CHLOROQUINE

作品数：83被引量：870H指数：11
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相关领域：医药卫生更多>>
相关作者：刘芳陈淑珍商悦魏富鑫李晋更多>>
相关机构：中国医学科学院北京协和医学院复旦大学中山大学附属第一医院中山大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划江苏省自然科学基金更多>>
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The Role of Oral Chloroquine Treatment in the Home-Based Management of Childhood Malaria in Jos, Nigeria: Biochemical, Hematological, Nutritional, and Co-Infection Perspectives
《Advances in Infectious Diseases》2024年第4期822-837,共16页Segun Afolabi Olomu Samuel Yusuf Gazuwa Titilayo Johnson Selina Nnuaku Okolo 
Research Background: Malaria, predominantly caused by Plasmodium falciparum, continues to be a leading cause of morbidity and mortality among children under five years of age in sub-Saharan Africa. Malaria remains a s...
关键词：Plasmodium falciparum Oral Chloroquine CO-MORBIDITY PARASITEMIA Hematological Markers Biochemical Indices 
Correction to:Low-dose chloroquine treatment extends the lifespan of aged rats
《Protein & Cell》2024年第4期313-313,共1页
This is a correction to:Wei Li,Zhiran Zou,Yusheng Cai,Kuan Yang,Si Wang,Zunpeng Liu,Lingling Geng,Qun Chu,Zhejun Ji,Piu Chan,Guang-Hui Liu,Moshi Song,Jing Qu,Weiqi Zhang,Low-dose chloroquine treatment extends the life...
关键词：CORRECTION TREATMENT LIFE 
Worldwide research trends on chloroquine:a bibliometric analysis from 2012 to 2021
《Traditional Medicine Research》2023年第12期11-22,共12页Lei Xu Qi-Han Zhu Yang Zhao Ming Xiong Si He Yao-Na Xu Chen-Xi Liu Xiao-Fei Hu 
the Natural Science Foundation of Chongqing(Grant No.cstc2021jcyj-msxmX0148);Chongqing Key Clinical Specialty Construction Project(No.CQZDZK007);Beijing University of Chinese Medicine"Exploration and Practice of the Teaching Model of"Three Harmonics"in Mathematics and Physics in Medical Colleges"(JY21024);Beijing University of Chinese Medicine"Junling Hou Teaching Master Workshop"(MSGZF-202001);Beijing University of Chinese Medicine"Research on the Experimental Teaching of Electrical Engineering and Electronics Based on the Thought of Integrating Chinese Medicine"(XJY22024).
Background:Chloroquine(CQ)is an antimalarial drug that was first synthesized by Hans Andersag,a German scientist,in 1934.Chloroquine has been widely researched and used over the years.The rapid development in the fiel...
关键词：BIBLIOMETRICS CHLOROQUINE vosviewer CITESPACE NETWORK HOTSPOT 
Chloroquine enhances the efficacy of chemotherapy drugs against acute myeloid leukemia by inactivating the autophagy pathway被引量：1
《Acta Pharmacologica Sinica》2023年第11期2296-2306,共11页Han-lin Wang Jia-nan Li Wei-juan Kan Gao-ya Xu Guang-hao Luo Ning Song Wen-biao Wu Bo Feng Jing-feng Fu Yu-tong Tu Min-min Liu Ran Xu Yu-bo Zhou Gang Wei Jia Li 
supported by National Natural Science Foundation of China(81821005);Guangdong High-level New R&D Institute(2019B090904008);Guangdong High-level Innovative Research Institute(2021B0909050003);Science and Technology Commission of Shanghai Municipality(18431907100 and 19430750100).
Current therapy for acute myeloid leukemia (AML) is largely hindered by the development of drug resistance of commonly used chemotherapy drugs, including cytarabine, daunorubicin, and idarubicin. In this study, we inv...
关键词：acute myeloid leukemia CYTARABINE DAUNORUBICIN IDARUBICIN drug resistant multi-omics AUTOPHAGY chloroquine phosphate 
Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA被引量：1
《Military Medical Research》2023年第1期64-77,共14页Peng Gao Yan-Qing Liu Wei Xiao Fei Xia Jia-Yun Chen Li-Wei Gu Fan Yang Liu-Hai Zheng Jun-Zhe Zhang Qian Zhang Zhi-Jie Li Yu-Qing Meng Yong-Ping Zhu Huan Tang Qiao-Li Shi Qiu-Yan Guo Ying Zhang Cheng-Chao Xu Ling-Yun Dai Ji-Gang Wang 
suppor ted by the National Key Research and Development Program of China(2020YFA0908000);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202002);the National Natural Science Foundation of China(82074098,82003814);the CACMS Innovation Fund(CI2021A05101);the Fundamental Research Funds for the Central public welfare research institutes(ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-ND-010,ZZ15-ND-10 and ZZ14-FL-002)。
Background: Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine(CQ) has played an i...
