FIBROBLAST

作品数：334被引量：1055H指数：16
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相关作者：刘璇赵晓燕赵连友张兴凯熊兵更多>>
相关机构：中国科学院哈尔滨医科大学第二军医大学温州医科大学更多>>
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Dynamic development of microglia and macrophages after spinal cord injury
《Neural Regeneration Research》2025年第12期3606-3619,共14页Hu-Yao Zhou Xia Wang Yi Li Duan Wang Xuan-Zi Zhou Nong Xiao Guo-Xing Li Gang Li 
Secondary injury following spinal cord injury is primarily characterized by a complex inflammatory response,with resident microglia and infiltrating macrophages playing pivotal roles.While previous studies have groupe...
关键词：acute inflammation bioinformatics analysis FIBROBLAST integrinβ2 ligand-receptor interaction NEUROINFLAMMATION oncostatin M single-cell RNA sequencing spatial transcriptomics spinal cord injury 
Inhibitory effect of ferroptosis inhibitor toxicity induced by cobalt nanoparticles through reactive oxygen species
《中国组织工程研究》2025年第34期7310-7317,共7页Wang Chen Zhang Weinan Shen Jining Liu Fan Yuan Jishan Liu Yake 
国家自然科学基金面上项目(82172519),项目负责人:刘璠;国家自然科学基金青年科学基金项目(82002282),项目负责人:刘雅克。
BACKGROUND:Soft tissue damage induced by cobalt nanoparticles is currently the most noticeable complication in patients with artificial joint prostheses.Therefore,an effective therapeutic strategy is needed to limit t...
关键词：cobalt nanoparticle ARTHROPLASTY ferroptosis inhibitor ferroptosis reactive oxygen species DEFERIPRONE metal implant detoxify nanobiomedicine pathway FIBROBLAST 
Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids
《World Journal of Gastrointestinal Surgery》2025年第4期333-346,共14页Min-Hui Ke Shu-Yan Huang Wei-Gan Lin Zhen-Guo Xu Xia-Xia Zheng Xian-Bao Liu You-Min Cheng Zuan-Fang Li 
Supported by the National Natural Science Foundation of China,No.81774118;the Foreign Cooperation Project of Science and Technology Department of Fujian Province,No.2023I0021;the Medical Innovation Project of Fujian Province,No.2024CXB013.
BACKGROUND Hemorrhoids,a prevalent chronic condition globally,significantly impact patients'quality of life.While various surgical interventions,such as external stripping and internal ligation,procedure for prolapse ...
关键词：Internal hemorrhoids Xiaozhiling injection FIBROBLAST Marker gene Single-cell sequencing Spatial transcriptome sequencing 
Nicotinamide N-methyltransferase negatively regulates metastasis-promoting property of cancer-associated fibroblasts in lung adenocarcinoma
《Cancer Communications》2025年第2期110-137,共28页Peiyu Wang Guangxi Wang Haoran Li Yuyao Yuan Haiming Chen Shaodong Wang Zewen Sun Fanjie Meng Yun Li Fan Yang Jun Wang Kezhong Chen Mantang Qiu 
National Natural Science Foundation of China,Grant/Award Numbers:92059203,82173386;National Key R&D Program of China,Grant/Award Number:2023YFF0723500;Research Unit of Intelligence Diagnosis and Treatment in Early Non-small Cell Lung Cancer,Chinese Academy of Medical Sciences,Grant/Award Number:2021RU002;Medical and Health Science and Technology Innovation project,Grant/Award Number:2021-I2M-002;Beijing Nova Program,Grant/Award Number:20230484314;Innovation Fund for Excellent PhD student of Peking University Health Science Center,Grant/Award Number:2022-58。
Background:Recurrence and metastasis remain significant challenges in lung adenocarcinoma(LUAD)after radical resection.The mechanisms behind the recurrence and metastasis of LUAD remain elusive,and deregulated cellula...
关键词：Nicotinamide N-methyl transferase Lung cancer Cancer-associated fibroblast Extracellular matrix Metastasis 
Locally producing antibacterial peptide to deplete intratumoral pathogen for preventing metastatic breast cancer
《Acta Pharmaceutica Sinica B》2025年第2期1084-1097,共14页Shizhen Geng Tingting Xiang Yaru Shi Mengnian Cao Danyu Wang Jing Wang Xinling Li Haiwei Song Zhenzhong Zhang Jinjin Shi Junjie Liu Airong Li Ke Sun 
supported by the National Natural Science Foundation of China(82172762,21904119,and 82073395);Science and technology innovation talents support project of Henan Province(23HASTIT041);Henan Science Fund for Outstanding Young Scholars(232300421051,China).
Metastatic dissemination is the major cause of death from breast-cancer(BC).Fusobacterium nucleatum(F.n)is widely enriched in BC and has recently been identified as one of the high-risk factors for promoting BC metast...
