COUMARINS

作品数：64被引量：98H指数：6
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相关领域：理学医药卫生更多>>
相关作者：楼之岑刘治安果德安秦路平黄矛更多>>
相关机构：北京医科大学第二军医大学湖北医药学院富山医科药科大学更多>>
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Artemisia: A Comprehensive Review of Phytochemistry, Medicinal Properties, and Biological Activities
《Journal of Biosciences and Medicines》2024年第11期524-537,共14页Noorah Saleh Al-Sowayan Fayafi Al-Harbi Shouaa Abdulaziz Alrobaish 
This review provides a comprehensive overview of the phytochemistry, medicinal properties, and biological activities of the Artemisia species. Artemisia species exhibit a wide range of morphological and phytochemical ...
关键词：Essential Oils Artemisinin ANTIMALARIAL Bioactivity TERPENOIDS Flavonoids COUMARINS STEROLS ACETYLENES 
The chromosome-scale assembly of the Notopterygium incisum genome provides insight into the structural diversity of coumarins
《Acta Pharmaceutica Sinica B》2024年第8期3760-3773,共14页Qien Li Yiqun Dai Xin-Cheng Huang Lanlan Sun Kaixuan Wang Xiao Guo Dingqiao Xu Digao Wan Latai An Zixuan Wang Huanying Tang Qi Qi Huihui Zeng Minjian Qin Jia-Yu Xue Yucheng Zhao 
supported by the Western Light Project of the Chinese Academy of Sciences and the Young Qihuang Scholars Project of the National Administration of Traditional Chinese Medicine.This research was also funded by the open foundation of Shaanxi University of Chinese Medicine state key laboratory of R&D of Characteristic Qin Medicine Resources(SUCM-QM202202,China);the fund of Traditional Chinese Medicine Institute of Anhui Dabie Mountain(TCMADM-2023-18,China);“Double FirstClass”University Project of China Pharmaceutical University(CPU2022QZ27,China);supported by the key project at the central government level:the ability establishment of sustainable use for valuable Chinese medicine resources(2060302,China);the open research fund of Yunnan characteristic plant extraction laboratory(YKKF2023002,China)。
Coumarins,derived from the phenylpropanoid pathway,represent one of the primary metabolites found in angiosperms.The alignment of the tetrahydropyran(THP)and tetrahydrofuran(THF)rings with the lactone structure result...
关键词：Notopterygium incisum Parallel evolution BIOSYNTHESIS Pyranocoumarins FURANOCOUMARINS 
Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis
《Chinese Journal of Natural Medicines》2024年第7期643-653,共11页DANG Wen GUO Tingting ZHOU Di MENG Qingqi FANG Mingxia CHEN Gang LIN Bin HOU Yue LI Ning 
supported by the National Natural Science Foundation of China(No.U1903122);the Scientific Research Fund of Liaoning Province Education Department(No.LJKZ0945);the Natural Science Foundation of Liaoning Province(No.2022-MS-242).
The resin of Ferula sinkiangensis has been traditionally utilized for treating gastrointestinal disorders,inflammation,tumors,various cancers,and alopecia areata.The primary bioactive constituents,sesquiterpene coumar...
关键词：Ferula sinkiangensis Sesquiterpene coumarins Structure elucidation Anti-neuroinflammatory activity 
Two types of coumarins-specific enzymes complete the last missing steps in pyran- and furanocoumarins biosynthesis被引量：1
《Acta Pharmaceutica Sinica B》2024年第2期869-880,共12页Yucheng Zhao Yuedong He Liangliang Han Libo Zhang Yuanzheng Xia Fucheng Yin Xiaobing Wang Deqing Zhao Sheng Xu Fei Qiao Yibei Xiao Lingyi Kong 
National Key Research and Development Program of China (2018YFA0902000);the key project at central government level:the ability establishment of sustainable use for valuable Chinese medicine resources(2060302,China);the open foundation of Shaanxi University of Chinese Medicine state key laboratory of R&D of Characteristic Qin Medicine Resources (SUCM-QM202202,China);the fund of Traditional Chinese Medicine Institute of Anhui Dabie Mountain (TCMADM-2023-18,China);National Natural Science Foundation of China (32070364);Hainan Provincial Natural Science Foundation of China(2019RC309)
Pyran-and furanocoumarins are key representatives of tetrahydropyrans and tetrahydrofurans,respectively,exhibiting diverse physiological and medical bioactivities.However,the biosynthetic mechanisms for their core str...
