Three new coumarins and a new coumarin glycoside from Micromelum integerrimum  

作　　者：CAO Nan-Kai CHEN Yue-Mei ZHU Si-Si ZENG Ke-Wu ZHAO Ming-Bo LI Jun TU Peng-Fei JIANG Yong 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China

出　　处：《Chinese Journal of Natural Medicines》2021年第8期621-625,共5页中国天然药物（英文版）

基　　金：supported by the National Natural Sciences Foundation of China(Nos.81973199,81773864 and81473106);the Drug Innovation Major Project of China(No.2018ZX09711001-008-003)。

摘　　要：Three new coumarins,integmarins A–C(1–3),and a new coumarin glycoside,integmaside A(4)were isolated from the leaves and stems of Micromelum integerrimum.Their structures were elucidated on the basis of 1 D and 2 D NMR and MS data,and their absolute configurations were assigned according to the ECD data of the in situ formed transition metal complexes and comparison of experimental and calculated ECD data.Compounds 1 and 2 are two rare coumarins with butyl and propyl moieties at the C-6 position;compound 3 is a novel coumarin with a highly oxidized prenyl group,and compound 4 is a rare bisdihydrofuranocoumarin glycoside.

关 键 词：RUTACEAE Micromelum integerrimum COUMARINS Coumarin glycoside ECD 

分 类 号：R284[医药卫生—中药学] R965[医药卫生—中医学]