CANCER

作品数：4111被引量：18840H指数：45
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相关领域：医药卫生更多>>
相关作者：陈暨耀李世荣支修益刘伟寇博更多>>
相关机构：复旦大学中山大学军事医学科学院中国科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Mitochondrial quality control in human health and disease
《Military Medical Research》2025年第3期393-458,共66页Bo‑Hao Liu Chen‑Zhen Xu Yi Liu Zi‑Long Lu Ting‑Lv Fu Guo‑Rui Li Yu Deng Guo‑Qing Luo Song Ding Ning Li Qing Geng 
supported by the National Natural Science Foundation of China(8210082163,81800343);the Fundamental Research Fund for the Central Universities(2042021kf0081);the Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(2020CFA027);the Doctor of Excellence Program of the First Hospital of Jilin University(JDYY-DEP-2023043).
Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital...
关键词：Mitochondrial quality control(MQC) METABOLISM Programmed cell death CANCER Cardiovascular disease Metabolic disease Nervous disease Pulmonary disease Kidney disease Digestive system disease 
The crosstalk between non-coding RNAs and oxidative stress in cancer progression
《Genes & Diseases》2025年第3期146-167,共22页Qiqi Sun Xiaoyong Lei Xiaoyan Yang 
funded by the Hengyang City Science and Technology Planning Project(Hunan,China)(No.202150063473);the Scientific Research Project of Hunan Provincial Health Commission(China)(No.202202044140);the Scientific Research Project of Hunan Provincial Education Department(China)(No.21B0438).
As living standards elevate,cancers are appearing in growing numbers among younger individuals globally and these risks escalate with advancing years.One of the reasons is that instability in the cancer genome reduces...
关键词：ANGIOGENESIS Autophagy CANCER Cancer energy metabolism Epithelial mesenchymal transformation Non-coding RNAs Oxidative stress 
Treating human cancer by targeting EZH2
《Genes & Diseases》2025年第3期205-218,共14页Mengfei Xu Chunyan Xu Rui Wang Qing Tang Qichun Zhou Wanyin Wu Xinliang Wan Handan Mo Jun Pan Sumei Wang 
supported by grants from the Research Fund for Bajian Talents of Guangdong Provincial Hospital of Chinese Medicine(China)(No.BJ2022KY13);the National Natural Science Foundation of China(No.82274602);the Foundation for Basic and Applied Research of Guangdong Province,China(No.2021A1515220023,2017B030314166);the Chinese Medicine Science and Technology Research Project of Guangdong Provincial Hospital of Chinese Medicine(China)(No.YN2019QJ06);the Guangzhou Science and Technology Plan Project(Guangdong,China)(No.2024A03J0548,202201020349);the Key Project of State Key Laboratory of Dampness Syndrome of Chinese Medicine Jointly Built by Province and Ministry(China)(No.SZ2021ZZ38);Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases(China)(No.YN2023MB09);the Guangdong Traditional Chinese Medicine Project(China)(No.20231094,20241135).
Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator that primarily inhibitsdownstream gene expression by tri-methylating histone H3, which is usually overexpressed intumors and participates in many processes s...
关键词：CANCER Epigenetic modification EZH2 EZH2 inhibitor H3K27me3 
参白扶正颗粒治疗化疗后癌因性疲乏的临床疗效研究
《中国科技期刊数据库 医药》2025年第4期135-139,共5页郝光远 陈燕 庞军 
四川省泸州市科技局重点研发项目(2022-SYF-86)。
评价参白扶正颗粒(Shenbai Fuzheng Granules,SFG)治疗化疗后癌因性疲乏(Cancer-Related Fatigue,CRF)的临床疗效及免疫调节作用。方法 采用随机双盲对照试验设计,选取在2023年1月至2024年6月期间,于西南医科大学附属中医医院接纳的120...
关键词：癌因性疲乏(Cancer-Related Fatigue) 参白扶正颗粒 中医药 免疫功能 
Importance of hematological and inflammatory markers in the localization of gastric cancer
《World Journal of Gastrointestinal Oncology》2025年第4期93-103,共11页Suleyman Dolu Mehmet B Cengiz Huseyin Dongelli Mustafa Gurbuz Mehmet E Arayici 
This study was approved by the Agrı Training and Research Hospital Scientific Research Ethics Committee(No.E-95531838-050.99-86900);conducted in accordance with the Declaration of Helsinki.
BACKGROUND Gastric cancer is a major global health concern,often diagnosed at advanced stages,leading to poor prognosis.Proximal and distal gastric cancers exhibit distinct clinicopathological features.AIM To investig...
