PSORIASIS

作品数：348被引量：619H指数：13
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相关作者：贾泰元王文明吴倩陈志强张弛更多>>
相关机构：首都医科大学安徽医科大学中国医学科学院北京协和医学院西安市中心医院更多>>
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Microneedle-Based Approaches for Skin Disease Treatment
《Nano-Micro Letters》2025年第6期143-180,共38页Yanhua Han Xiaoyu Qin Weisen Lin Chen Wang Xuanying Yin Jiaxin Wu Yang Chen Xiaojia Chen Tongkai Chen 
supported through grants from the Key Fields of Biomedicine and Health Foundation of Colleges and Universities in Guangdong Province(2022ZDZX2017);the National Natural Science Foundation of China(82104354);the Guangdong Basic and Applied Basic Research Foundation(2022A1515012154);the funding grants from University of Macao and the University of Macao Development Foundation(MYRG2023-GRG00184-ICMS-UMDF and MYRG2024-GRG00271-ICMS-UMDF).
The use of microneedles(MNs)has been established as an effective transdermal drug delivery strategy that has been extensively deployed for treating various diseases,including skin diseases.MNs can surpass the constrai...
关键词：MICRONEEDLES Androgenetic alopecia PSORIASIS Atopic dermatitis Hypertrophic scars MELANOMA 
Psoriasis,metabolic syndrome and methotrexate:Is this association suitable for a new subcategory in steatotic liver disease?
《World Journal of Hepatology》2025年第4期11-18,共8页Luciana Agoglia Maria Chiara Chindamo Cristiane Villela-Nogueira 
Psoriasis is a prevalent inflammatory disease that shares chronic inflammation pathways with the pathophysiology of metabolic syndrome(MetS),type-2 diabetes mellitus and atherosclerosis.A high prevalence of steatosis ...
关键词：PSORIASIS Genetic polymorphisms METHOTREXATE Metabolic dysfunctionassociated steatotic liver disease Liver fibrosis Transient elastography 
The Role of Childhood Stress in Inflammatory Skin Conditions: A Neuroimmune Investigation
《Modern Research in Inflammation》2025年第1期20-32,共13页Marissa Ruppe Colin Burnette Emily Deehan Emily Woolhiser Haily Fritts Kelly Frasier Aspynn Owsley Savannah K. Fakhouri Veronica Rodriguez 
Emerging evidence indicates that childhood stressors, such as familial conflict, bullying, academic pressure, and traumatic events, can significantly worsen inflammatory skin conditions like atopic dermatitis (AD) and...
关键词：Childhood Stressors Neuroimmune Pathways Cortisol Dysregulation Psychophysiological Response Stress Management Pro-Inflammatory Cytokines Atopic Dermatitis PSORIASIS 
Aggregation-Induced Emission-Active Photosensitizer-Mediated Photodynamic Therapy for Anti-Psoriasis
《Research》2025年第1期935-954,共20页Ping Zhu Zhaoji Wu Zhilu Yang Tingting Tang Yunhui Liao Wen Zhao Ying Huang Tao Chen Junjie Li Chunmei Nong Zhenzhen Wu Guodong Hu Yanshan Liu Yinghua Chen 
supported by the Natural Science Funding of Guangdong Province(2022A1515012312 and 2021A1515010023);the National Natural Science Funding of China(82070083);Dongguan Social development technology projects Science and Technology Planning Project(20231800940792).
Hyperproliferative keratinocytes and subcutaneous inflammation contribute to the characteristic symptoms of psoriasis,including erythema,scales,or scaly plaques on the skin.These symptoms significantly affect patients...
关键词：PSORIASIS PHOTOSENSITIZER hyperproliferative keratinocytes subcutaneous inflammation scaly plaques organic photosensitizer photodynamic therapy treatment strategies 
The Impact of Reproductive Traits on Psoriasis Risk is Mediated by Education Attainment and Body Mass Index: A Mendelian Randomization Study
《Biomedical and Environmental Sciences》2025年第3期365-375,共11页Yajia Li Qiangxiang Li Ziqin Cao Jianhuang Wu 
supported by the National Key R&D Program of China(No,2019YFA0112100);the National Natural Science Foundation of China(No.81472073);the Fundamental Research Funds for the Central Universities of Central South University(Grant Number:2022ZZTS0824).
Objective To explore the causality between reproductive traits and risk of psoriasis by using a large Mendelian randomization(MR)study.Methods A two-sample MR study was performed using summarized statistics from the g...
关键词：Age at first sexual intercourse Age at first birth PSORIASIS Psoriatic arthritis Psoriasis vulgaris Genetic epidemiology Mendelian randomization 
Microneedle-delivered biomimetic nanodecoys target type Ⅳ collagen and scavenge multiple cytokines to alleviate psoriatic inflammation
《Nano Research》2025年第3期401-416,共16页Fei Qu Jinying Qin Min Li Yuting Xia Yihui Wang Hongmei Liu Juan Tao Yijing Liu Jintao Zhu 
financially supported by the National Natural Science Foundation of China(No.52373138);the Fundamental Research Funds for the Central Universities(HUST:2023JYCXJJ052 and 2020kfyXJJS060);Shenzhen Science and Technology Program(No.CYJ20220530160603007).