关键词：Intratumoral pathogen METASTASIS Antibacterial peptide OPTOGENETICS Breast cancer Fusobacterium nucleatum Cancer-associated fibroblast Mild heat 
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression
《Acta Pharmaceutica Sinica B》2025年第2期876-891,共16页Yuyu Zhu Lixin Zhao Wei Yan Hongyue Ma Wanjun Zhao Jiao Qu Wei Zheng Chenyang Zhang Haojie Du Meng Yu Ning Wan Hui Ye Yicheng Xie Bowen Ke Qiang Xu Haiyan Sun Yang Sun Zijun Ouyang 
supported by the National Key Research and Development Plan(2022YFC3500202,China);the National Natural Science Foundation of China(Nos.82230116,81872877,82204715,81803142,82404639,and 82073975);the Natural Science Foundation of Jiangsu Province(No.BK20220476,China);the Jiangsu Provincial Double-Innovation Doctor Program(No.JSSCBS20220477,China);the Natural Science Foundation of Nanjing University of Chinese Medicine(No.XPT82204715,China);the Fundamental Research Funds for the Central Universities(Nos.020814380179 and 020814380174,China);the Fundamental Science(Natural Science)Research Project of the Jiangsu Higher Education Institutions of China(No.22KJB360005);the Innovation Project of Guangdong Provincial Education Department(No.2023KTSCX320,China);the Shenzhen Science and Technology Program(Nos.20231126130044001 and 20230731094501002,China);the School of Life Science(NJU)-Sipimo Joint Funds,and the Mountain-Climbing Talents Project of Nanjing.
Psoriasis is an incurable chronic inflammatory disease that requires new interventions.Here,we found that fibroblasts exacerbate psoriasis progression by promoting macrophage recruitment via CCL2 secretion by single-c...
关键词：PSORIASIS FIBROBLAST CCL2 CELASTROL LRP1 MACROPHAGE C-JUN Drug target 
Emodin promotes the recovery of rheumatoid arthritis by regulating the crosstalk between macrophage subsets and synovial fibroblast subsets被引量：1
《Animal Models and Experimental Medicine》2025年第1期44-56,共13页Lianying Cheng Xiaofeng Rong 
Background : To study the relationships among emodin, synovial fibroblasts (FLSs), and macrophages (STMs) to provide guidance for the use of emodin in rheumatoid arthritis (RA) treatment. Methods : RA clinical samples...
关键词：EMODIN fibroblast synoviocytes MACROPHAGES rheumatoid arthritis 
Hypoxia combined with radiation reverses migration and invasion of head and neck squamous cell carcinoma by remodeling extracellular vesicle-mediated transfer of miR-23b-5p from cancer-associated fibroblasts
《Malignancy Spectrum》2024年第4期275-289,共15页Chuanshi He Mingzhe Xie Zhimi Zhang Bangrong Cao Huaichao Luo Guiquan Zhu Shun Lu Ling Li 
supported by the National Natural Science Foundation of China(81972541,81872196,and 82273307);the Natural Science Foundation of Sichuan Province(2022NSFSC0681 and 2022NSFSC0632)。
Background:Cancer-associated fibroblasts(CAFs),the main matrix components in the tumor microenvironment(TME),play a crucial role in tumor progression.Extracellular vesicles(EVs)as main mediators in intercellular commu...
关键词：cancer-associated fibroblast extracellular vesicle HYPOXIA RADIOTHERAPY head and neck squamous cell carcinoma 
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
《International Journal of Oral Science》2024年第4期671-684,共14页Changqing Xie Liang Zhong Hui Feng Rifu Wang Yuxin Shi Yonglin Lv Yanjia Hu Jing Li Desheng Xiao Shuang Liu Qianming Chen Yongguang Tao 
supported by grants from the National Natural Science Foundation of China(82201079);the Natural Science Foundation of Hunan Province,China(2023JJ40881);the Major Project of Natural Science Foundation of Hunan Province(Open Competition,2021JC0002);the Fundamental Research Funds for the Central Universities of Central South University(2023ZZTS0582)。
Oral submucous fibrosis(OSF)is a chronic and inflammatory mucosal disease caused by betel quid chewing,which belongs to oral potentially malignant disorders.Abnormal fibroblast differentiation leading to disordered co...
关键词：EPITHELIUM metabolism diagnosis 
Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway
《Signal Transduction and Targeted Therapy》2024年第12期5671-5683,共13页Guichuan Huang Xiangsheng Yang Qingyang Yu Qun Luo Chunrong Ju Bangyan Zhang Yijing Chen Zihan Liang Shu Xia Xiaohua Wang Dong Xiang Nanshan Zhong Xiao Xiao Tang 
supported by the National Natural Science Foundation of China(XT,82270077 and 82470065);the National High-Level Talents Program(XT),R&D Program of Guangzhou National Laboratory,Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01S155);Open Project of State Key Laboratory of Respiratory Disease(SKLRD-OP-202320);the grant of State Key Laboratory of Respiratory Disease(SKLRD-Z-202416);Guangzhou Institute of Respiratory Health Open Project(XT),Postdoctoral Startup Fund of Guangzhou City(GH).
Fibroblast activation plays an important role in the occurrence and development of idiopathic pulmonary fibrosis(IPF),which is a progressive,incurable,and fibrotic lung disease.However,the underlying mechanism of fibr...
关键词：inhibited protective INHIBITING 
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