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IMMUNE: 作品数：1626被引量：4146H指数：24; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：邵媛媛邵宗鸿付蓉王志明陈燕更多>>; 相关机构：中山大学天津医科大学总医院山东大学中国海洋大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Polysialic acid-Siglec immune checkpoints of microglia and macrophages:Perspectives for therapeutic intervention: 《Neural Regeneration Research》2026年第2期661-662,共2页Hauke Thiesler Herbert Hildebrandt; Deutsche Forschungsgemeinschaft(DFG,German Research Foundation),project numbers 324633948 and 409784463(DFG grants Hi 678/9-3 and Hi 678/10-2,FOR2953)to HH;Bundesministerium für Bildung und Forschung-BMBF,project number 16LW0463K to HT.; Microglia are the resident macrophages of the central nervous system.They act as the first line of defense against pathogens and play essential roles in neuroinflammation and tissue repair after brain insult or in neu...; 关键词：therapeutic intervention central nervous system immune checkpoints neurodegenerative demyelinating diseases borst MACROPHAGES polysialic acid SIGLEC MICROGLIA

Prognostic significance and multidimensional roles of interferon regulatory factors in cancer biology:A comprehensive analysis: 《Genes & Diseases》2025年第3期15-18,共4页Guo Ji Shuyuan Xian Jiaqi Song Shiyu Mao Man Pi Qiongyi Huang Xue Han Jian Yin Zan Wu Runzhi Huang Dongyan Han Zhengyan Chang; supported in part by the National Natural Science Foundation of China(No.82002923,82203505).; Interferon regulatory factors(IRFs)are transcription factors with a conserved N-terminal helix-loop-helix DNA-binding domain 1.IRF family plays a pivotal role in regulating interferon transcription,immune cell develop...; 关键词：interferon regulatory factors irfs interferon regulatory factors multidimensional correlation analysiswe multidimensional roles STEMNESS transcription factors immune subtype cancer biology

Construction of a prognostic model based on the cuproptosis-related genes in pancreatic cancer: 《Genes & Diseases》2025年第3期19-22,共4页Kaili Liao Yuxin Fu Shuman Guo Tingyi Qian Feifei Teng Yuhan Xu Bing Sun Hanqing Zhao Jingyan Zhang Ranhao Fan Jie Gao Xiaozhong Wang; the Ethics Committee of the Second Affiliated Hospital of Nanchang University(approval numbers:(2023)CDYFYYLK(05e023)).; Pancreatic cancer(PC)is a commonly malignant tumor with a 5-year survival rate of only 10%.1 Cuproptosis is a newly discovered cell death mechanism closely associated with the development of tumors.This study mainly a...; 关键词：immune infiltration marker genes comparing expression patterns construct prognostic model prognostic model cell death mechanism cuproptosis pancreatic cancer

Molecular mechanism of tumor-infiltrating immune cells regulating endometrial carcinoma: 《Genes & Diseases》2025年第3期265-277,共13页Silu Ding Yingying Hao Yue Qi Heng Wei Jin Zhang Hui Li; Endometrial carcinoma(EC)is a prevalent gynecological cancer,and its interaction with the immune system is pivotal in cancer progression.This comprehensive review explores the molecular mechanisms involved in the regu...; 关键词：Clinical implication Endometrial carcinoma Immune checkpoint pathways Immune evasion strategies Tumor-infiltrating immune cells

Comprehensive analysis of immune subtype characterization on identification of potential cells and drugs to predict response to immune checkpoint inhibitors for hepatocellular carcinoma: 《Genes & Diseases》2025年第3期463-477,共15页Guichuan Lai Biao Xie Cong Zhang Xiaoni Zhong Jielian Deng Kangjie Li Hui Liu Yuan Zhang Anbin Liu Yi Liu Jie Fan Tianyi Zhou Wei Wang Ailong Huang; supported by the Science and Technology Research Programme Project of Chongqing Municipal Education Commission of China(No.KJQN202300423);the National Youth Science Foundation Project(China)(No.82204159);the Science and Technology Project of Sichuan Provincial Administration of Traditional Chinese Medicine(China)(No.2023MS047);the Program for Youth Innovation in Future Medicine,Chongqing Medical University(No.W0150);the Intelligent Medicine Research Project of Chongqing Medical University(No.ZHYX202223).; Immunosubtyping enables the segregation of immune responders from non-responders. However, numerous studies failed to focus on the integration of cellular heterogeneity and immunophenotyping in the prediction of hepat...; 关键词：Cellular heterogeneity Drug prediction Hepatocellular carcinoma Immune checkpoint inhibitors Immunosubtyping

Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children: 《World Journal of Diabetes》2025年第5期148-158,共11页Lan-Fang Cao Qing-Bo Xu Li Yang; Supported by Jiangxi Provincial Health Commission Science and Technology Plan,No.SKJP220212334。; BACKGROUND Early kidney damage is a significant complication in children with newly diagnosed type 1 diabetes mellitus(T1DM).Systemic inflammation plays a key role in the development of diabetic nephropathy.Several in...; 关键词：Pediatric type 1 diabetes mellitus Systemic immune inflammation index Kidney injury Urinary albumin-tocreatinine ratio Inflammatory markers

Classical biomarkers and non-coding RNAs associated with diagnosis and treatment in gastric cancer: 《Oncology Research》2025年第5期1069-1089,共21页JINGDAN QUAN ZIXIN WAN WEI WU XINYUAN CAO JIAYUAN QIU XIAOYE LIU ZHIWEI ZHANG; funded by the National Key Research and Development Project,grant number 2021YFE0192100;Natural Science Foundation of Hunan Province,grant numbers 2021JJ30694,2023JJ30529;Innovation and Entrepreneurship Training Program for College Students in Hunan Province,grant number S202210555254;Key Projects of Hunan Provincial Education Department,grant number 21A0285;Natural Science Foundation of Hunan Provincial and Municipal Co-Funding,grant number 2022JJ50029;Key Projects of Shaoyang Science and Technology Bureau,grant number 2021GZ031;Innovation and Entrepreneurship Training Program for College Students of the University of South China,grant numbers D202405212006326156,D202405210948392932,D202405211329047648,D202405221955420827.; One of the most prevalent malignant tumors worldwide,stomach cancer still has a high incidence and fatality rate in China,and the number of young people developing early-onset gastric cancer is steadily increasing.The...; 关键词：Gastric cancer Biomarkers Immune checkpoint molecules Diagnosis MicroRNA CircRNA LncRNA PIRNA

Vitiligo-like rash in a patient with lung cancer caused by sintilimab: A case report: 《World Journal of Clinical Cases》2025年第14期32-37,共6页Xiao-Ming Mao Wei-Hua Wang; BACKGROUND This article discusses a case involving a 63-year-old man with non-small cell lung cancer,who was treated with a combination of chemotherapy and immunothe-rapy.The patient was treated with five cycles of ch...; 关键词：Lung cancer VITILIGO Immune checkpoint inhibitor Sintilimab Case report

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke: 《Neural Regeneration Research》2025年第5期1277-1292,共16页Yuxiao Zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang; supported by the National Natural Science Foundation of China,Nos.82104560(to CL),U21A20400(to QW);the Natural Science Foundation of Beijing,No.7232279(to XW);the Project of Beijing University of Chinese Medicine,No.2022-JYB-JBZR-004(to XW)。; The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue regeneration.As the first i...; 关键词：BRAIN IMMUNE INFLAMMATION interaction ischemic stroke mechanism MICROGLIA NEURON secondary injury T cells

Systemic chemotherapy improves outcome of hepatocellular carcinoma patients treated with transarterial chemoembolization: 《Hepatobiliary & Pancreatic Diseases International》2025年第2期157-163,共7页Wei-Chen Zhang Ke-Yi Du Song-Feng Yu Xue-E Guo Han-Xi Yu Dong-Yan Wu Cheng Pan Cheng Zhang Jian Wu Li-Fang Bian Lin-Ping Cao Jun Yu; supported by grants from the National Natural Science Foundation of China(82270682);the Natural Science Foundation of Zhejiang Province(LQ21H030007 and LQ20H30006)。; Background:Transarterial chemoembolization(TACE)based neoadjuvant therapy was proven effective in hepatocellular carcinoma(HCC).Recently,tyrosine kinase inhibitors(TKIs)and immune checkpoint inhibitors(ICIs)also showe...; 关键词：Neoadjuvant therapy Hepatocellular carcinoma Major pathologic response Transarterial chemoembolization Tyrosine kinase inhibitors Immune checkpoint inhibitors

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