MICRONEEDLE

作品数：110被引量：304H指数：10
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相关作者：王宁更多>>
相关机构：安徽医科大学合肥工业大学上海交通大学清华大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金中国博士后科学基金北京市自然科学基金更多>>
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Microneedle-Based Approaches for Skin Disease Treatment
《Nano-Micro Letters》2025年第6期143-180,共38页Yanhua Han Xiaoyu Qin Weisen Lin Chen Wang Xuanying Yin Jiaxin Wu Yang Chen Xiaojia Chen Tongkai Chen 
supported through grants from the Key Fields of Biomedicine and Health Foundation of Colleges and Universities in Guangdong Province(2022ZDZX2017);the National Natural Science Foundation of China(82104354);the Guangdong Basic and Applied Basic Research Foundation(2022A1515012154);the funding grants from University of Macao and the University of Macao Development Foundation(MYRG2023-GRG00184-ICMS-UMDF and MYRG2024-GRG00271-ICMS-UMDF).
The use of microneedles(MNs)has been established as an effective transdermal drug delivery strategy that has been extensively deployed for treating various diseases,including skin diseases.MNs can surpass the constrai...
关键词：MICRONEEDLES Androgenetic alopecia PSORIASIS Atopic dermatitis Hypertrophic scars MELANOMA 
Microneedle-delivered biomimetic nanodecoys target type Ⅳ collagen and scavenge multiple cytokines to alleviate psoriatic inflammation
《Nano Research》2025年第3期401-416,共16页Fei Qu Jinying Qin Min Li Yuting Xia Yihui Wang Hongmei Liu Juan Tao Yijing Liu Jintao Zhu 
financially supported by the National Natural Science Foundation of China(No.52373138);the Fundamental Research Funds for the Central Universities(HUST:2023JYCXJJ052 and 2020kfyXJJS060);Shenzhen Science and Technology Program(No.CYJ20220530160603007).
The immunomodulatory efficacy of current psoriasis biological therapies is hindered by their limited ability to scavenge multiple cytokines,inefficient delivery to specific inflamed skin regions,and potential side eff...
关键词：nanodecoy MICRONEEDLE type IV collagen-targeting cytokines scavenging PSORIASIS 
Microneedle technology in analgesic therapy
《Nano Research》2025年第2期488-502,共15页Jie Jiao Ze Qiang Zhao Yu Ting He Bin Bin Yu Kejun Chen Youchen Xia Ruixing Yu Bo Zhi Chen Xin Dong Guo 
This work was financially supported by the National Natural Science Foundation of China(Nos.52161145410,52373126,and 52303173);Beijing University of Chemical Technology-China Japan Friendship Hospital Biomedical Translational Engineering Research Center Key Projects(No.XK2023-20);Grant from State Key Laboratory of Organic-Inorganic Composites(No.oic 202401005);the Fundamental Research funds for the Central Universities(No.ZY2453);the long-term subsidy mechanism from the Ministry of Finance and the Ministry of Education of PRC.
Pain management has become a prominent global health concern,affecting not only over the aspects of daily existence but also upon the holistic physical well-being.Conventional pain management methods have non-negligib...
关键词：MICRONEEDLE pain management clinical analgesic trials LIDOCAINE 
Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases
《Nano-Micro Letters》2024年第12期233-284,共52页Qingdong Bao Xiaoting Zhang Zhankun Hao Qinghua Li Fan Wu Kaiyuan Wang Yang Li Wenlong Li Hua Gao 
supported by the National Natural Science Foundation of China(82371032,82070923);the Major Basic Research Project of the Natural Science Foundation of Shandong Province(ZR2023ZD60);the Taishan Scholar Program(20231255);the Academic Promotion Program of Shandong First Medical University(2019RC009).
The eye,a complex organ isolated from the systemic circulation,presents significant drug delivery challenges owing to its protective mechanisms,such as the blood-retinal barrier and corneal impermeability.Conventional...
关键词：Ocular delivery POLYSACCHARIDE MICRONEEDLES Drug administration 
Miniaturized all-in-one microneedle device for point of care light therapy被引量：1
《npj Flexible Electronics》2024年第1期591-601,共11页Huiting Zhao Xu Wang Jiyuan Xiong Guomin Liang Xin Wu Jiyu Xi Yu Zhang Zixi Li Xiaoming Hu Zewen Wei 
supported by the National High Technology Research and Development Program of China(No.2022YFC2403301);the National Natural Science Foundation of China(No.62074016);the Frontier Interdisciplinary Innovation Project of Beijing Institute of Technology(2023CX11011);the Laboratory Funding of the National Key Laboratory of Science and Technology on Micro/Nano Fabrication(No.6142805200104);the Quancheng-5150 Talent Supporting Project of Jinan(Laureate,Zewen Wei)and the Industrial Talent Supporting Project of Huaiying(Laureate,Zewen Wei).
