This review provides a comprehensive overview of the phytochemistry, medicinal properties, and biological activities of the Artemisia species. Artemisia species exhibit a wide range of morphological and phytochemical ...
YIKI is an antimalarial phytomedicine used by a traditional healer to treat malaria in Bobo-Dioulasso. However, there is no scientific evidence to support its use by local populations. The aim of this study was to ide...
supported by grants from the National Key Research and Development Program of China(Nos.2020YFA0908000 and 2022YFC2303600);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-C-202002);the National Natural Science Foundation of China(Nos.82141001,82274182,82074098 and 82173914);the CACMS Innovation Fund(Nos.CI2021A05101 and CI2021A05104);:the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021B014);the Science and Technology Foundation of Shenzhen(No.JCYj20210324115800001);the Science and Technology Foundation of Shenzhen(Shenzhen Clinical Medical Research Center for Geriatric Diseases);Establishment of Sino-Austria"Belt and Road"Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research(No.2020YFE0205100);the Fundamental Research Funds for the Central Public Welfare Research Institutes(Nos.ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-YQ-052,ZZ14-FL-002,ZZ14-ND-010 and ZZ15-ND-10);Introduce innovative team projects of Jinan(No.202228029);Shenzhen Governmental Sustainable Development Fund(No.KCXFZ20201221173612034);Shenzhen Key Laboratory of Kidney Diseases(No.ZDSYS201504301616234);Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties(No.SZGSPO01).
Present research on the antimalarial mechanisms of artemisinin(ART)is mainly focused on covalent drug binding targets alkylated by free radicals,while non-covalent binding targets have rarely been reported.Here,we dev...
Six new ent-abietane diterpenoids,abientaphlogatones A−F(1−6),along with two undescribed ent-abietane diterpenoid glucosides,abientaphlogasides A−B(7−8)and four known analogs were isolated from the aerial parts of Phl...
Background: Malaria remains a major cause of morbidity and mortality in Zambia, affecting all levels of society, with children under the age of five and pregnant women being most at risk of serious illness. The availa...
Artemisinins tested against W-2 strains of malaria falciparum are investigated with molecular electrostatic potential (MEP), in an attempt to identify key features of the compounds that are necessary for their activit...
N-11-azaartemisinins potentially active against Plasmodium falciparum are designed by combining molecular electrostatic potential (MEP), ligand-receptor interaction, and models built with supervised machine learning m...
suppor ted by the National Key Research and Development Program of China(2020YFA0908000);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202002);the National Natural Science Foundation of China(82074098,82003814);the CACMS Innovation Fund(CI2021A05101);the Fundamental Research Funds for the Central public welfare research institutes(ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-ND-010,ZZ15-ND-10 and ZZ14-FL-002)。
Background: Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine(CQ) has played an i...
Discovering potent drug candidates requires new antimalarial targets.For this reason,antimalarial drug researchers focus on developing new drug candidates on promising targets.In the identification of these targets,a ...
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