DRUGDELIVERY

作品数：7被引量：6H指数：2
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Strategies for intravesical drug delivery:From bladder physiological barriers and potential transport mechanisms
《Acta Pharmaceutica Sinica B》2024年第11期4738-4755,共18页Zheng-an Li Kai-chao Wen Ji-heng Liu Chuan Zhang Feng Zhang Feng-qian Li 
Shanghai Xuhui medical research project(SHXH202110 and SHXH202230,China);Natural Science Foundation of Shanghai(21ZR1447900,China);Key Discipline Construction Project(SHXHZDXK202310,China)of Shanghai Xuhui Health System.
Intravesical drug delivery(IDD),as a noninvasive,local pathway of administration,has great clinical significance for bladder diseases,especially bladder cancer.Despite the many advantages of IDD such as enhanced focal...
关键词：Intravesical drugdelivery Bladdercancer Transport barrier Carrierdesign Deliverymechanism PENETRATION Intravesical therapy BLADDER 
Spatiotemporally responsive cascade bilayer microneedles integrating local glucose depletion and sustained nitric oxide release for accelerated diabetic wound healing
《Acta Pharmaceutica Sinica B》2024年第11期5037-5052,共16页Yongnian Zeng Chenyuan Wang Jiapeng Lei Xue Jiang Kai Lei Yinli Jin Tianshu Hao Wen Zhang Jianying Huang Wei Li 
National Natural Science Foundation of China(NSFC,Nos.82373798,52103182);the Special Project for Significant New Drug Research and Development in the Major National Science and Technology Projects of China(project No.2020ZX09201007);Innovation Transformation Research Project of Zhongnan Hospital of Wuhan University(project No.YXCXZH2024003,China).
High glucose level, bacterial infection, and persistent inflammation within the microenvironment are key factors contributing to the delay of diabetic ulcers healing, while traditional therapeutic methods generally fa...
关键词：MICRONEEDLE Wound healing DRUGDELIVERY Sustained release Nitric oxide Glucosedepletion Glucose oxidase Nanoparticles 
Purpurolide C-based microneedle promotes macrophage-mediated diabetic wound healing via inhibiting TLR4-MD2 dimerization and MYD88 phosphorylation被引量：3
《Acta Pharmaceutica Sinica B》2023年第12期5060-5073,共14页Yitong Liu Guiyang Xia Yingyi Chen Huan Xia Junji Xu Lijia Guo Sheng Lin Yi Liu 
supported by grants from National Key R&D Program of China(Grant NO.2022YFC2504200 to Yi Liu);the National Nature Science Foundation of China(81991504 and 81974149 to Yi Liu,82073978 to Sheng Lin,82201053 to Yitong Liu,81803397 to Guiyang Xia,82122015 to Junji Xu);the Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University(CXTD202202 to Yi Liu,China);the Innovation Foundation of Beijing Stomatological Hospital,Capital Medical University(21-09-18 to Lijia Guo,China);the Beijing Stomatological Hospital,Capital Medical University Young Scientist Program(YSP202105 to Yitong Liu,China);the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(ZYLX202121 to Yi Liu,China);Beijing Municipal Administration of Hospitals'Ascent Plan(DFL20181501 to Yi Liu,China);Beijing Municipal Administration of Hospitals'Youth Programme(QML20181501 to Lijia Guo,QML20231506 to Yitong Liu,China);Beijing Municipal Administration of Hospitals Incubating Program(PX2023054 to Lijia Guo,China).
Delayed wound healing in diabetes is a global challenge,and the development of related drugs is a clinical problem to be solved.In this study,purpurolide C(PC),a small-molecule secondary metabolite of the endophytic f...
关键词：Diabetes Wound healing Purpurolide C Liposome and GelMA-based microneedle patches Macrophage polarization Inflammation DRUGDELIVERY Molecular mechanism 
Imaging-Guided Cancer Therapy Based on Multifunctional Magnetic Nanoparticles
《Chinese Journal of Chemistry》2023年第19期2557-2573,共17页Ran Ma Yanglong Hou Shuren Wang 
support from the National Natural Science Foundation of China(52201198,52027801,and 51631001);the National Key R&D Program of China(2017YFA0206301);the China-Germany Collaboration Project(M-0199).
In recent years,magnetic nanoparticles(MNPs)have received great attention within the field of biomedicine,especially for cancer therapy.This is because MNPs have many excellent physical and chemical properties to prov...
关键词：CANCER Cancer therapy Modal imaging Magnetic nanoparticles Synergistic action NANOTECHNOLOGY Synthesis design DRUGDELIVERY Imagingagents 
Construction of Nanocarriers Based on Endogenous Cell Membrane and Their Application in Nanomedicine被引量：1
《Chinese Journal of Chemistry》2022年第13期1623-1640,共18页Yingshu Guo Wenxin Li Shiwei Liu Dan Jing Yifan Wang Qingfang Feng Kaixiang Zhang Jing-Juan Xu 
This work was supported by the Development Plan of Youth Innovation Team in Colleges and Universities of Shandong Province(2020KJC003).
Inspired by the adaptation of cells to the surrounding environment,the combination of cell membrane and nanomaterials has gradually become a new type of biomimetic nanocomposite.The construction of endogenous membrane...
关键词：Biomimeticnanocomposite Membranes NANOMEDICINE Antitumoragents DRUGDELIVERY 
Can the venerated silk be the next generation nanobiomaterialfor biomedical device designing, regenerative medicine and drugdelivery? Prospects and hitches被引量：2
《Bio-Design and Manufacturing》2019年第4期278-286,共9页Rocktotpal Konwarh 
Of late, the relevance of silk in a myriad of material science and biotechnological realms has been realized, as attested by the incessantly clambering number of reports and patents in the scienti fic repositories. Th...
关键词：Drug delivery MICROFLUIDICS Nanobiomaterial Regenerative medicine SILK Tissue engineering 
Development of new ionic gelation strategy： Towards the preparation of new monodisperse and stable hyaluronic acid/ β-cyclodextrin-grafted chitosan nanoparticles as drug delivery carriers for doxorubicin
《Frontiers of Materials Science》2018年第1期83-94,共12页Amina Ben MIHOUB Boubakeur SAIDAT Youssef BAL Celine FROCHOT Regis VANDERESSE Samir ACHERAR 
In the present study, β-cyclodextrin-grafted chitosan nanoparticles （β-CD- g-CS NPs） were prepared using a new ionic gelation strategy involving a synergistic effect of NaCI （150 mmol/L）, 4-（2-hydroxyethyl）-1-...
关键词：β-cyclodextrin-grafted chitosan hyaluronic acid ionic gelation DRUGDELIVERY physicochemical parameters control 
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