molecular mechanism(s).METHODS: Sixty specific pathogen free-grade female Wi...
关键词：ESCULETIN OSTEOPOROSIS OSTEOPROTEGERIN RANK LIGAND Bone RESORPTION 
Esculetin对缺血性脑损伤大鼠神经的保护作用被引量：5
《中国老年学杂志》2018年第12期2999-3001,共3页曾尤超 姜芮 刘涛 范瑞明 
遵义市科技计划课题任务书(遵市科合社字[2013]44号)
目的探讨Esculetin(ESC)对缺血性脑损伤大鼠的神经保护作用及可能机制。方法通过线栓法建立大鼠脑缺血再灌注模型,并对大鼠神经功能进行评分;将大鼠模型均分为ESC处理组和模型组,其中ESC处理组大鼠通过灌胃给予ESC,而模型组给予等量的...
关键词：ESCULETIN 缺血性脑损伤 神经保护 
Anti-Alzheimer's disease potential of coumarins from Angelica decursiva and Artemisia capillaris and structure-activity analysis被引量：2
《Asian Pacific Journal of Tropical Medicine》2016年第2期101-108,共8页Md.Yousof Ali Susoma Jannat Hyun Ah Jung Ran Joo Choi Anupom Roy Jae Sue Choi 
supported by the Basic Science Research Program through the National Research Foundation of Korea;funded by the Ministry of Science,ICT&Future Planning(grant No.2014R1A1A3051684 and 2012R1A6A1028677)
Objective: To use structure-activity analysis to study the anti-Alzheimer's disease(anti-AD) activity of natural coumarins isolated from Angelica decursiva and Artemisia capillaries, along with one purchased coumarin(...
关键词：UMBELLIFERONE 6-carboxylic acid ESCULETIN DAPHNETIN COUMARINS CHOLINESTERASE BACE1 
Molecularly imprinted polymer for pre-concentration of esculetin from tobacco followed by the UPLC analysis被引量：2
《Science China Chemistry》2014年第12期1751-1759,1-2,共9页RAZWAN SARDAR M. JIN Yan KONG Guang Hui LI Hai Fang LIN Jin-Ming 
supported by the Yunnan Green Tobacco Production Research(2011YN01);the China Equipment and Education Resources System(CERS-1-75)
Molecularly imprinted polymers(MIPs)for solid-phase extraction and pre-concentration of esculetin have been successfully prepared by the bulk polymerization method using esculetin as a template molecule.Polymers of va...
关键词：molecularly imprinted polymer ESCULETIN TOBACCO UPLC 
Protective effect of esculetin against oxidative stress-induced cell damage via scavenging reactive oxygen species被引量：4
《Acta Pharmacologica Sinica》2008年第11期1319-1326,共8页So-hyung KIM Kyoung-ah KANG Rui ZHANG Mei-jing PIAO Dong-ok KO Zhi-hong WANG Sung-wook CHAE Sam-sik KANG Keun-hwa LEE Hee-kyoung KANG Hyun-wook KANG Jin-won HYUN 
Aim： To investigate the anti-oxidant properties of esculetin （6,7-dihydroxycoumarin） against H2O2-induced Chinese hamster lung fibroblast （V79-4） damage. Methods： The radical scavenging activity was assessed by ...
关键词：anti-oxidant activity ESCULETIN oxidative stress cytoprotective activity reactive oxygen species 
Immunomodulatory Effects of Esculetin(6,7-Dihydroxycoumarin)on Murine Lymphocytes and Peritoneal Macrophages被引量：11
《Cellular & Molecular Immunology》2005年第3期181-188,共8页Kwok-nam Leung Dr.Kwok-nam Leung Pui-yinLeung Lai-pingKong Po-kiLeung 
Coumarins belong to a diverse group of naturally occurring non-nutrient phytochemicals known as benzo-α- pyrones. In this study, esculetin, a 6,7-dihydroxy derivative of coumarin with pleiotropic biological activitie...
关键词：IMMUNOMODULATORY ESCULETIN COUMARIN murine macrophage LAK cell 
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