Light therapies have been applied to millions of patients for treating many kinds of diseases,especially superficial ones.Currently,mainstream light therapies utilize the combined effects of photosensitizers and light...
关键词：NEEDLE SUPERFICIAL PATCH 
Dissolvable microneedle-based wound dressing transdermally and continuously delivers anti-inflammatory and pro-angiogenic exosomes for diabetic wound treatment
《Bioactive Materials》2024年第12期32-51,共20页Yanpeng Cao Bei Chen Qixing Liu Yiyang Mao Yusheng He Xiaoren Liu Xin Zhao Yaowu Chen Xiying Li Yabei Li Liang Liu Chengwu Guo Shiyu Liu Fenghua Tan Hongbin Lu Jun Liu Can Chen 
financially supported through grants from the National Natural Science Foundation of China(Grant No.82272497);Hunan Provincial Natural Science Foundation(Grant Nos.2021JJ20093,2022JJ30001,2023JJ40090);the Hunan Provincial Health Commission Scientific Research Projects(Grant No.202204075237).
Due to overactive inflammation and hindered angiogenesis,self-healing of diabetic wounds(DW)remains challenging in the clinic.Platelet-derived exosomes(PLT-Exos),a novel exosome capable of anti-inflammation and pro-an...
关键词：Acellular dermal matrix Diabetic wound EXOSOMES MICRONEEDLE Transdermal delivery 
Application of microneedle arrays in cosmetics: Promises, advances, and challenges
《Medicine in Novel Technology and Devices》2024年第4期1-19,共19页Amarjitsing Rajput Anuradha Patil Priyanka Kandhare Atmaram Pawar 
Microneedle technology involves skin puncturing and has emerged as an innovative approach for drug delivery and cosmetic applications.MNs offer advantages over traditional injections,such as reduced pain,infection ris...
关键词：MICRONEEDLE COSMETICS BIOCOMPATIBILITY Regulatory aspects Clinical applications 
Controllable Histotomy Based on Hierarchical Magnetic Microneedle Array Robots
《Engineering》2024年第11期166-174,共9页Xiaoxuan Zhang Hanxu Chen Taiyu Song Jinglin Wang Yuanjin Zhao 
supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(T2225003,52073060,61927805);the Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);the Guangdong Basic and Applied Basic Research Foundation(2021B1515120054).
Investigation of patient-derived primary tissues is of great importance in the biomedical field,but recent tissue slicing and cultivation techniques still have difficulties in satisfying clinical requirements.Here,we ...
关键词：Histotomy Drug screening MICRONEEDLE MICROROBOT Tumor-on-a-chip High throughput 
Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing
《Acta Pharmaceutica Sinica B》2024年第11期5037-5052,共16页Yongnian Zeng Chenyuan Wang Jiapeng Lei Xue Jiang Kai Lei Yinli Jin Tianshu Hao Wen Zhang Jianying Huang Wei Li 
National Natural Science Foundation of China(NSFC,Nos.82373798,52103182);the Special Project for Significant New Drug Research and Development in the Major National Science and Technology Projects of China(project No.2020ZX09201007);Innovation Transformation Research Project of Zhongnan Hospital of Wuhan University(project No.YXCXZH2024003,China).
High glucose level, bacterial infection, and persistent inflammation within the microenvironment are key factors contributing to the delay of diabetic ulcers healing, while traditional therapeutic methods generally fa...
关键词：MICRONEEDLE Wound healing DRUGDELIVERY Sustained release Nitric oxide Glucosedepletion Glucose oxidase Nanoparticles 
The microneedle bandages provide new hope for healing diabetic wounds
《Acta Pharmaceutica Sinica B》2024年第11期5085-5087,共3页Saadullah Khattak Hong-Tao Xu Jianliang Shen 
Biofilm infections, chronic inflammation, and delayed new blood vessel generation all prolong the treatment proceeding of diabetic wounds. Several treatment methods exist for the healing of diabetic wounds, incorporat...
关键词：Microneedle bandage Biofilms Antibacterial Photodynamic therapy Diabetic wound healing 
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