关键词：CHLOROQUINE ANTIMALARIA Activity-based protein profiling(ABPP) Cellular thermal shift assay(CETSA) Quantitative proteomics 
Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy被引量：1
《Acta Pharmaceutica Sinica B》2023年第1期327-343,共17页Zimo Liu Xuefei Zhou Qi Li Youqing Shen Tianhua Zhou Xiangrui Liu 
supported by the National Natural Science Foundation of China(Nos.32101128,21975218,and 51773176);the National Key Research and Development Program of China(2019YFA0802202);the 111 Project(B13026,China)。
Extended circulation of anticancer nanodrugs in blood stream is essential for their clinical applications.However,administered nanoparticles are rapidly sequestered and cleared by cells of the mononuclear phagocyte sy...
关键词：TRAIL FIBROBLAST NANOPARTICLES Mononuclear phagocyte system Membrane coating CHLOROQUINE Cancer therapy Drug delivery 
Ethical review of off-label drugs during the COVID-19 pandemic
《World Journal of Clinical Cases》2022年第17期5541-5550,共10页Qiu-Yu Li Ye Lv Zhuo-Yu An Ni-Ni Dai Xue Hong Yu Zhang Li-Jun Liang 
Supported by National Natural Science Foundation of China,No.81900641;Peking University Health Center for Combating the Pandemic Programs,No.BMU 2021MX020,and No.BMU 2022MX008.
High-quality scientific research is very important in attempting to effectively control the coronavirus disease 2019(COVID-19)pandemic and ensure people’s health and safety.Chloroquine(CQ)and hydroxychloroquine(HCQ)h...
关键词：COVID-19 OFF-LABEL CHLOROQUINE HYDROXYCHLOROQUINE 
Investigation of Plasmodium falciparum Resistance Biomarkers among Primary School Children in Western Kenya
《American Journal of Molecular Biology》2022年第2期43-53,共11页Otilmoi Poul Stephen Tonny Teya Nyandwaro Robinson Mugasiali Irekwa Rebecca Wanjiku Waihenya Matthew Mutinda Munyao Peter Kipkemboi Rotich Caroline Wangui Njoroge Anne Wanjiru Mwangi Joanne Jepkemei Yego Nicole Sian Tanchu Dawala Koromtili Oumar Grace Ngendo Kanyita Primrose Muthoni Ndungu Samson Muuo Nzou 
Background: A marked decrease in malaria-related deaths worldwide has been attributed to the administration of effective antimalarials against Plasmodium falciparum. However, the continuous spread of P. falciparum res...
关键词：P. falciparum CHLOROQUINE Drug Resistance MALARIA P. falciparum Chloroquine Resistance Transporter Gene MUTATIONS 
Low-dose chloroquine treatment extends the lifespan of aged rats被引量：1
《Protein & Cell》2022年第6期454-461,共8页Wei Li Zhiran Zou Yusheng Cai Kuan Yang Si Wang Zunpeng Liu Lingling Geng Qun Chu Zhejun Ji Piu Chan Guang-Hui Liu Moshi Song Jing Qu Weiqi Zhang 
the National Key Research and Development Program of China(2018YFC2000100);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16000000);the Program of Beijing Municipal Science and Technology Commission(Z191100001519005);the National Natural Science Foundation of China(Grant Nos.81921006,8162500991749202,81861168034,91949209,92049304,81822018,81870228,81922027,82071588,92049116,31801010,81901433,82125011,82122024,92149301,92168201);the National Key Research and Development Program of China(2020YFA0804000,2020YFA0112200,2017YFA0103304,2017YFA0102802,2018YFA0107203,2020YFA0113400);the Program of the Beijing Natural Science Foundation(Z190019,JQ20031);the Key Research Program of the Chinese Academy of Sciences(KFZDSW-221);K.C.Wong Education Foundation(GJTD-2019-06,GJTD-2019-08);Beijing Hospitals Authority Youth Programme(QML20200802);Youth Innovation Promotion Association of CAS(E1CAZW0401,2021078);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2020-JKCS-011);the State Key Laboratory of Stem Cell and Reproductive Biology,the State Key Laboratory of Membrane Biology,the 14th Five-year Network Security and Informatization Plan of Chinese Academy of Sciences(WX145XQ07-18);the Informatization Plan of Chinese Academy of Sciences(CAS-WX2021SF-0301);the Milky Way Research Foundation(MWRF),Young Elite Scientists Sponsorship Program by CAST(NO.YESS20200012);CAS Project for Young Scientists in Basic Research(YSBR-012)and the Tencent Foundation.
Dear Editor,Chloroquine(CQ)has long been used as an anti-malarial agent(Wellems and Plowe,2001).Recently,CQ has also been applied to treat viral infection and related diseases(Wellems and Plowe,2001;Huang et al.,2020)...
关键词：protective inhibited INTESTINE 
Antibiotic Therapy and Offstage about Covid-19 Vaccination
《Health》2022年第6期675-683,共9页Mahira Amirova Lala Huseynova Sabrin Azim Svetlana Nagiyeva Muthiah Lovely Gulnara Dashdamirova Ban Almudarris Farah Saed 
In this overview, we discuss the impact of antibiotic therapy on the COVID infection, the complications after vaccination, possible causes of adverse events, and ways to protect against pandemic infection, as well as ...
关键词：CHLOROQUINE CO-INFECTION COVID-19 SARS-CoV-2 Secondary Infection MUTATION Mythbusters VACCINATION 
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