Prognostic significance and multidimensional roles of interferon regulatory factors in cancer biology:A comprehensive analysis  

作　　者：Guo Ji Shuyuan Xian Jiaqi Song Shiyu Mao Man Pi Qiongyi Huang Xue Han Jian Yin Zan Wu Runzhi Huang Dongyan Han Zhengyan Chang 

机构地区：[1]Department of Pathology,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai 200072,China [2]Department of Burn Surgery,The First Affiliated Hospital of Naval Medical University,Shanghai 200433,China [3]Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [4]Department of Urology,Shanghai Tenth People’s Hospital,School of Medicine,Tongji University,Shanghai 200072,China [5]Department of General Surgery,General Hospital of Administration Bureau for Petrolium of North China,Hebei 062552,China [6]Department of Orthopedics,Shibei Hospital,Shanghai,200443,China

出　　处：《Genes & Diseases》2025年第3期15-18,共4页基因与疾病(英文)

基　　金：supported in part by the National Natural Science Foundation of China(No.82002923,82203505).

摘　　要：Interferon regulatory factors(IRFs)are transcription factors with a conserved N-terminal helix-loop-helix DNA-binding domain 1.IRF family plays a pivotal role in regulating interferon transcription,immune cell development,cell growth,apoptosis,and oncogenesis.2 Despite considerable research,the roles of IRFs in cancer development,metastasis,drug resistance,and prognosis remain unclear.Through multidimensional correlation analysis,we examined the association between IRFs and various cancer characteristics,including clinical and immune subtype analysis,stemness,tumor microenvironment(TME),and drug sensitivity,by utilizing The Cancer Genome Atlas(TCGA)data.Moreover,the classification and prognostic role of IRF1 were further validated through immunohistochemistry staining of kidney renal papillary cell carcinoma(KIRP)clinical tissues.This research enriches our understanding of the IRFs’roles in cancer and their clinical applications.

关 键 词：interferon regulatory factors irfs interferon regulatory factors multidimensional correlation analysiswe multidimensional roles STEMNESS transcription factors immune subtype cancer biology 

分 类 号：R730.2[医药卫生—肿瘤]