CANCER

作品数：4075被引量：18669H指数：44
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相关机构：复旦大学中山大学军事医学科学院中国科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma
《Genes & Diseases》2025年第2期64-67,共4页Yue Weng Xiangyu Yan Biying Chen Zhouliang Bian Yunhui Ge Hong Lu Shufang He Jian Wu Yong Chen Ming Lei Yanjie Zhang 
supported by grants from the National Natural Science Foundation of China (No.31930063 to Ming Lei,82072638 to Yanjie Zhang,32100582 to Yunhui Ge);Innovative Research Team of High-level Local University in Shanghai,China (No.SHSMU-ZLCX20211700 to Ming Lei);Shanghai Municipal Health Commission and Collaborative Innovation Cluster Project (China) (No.2019CXJQ01 to Ming Lei).
Telomerase plays an essential role in the immortalization and stemness of cancer cells.PIN2/TRF1-interacting telomerase inhibitor 1(PinX1)functions as a telomerase inhibitor and tumor suppressor.1 However,the underlyi...
关键词：PinX1 CERVICAL CANCER 
Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration
《Genes & Diseases》2025年第2期121-124,共4页Zhangxiang Zhao Yuquan Wang Zixin Jin Huiming Han Bo Chen Mingyue Liu Kaidong Liu Shuping Zhuang Haihai Liang Yunyan Gu 
supported by the National Key Research and Development Program of China (No.2023YFF1204600);the Guangdong Province Basic and Applied Basic Research Fund (China) (No.2022A1515110765);the National Natural Science Foundation of China (No.32270710);the Outstanding Youth Foundation of Heilongjiang Province of China (No.YQ2021H005).
Breast cancer,recognized as a foremost cause of mortality among women,is characterized by a complex immune microenvironment.Alternative splicing(AS)is a crucial process leading to diverse transcript variants.Studies h...
关键词：CANCER MORTALITY IMMUNE 
Integration of rehabilitation and palliative care in cancer management:A futuristic model
《World Journal of Clinical Cases》2025年第12期14-21,共8页Raktim Swarnakar Shiv Lal Yadav 
It explores the integration of rehabilitation and palliative care in cancer management,advocating for a holistic approach that addresses the diverse needs of patients throughout their treatment journey.Traditional can...
关键词：Cancer rehabilitation Palliative care REHABILITATION Palliative medicine Physical medicine and rehabilitation 
Novel oral compound Z526 mitigates cancer-associated cachexia via intervening NF-κB signaling and oxidative stress
《Genes & Diseases》2025年第2期319-336,共18页Xiaofan Gu Shanshan Lu Shuang Xu Yiwei Li Meng Fan Guangyu Lin Yiyuan Liu Yun Zhao Weili Zhao Xuan Liu Xiaochun Dong Xiongwen Zhang 
supported by the National Natural Science Foundation of China (No.82373317,82374085,82303818,22377087);the Science and Technology Commission of Shanghai Municipality,China (No.20S11902200,16DZ2280100);the Natural Science Foundation of Shanghai Municipality,China (No.23ZR1460500);the China Postdoctoral Science Foundation (No.2023M731106)。
Cancer-associated cachexia(CAC)is a severe metabolic disorder syndrome mainly characterized by muscle and fat loss,which accounts for one-third of cancer-related deaths.No effective therapeutic approach that could ful...
关键词：Cancer-associated cachexia Fat lipolysis Muscle atrophy NF-κB signaling Oxidative stress Z526 
Evaluating pregabalin in cancer patients with chronic neuropathic pain and depression:an observational case series
《World Journal of Clinical Oncology》2025年第4期176-185,共10页Pinaki Chakraborty Mrinal Borgohain 
BACKGROUND Chronic neuropathic pain and depression are common and debilitating conditions in cancer patients,significantly impacting their quality of life.Pregabalin,an anticonvulsant medication,is used for neuropathi...
关键词：PREGABALIN CANCER Neuropathic pain DEPRESSION 
Retrospective analysis of preoperative tumor marker levels in rectal cancer patients: Implications for diagnosis
《World Journal of Gastrointestinal Surgery》2025年第3期221-228,共8页Ming Li Da-Hao Yuan Zhi Yang Teng-Xiang Lu Lei Zhang 
BACKGROUND Early detection of rectal cancer poses significant challenges.Current diagnostic methods,including colonoscopy,imaging techniques,and fecal tests,have limitations such as invasiveness,cost,and varying sensi...
关键词：Rectal cancer Tumor markers Carcinoembryonic antigen Cancer antigen 19-9 Cancer antigen 72-4 Fecal occult blood test DIAGNOSIS 
Residual gastric cancer with a mixed small cell neuroendocrine and keratinizing squamous cell carcinoma:A case report
《World Journal of Clinical Oncology》2025年第3期162-170,共9页Tian Wang Yang Cheng Fan Hu Qiang Wang 
BACKGROUND Despite advancements in early detection and treatment,the prognosis and his-tological types for residual gastric cancer(GC)remains poor.CASE SUMMARY This case report presents a rare occurrence of residual G...
关键词：Gastric stumper cancer Small cell neuroendocrine carcinoma Squamous cell carcinoma Adjuvant chemotherapy Case report 
Attention to cancer-related physical and mental fatigue:Breaking the vicious cycle
《World Journal of Psychiatry》2025年第3期1-7,共7页Yan Zeng Jun-Wen Zhang Jian Yang 
Supported by Education and Teaching Reform Project of the First Clinical College of Chongqing Medical University,No.CMER202305;Natural Science Foundation of Tibet Autonomous Region,No.XZ2024ZR-ZY100(Z);the Program for Youth Innovation in Future Medicine,Chongqing Medical University,China,No.W0138.
Cancer-related fatigue(CRF)presents as a complex interplay between physical and mental fatigue,with mindfulness interventions offering a promising approach to alleviate both.These techniques,including mindfulness-base...
关键词：Cancer-related fatigue Physical fatigue Mental fatigue MINDFULNESS Mindfulness interventions Cancer management 
Connection between heart rate variability alterations and cancer in tumor patients
《World Journal of Cardiology》2025年第3期67-72,共6页Yu-Zhu Deng Bing Song 
the Medical Ethics Committee of the Hefei Cancer Hospital,Chinese Academy of Sciences(No.PJ-KY-2024-025).
BACKGROUND A significant proportion of cancer patients experience autonomic dysfunction,and cancer treatments such as chemotherapy and radiation therapy can exacerbate impairments in the cardiac autonomic nervous syst...
关键词：Cancer patients Heart rate variability Domain and frequency domain methods Autonomic dysfunction Dynamic electrocardiogram 
Modifying metabolic and immune hallmarks of cancer by a copper complex
《Science China Chemistry》2025年第3期1051-1066,共16页Chengyan Chu Yunhua Zhang Chengyuan Qian Xiu-Zhi Yang Yicun Shang Zijian Guo Xiaoyong Wang 
the National Natural Science Foundation of China (22377053,92153303,22293051);the Natural Science Foundation of Jiangsu Province (BK20202004)。
Metabolic adaptation of cancer cells is a key tactic for maintaining their tumorigenicity and viability in the tumor immune microenvironment(TIME).Concurrent modulation on the metabolic pathway and immune system could...
关键词：cancer hallmark copper complex cuproptosis lactate metabolism IMMUNOMODULATION 
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