关键词：TETRAHYDROPYRANS TETRAHYDROFURANS Baldwin rules COUMARINS CYP450cyclase 
Six new coumarins from the roots of Toddalia asiatica and their anti-inflammatory activities
《Chinese Journal of Natural Medicines》2023年第11期852-858,共7页HE Haoxuan LI Niping FAN Yunqi HUANG Qian SONG Jianguo LV Lixia LIU Fen WANG Lei WANG Qi GU Jihong 
supported financially by the National Natural Science Foundation of China(No.82104014 and 82003605);the Key Laboratory Project of Colleges and Universities in Guangdong Province(No.2019KSYS005);the Guangdong Province Science and Technology Plan International Cooperation Project(No.2020A0505100052)。
We reported the discovery of six novel coumarins, toddasirins A–F ( 1 – 6 ), each endowed with modified isoprenyl or geranyl side chains, derived from the roots of Toddalia asiatica. Comprehensive structural elucida...
关键词：Toddalia asiatica COUMARINS Anti-inflammatory effects RAW 264.7 cells 
Molecular Docking Studies of Estrone-Coumarin Derivatives as Aromatase and 17β-HSD1 Inhibitors Related to Hormone Receptor Positive (HR+) Breast Cancer
《Advances in Enzyme Research》2022年第4期83-100,共18页Silvia Alejandra Meza-Ireta Blanca Colin-Lozano Penélope Merino-Montiel José Luis Vega-Báez Sara Montiel-Smith 
Hormone Receptor positive (HR+) breast cancer is the most common malignancy in women. New strategies in the treatments have targeted the estrogen biosynthesis pathways including the inhibition of the aromatase and 17...
关键词：ESTRONE COUMARINS Aromatase Inhibitors 17β-HSD1 Inhibitors Molecular Docking 
Glycoside-specific metabolomics combined with precursor isotopic labeling for characterizing plant glycosyltransferases被引量：8
《Molecular Plant》2022年第10期1517-1532,共16页Jie Wu Wentao Zhu Xiaotong Shan Jinyue Liu Lingling Zhao Qiao Zhao 
the National Key R&D Program of China(2019YFA0903900);National Natural Science Foundation of China(grant number 31870273);Guangdong Provincial Key Laboratory of Synthetic Genomics(2019B030301006);Shenzhen Key Laboratory of Synthetic Genomics(ZDSYS201802061806209);Shenzhen Instituteof Synthetic Biology Scientific Research Program(ZTXM20190007).
Glycosylation by uridine diphosphate-dependent glycosyltransferases(UGTs)in plants contributes to the complexity and diversity of secondary metabolites.UGTs are generally promiscuous in their use of acceptors,making i...
关键词：GLYCOSYLTRANSFERASES glycosides-specific metabolomics precursor isotopic labeling glucoside Arabidopsis thaliana PHENYLPROPANOID COUMARINS 
The synthesis of tetracyclic coumarins via decarboxylative asymmetric[4+2]cycloadditions enabled by Pd(0)/Cu(I)synergistic catalysis
《Chinese Journal of Catalysis》2022年第7期1812-1817,共6页Kai Wang Xiangfeng Lin Qian Li Yan Liu Can Li 
国家自然科学基金(21871254);大连化物所自主部署基金(DICP ZZBS201602);中国科学院王宽诚率先人才计划(GJTD-2020-08).
Tetracyclic coumarins are a class of important compounds with diverse and superior pharmacolog‐ical activities.However,a direct stereoselective method from simple and readily‐made coumarins derivatives remains chall...
关键词：Synergistic catalysis Pd(0)/Cu(I)catalysis Asymmetric catalysis [4+2]Cycloaddition Tetracyclic coumarins Chiral catalysis 
A Semi-Vectorial Morphological Segmentation Multi-Component Images of Coumarins on Thin Layer Combined with Laser for Better Separation
《Open Journal of Applied Sciences》2022年第6期1054-1068,共15页Theodore Guié Toa Bi Marcelin Sandjé Régnima G. Oscar Sie Ouattara Alain Clement 
In this work, we propose an approach for the separation of coumarins from thin-layer morphological segmentation based on the acquisition of multicomponent images integrating different types of coumarins. The first ste...
关键词：Identification Thin Layer Secondary Metabolites COUMARINS Image Acquisition Segmentation Standard Deviation ENTROPY Average Color Algorithm Matlab 
Three new coumarins and a new coumarin glycoside from Micromelum integerrimum
《Chinese Journal of Natural Medicines》2021年第8期621-625,共5页CAO Nan-Kai CHEN Yue-Mei ZHU Si-Si ZENG Ke-Wu ZHAO Ming-Bo LI Jun TU Peng-Fei JIANG Yong 
supported by the National Natural Sciences Foundation of China(Nos.81973199,81773864 and81473106);the Drug Innovation Major Project of China(No.2018ZX09711001-008-003)。
Three new coumarins,integmarins A–C(1–3),and a new coumarin glycoside,integmaside A(4)were isolated from the leaves and stems of Micromelum integerrimum.Their structures were elucidated on the basis of 1 D and 2 D N...
关键词：RUTACEAE Micromelum integerrimum COUMARINS Coumarin glycoside ECD 
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