关键词：Gastric cancer Cancer localization Inflammatory markers Distal gastric cancer Proximal gastric cancer Hematological markers 
Curative endoscopic submucosal dissection for esophageal squamous cell carcinoma after chemoradiotherapy for pharyngeal cancer: A case report
《World Journal of Gastrointestinal Oncology》2025年第4期486-494,共9页Shion Tachibana Kentaro Moriichi Keitaro Takahashi Masahiro Sato Yu Kobayashi Yuya Sugiyama Takahiro Sasaki Aki Sakatani Katsuyoshi Ando Nobuhiro Ueno Shin Kashima Hiroki Tanabe Mikihiro Fujiya 
BACKGROUND Esophageal squamous cell carcinoma(ESCC)is often managed with surgery,which is the first-line treatment option for stage I–III lesions.However,definitive chemoradiotherapy(dCRT)is associated with a recurre...
关键词：Esophageal squamous cell carcinoma Salvage therapy Pharyngeal cancer Otolaryngological cancer CHEMORADIOTHERAPY Case report 
PinX1 suppresses cancer progression by inhibiting telomerase activity in cervical squamous cell carcinoma and endocervical adenocarcinoma
《Genes & Diseases》2025年第2期64-67,共4页Yue Weng Xiangyu Yan Biying Chen Zhouliang Bian Yunhui Ge Hong Lu Shufang He Jian Wu Yong Chen Ming Lei Yanjie Zhang 
supported by grants from the National Natural Science Foundation of China (No.31930063 to Ming Lei,82072638 to Yanjie Zhang,32100582 to Yunhui Ge);Innovative Research Team of High-level Local University in Shanghai,China (No.SHSMU-ZLCX20211700 to Ming Lei);Shanghai Municipal Health Commission and Collaborative Innovation Cluster Project (China) (No.2019CXJQ01 to Ming Lei).
Telomerase plays an essential role in the immortalization and stemness of cancer cells.PIN2/TRF1-interacting telomerase inhibitor 1(PinX1)functions as a telomerase inhibitor and tumor suppressor.1 However,the underlyi...
关键词：PinX1 CERVICAL CANCER 
Structurally diverse sesquiterpenoids with anti-MDR cancer activity from Penicillium roqueforti
《Chinese Journal of Natural Medicines》2025年第4期504-512,共9页Shuyuan Mo Nanjin Ding Zhihong Huang Jun Yao Weiguang Sun Jianping Wang Yonghui Zhang Zhengxi Hu 
supported by the National Natural Science Foundation of China(Nos.82273811,32470417,and U22A20380);the National Program for Support of Top-notch Young Professionals(No.0106514050);the Hubei Provincial Natural Science Foundationof China(No.2024AFA028);the National Key R&D Program of China(No.2021YFA0910500);the Science and Technology Major Project of Hubei Province(Nos.2021ACA012 and 2024BCB021);the Chinese Medicine Research Foundation of the Health Commission of Hubei Province(No.ZY2025Z013)。
Five novel nor-eremophilane-type sesquiterpenoids,peniroqueforins E–H and J(1–4 and 7),two new eremophilane-type sesquiterpenoids,peniroqueforins I and K(5 and 8),and a new eudesmane-type sesquiterpenoid,peniroquefo...
关键词：Penicillium roqueforti SESQUITERPENOIDS Nor-sesquiterpenoids Anti-MDR cancer activity 
Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration
《Genes & Diseases》2025年第2期121-124,共4页Zhangxiang Zhao Yuquan Wang Zixin Jin Huiming Han Bo Chen Mingyue Liu Kaidong Liu Shuping Zhuang Haihai Liang Yunyan Gu 
supported by the National Key Research and Development Program of China (No.2023YFF1204600);the Guangdong Province Basic and Applied Basic Research Fund (China) (No.2022A1515110765);the National Natural Science Foundation of China (No.32270710);the Outstanding Youth Foundation of Heilongjiang Province of China (No.YQ2021H005).
Breast cancer,recognized as a foremost cause of mortality among women,is characterized by a complex immune microenvironment.Alternative splicing(AS)is a crucial process leading to diverse transcript variants.Studies h...
关键词：CANCER MORTALITY IMMUNE 
Observation on the Clinical Effect of Traditional Chinese Medicine Fuzheng Quxie Tea Drinking Package in Treating Cancer of Zhengxu Xielian Type
《Journal of Clinical and Nursing Research》2025年第4期1-8,共8页Yongfu Dai Ke Ma Shaojun Li Qingyin Fan Yuan’e Wang Fan Yang 
Dai Yongfu’s Observation on the Clinical Effect of Traditional Chinese Medicine Fuzheng Quxie Tea Drinking Package in Treating Cancer of Zhengxu Xielian Type-A Key Scientific Research Project of the Ningxia Health and Family Planning Commission(Project No.:2019-NW-004).
Objective:To explore the clinical efficacy of traditional Chinese medicine Fuzheng Quxie tea drinking package in the treatment of Zhengxu Xielian type cancer.Methods:In this study,50 cases of Zhengxu Xielian type canc...
关键词：Traditional Chinese medicine Fuzheng Quxie tea drinking package Zhengxu Xielian type cancer Quality of life Tumor markers 
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