The immunomodulatory efficacy of current psoriasis biological therapies is hindered by their limited ability to scavenge multiple cytokines,inefficient delivery to specific inflamed skin regions,and potential side eff...
关键词：nanodecoy MICRONEEDLE type IV collagen-targeting cytokines scavenging PSORIASIS 
Application of Health Action Process Approach Theory in Patients with Type D Personality Psoriasis
《Journal of Biosciences and Medicines》2025年第2期67-77,共11页Qian Sun Jing Wang Yachun Yao Xue Hu Yi Liu Jingjing Liu 
Objective: To explore the effect of Health Action Process Approach (HAPA) theory in patients with type D personality psoriasis. Methods: A total of 66 patients with type D personality psoriasis admitted to the dermato...
关键词：Health Action Process Approach Theory Type D Personality PSORIASIS SELF-EFFICACY Negative Emotions Quality of Life 
Ferroptosis-related gene biomarkers in psoriasis:diagnostic potential and insights for traditional chinese medicine treatments
《Journal of Chinese Pharmaceutical Sciences》2025年第2期150-162,共13页Xiaoyan Ma Di Wu 
Yunnan Provincial Excellent Clinical Talents Training Project(the First Batch)(Yunnan Financial Society(2024)No.103).
This research aimed to identify and validate ferroptosis-related signature genes associated with psoriasis through a comprehensive bioinformatics approach,while also predicting potential traditional Chinese medicines(...
关键词：PSORIASIS Ferroptosis Fer-DEGs Traditional Chinese medicine prediction 
Celastrol directly targets LRP1 to inhibit fibroblast-macrophage crosstalk and ameliorates psoriasis progression
《Acta Pharmaceutica Sinica B》2025年第2期876-891,共16页Yuyu Zhu Lixin Zhao Wei Yan Hongyue Ma Wanjun Zhao Jiao Qu Wei Zheng Chenyang Zhang Haojie Du Meng Yu Ning Wan Hui Ye Yicheng Xie Bowen Ke Qiang Xu Haiyan Sun Yang Sun Zijun Ouyang 
supported by the National Key Research and Development Plan(2022YFC3500202,China);the National Natural Science Foundation of China(Nos.82230116,81872877,82204715,81803142,82404639,and 82073975);the Natural Science Foundation of Jiangsu Province(No.BK20220476,China);the Jiangsu Provincial Double-Innovation Doctor Program(No.JSSCBS20220477,China);the Natural Science Foundation of Nanjing University of Chinese Medicine(No.XPT82204715,China);the Fundamental Research Funds for the Central Universities(Nos.020814380179 and 020814380174,China);the Fundamental Science(Natural Science)Research Project of the Jiangsu Higher Education Institutions of China(No.22KJB360005);the Innovation Project of Guangdong Provincial Education Department(No.2023KTSCX320,China);the Shenzhen Science and Technology Program(Nos.20231126130044001 and 20230731094501002,China);the School of Life Science(NJU)-Sipimo Joint Funds,and the Mountain-Climbing Talents Project of Nanjing.
Psoriasis is an incurable chronic inflammatory disease that requires new interventions.Here,we found that fibroblasts exacerbate psoriasis progression by promoting macrophage recruitment via CCL2 secretion by single-c...
关键词：PSORIASIS FIBROBLAST CCL2 CELASTROL LRP1 MACROPHAGE C-JUN Drug target 
Topical adhesive spatio-temporal nanosystem co-delivering chlorin e6 and HMGB1 inhibitor glycyrrhizic acid for in situ psoriasis chemo-phototherapy
《Acta Pharmaceutica Sinica B》2025年第2期1126-1142,共17页Lijun Su Yixi Zhu Xuebo Li Di Wang Xiangyu Chen Zhen Liu Jingjing Li Chen Zhang Jinming Zhang 
supported by funding from the China Postdoctoral Science Foundation(Nos.2023T160071 and 2021M690488);Natural Science Foundation of Sichuan Province of China for Youths(No.2023NSFSC1768,China);The Science and Technology Development Fund(SKL-QRCM(UM)2023-2025,China);The State Key Laboratory of Quality Research in Chinese Medicine,University of Macao(No.SKL-QRCM-OP23020,China);The Central Guidance on Local Science and Technology Development Fund of Sichuan(23ZYZYTS0420,China);Multidisciplinary Evaluation of Southwest Characteristic TCM Resources Multidisciplinary Interdisciplinary Innovation Team(No.ZYYCXTD-D-202209,China).
Recently,photodynamic therapy(PDT)has gained considerable attention as a promising therapeutic approach for the treatment of psoriasis.Unfortunately,the activation of high mobility group box 1 protein(HMGB1)by PDT tri...
关键词：PSORIASIS Chitosan CATECHOL Spatio-temporal nanosystem Glycyrrhizic acid liposome Chemo-phototherapy Topical delivery ANTI-INFLAMMATION 
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