STEMNESS

作品数：158被引量：389H指数：9
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相关领域：医药卫生生物学更多>>
相关作者：张厦陈策实周凯旋林勇魏金旺更多>>
相关机构：匹兹堡大学空军军医大学（第四军医大学）大连医科大学北京大学肿瘤医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金福建省自然科学基金更多>>
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Role of octamer transcription factor 4 in proliferation,migration,drug sensitivity,and stemness maintenance of pancreatic cancer cells
《World Journal of Clinical Oncology》2025年第3期83-94,共12页Xue-Ying Shi Xi-Lan Wang Jin Zhao Shi-Hai Yang Cheng-Hai Zhang 
Supported by Inner Mongolia Natural Science Foundation and the 3rd Affiliated of Inner Medical University,No.2021MS08067.
BACKGROUND Pancreatic cancer(PC)is one of the most aggressive malignancies characterized by rapid progression and poor prognosis.The involvement of cancer stem cells(CSCs)and Octamer transcription factor 4(OCT4)in PC ...
关键词：Pancreatic cancer Octamer transcription factor 4 Cancer stem cells PROLIFERATION Drug sensitivity STEMNESS 
Targeting STAT3 with SH-4-54 suppresses stemness and chemoresistance in cancer stem-like cells derived from colorectal cancer
《World Journal of Clinical Oncology》2025年第2期63-75,共13页Xu-Fan Zhang Qian Chen Qin Jiang Qiong-Ying Hu 
BACKGROUND Over the years,the numbers of treatment options for colorectal cancer(CRC)have increased,leading to notable improvements in the overall survival of CRC patients.Although therapy may initially yield positive...
关键词：SH-4-54 Colorectal cancer Cancer stem-like cells STEMNESS CHEMOSENSITIVITY 
Cascade specific endogenous Fe^(3+)interference and in situ catalysis for tumor therapy with stemness suppression
《National Science Review》2025年第2期253-269,共17页Jiajie Chen Yitong Wang Jian Huang Zhibo Yang Huicong Niu Xiaolian Su Jimin Huang Hongshi Ma Yufang Zhu Chengtie Wu Jianlin Shi 
supported by the National Key Research and De-velopment Program of China(2022YFB3804500);the Shanghai Pilot Program for Basic Research-Chinese Academy of Sciences,Shanghai Branch(JCYJ-SHFY-2022-003);the National Natu-ral Science Foundation of China(22335006 and 32101090);the China Postdoctoral Science Foundation(2024M763409);the Shanghai Rising-Star Project(Sailing Program)(24YF2753400);the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(ZDBS-LY-SLH029).
Cancer stem-li ke cel ls(CSCs),featuring high tumorigenicity and invasiveness,are one of the critical factors leading to the failure of clinical cancer treatment such as metastasis and recurrence.However,current strat...
关键词：cancer stem-likecells stemness inhibition NANOMEDICINE endogenous Fe^(3+)interference catalytic therapy 
Chronic exposure to hexavalent chromium induces esophageal tumorigenesis via activating the Notch signaling pathway
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第1期76-91,共16页Yilin ZHU Fanrong LIU Lei LIU Jinfu WANG Fengyuan GAO Lan YE Honglei WU Chengjun ZHOU Guimei LIN Xiaogang ZHAO Peichao LI 
supported by the Special Construction Project Fund for Taishan Mountain Scholars of Shandong Province;the Jinan Medicine Research Program;the Nurturing and Development Fund from The Second Hospital of Shandong University(No.2022YP62);the Shandong Provincial Natural Science Foundation for Young Scholars(No.ZR2022QH285),China.
Hexavalent chromium Cr(Ⅵ),as a well-established carcinogen,contributes to tumorigenesis for many human cancers,especially respiratory and digestive tumors.However,the potential function and relevant mechanism of Cr(...
关键词：Hexavalent chromium Cr(Ⅵ) Esophageal tumorigenesis Malignant proliferation STEMNESS Notch signaling pathway 
Post-fast refeeding:rise of intestinal stemness and mutageninduced cancer risk through polyamine metabolism
《Signal Transduction and Targeted Therapy》2024年第12期5357-5358,共2页Sarah Brunner Klaus-Peter Janssen Josef Ecker 
support from the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)project no 395357507-SFB 1371.
An increased intestinal stem cell activity following post fastrefeeding is beneficial for regeneration,but too much could increase the risk for cancer in mice,as reported in a recent study by Imada and colleagues publ...
关键词：metabolism cancer DIETARY 
N6-methyladenosine-modified long non-coding RNA KIF9-AS1 promotes stemness and sorafenib resistance in hepatocellular carcinoma by upregulating SHOX2 expression
《World Journal of Gastroenterology》2024年第48期5174-5190,共17页Yong Yu Xiang-Hong Lu Jin-Song Mu Jiang-Yun Meng Jiang-Shan Sun Hai-Xu Chen Yang Yan Ke Meng 
Supported by the National Natural Science Foundation of China,No.82271628.
BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent and aggressive tumor.Sorafenib is the first-line treatment for patients with advanced HCC,but resistance to sorafenib has become a significant challenge in this t...
关键词：Hepatocellular carcinoma STEMNESS Sorafenib resistance Long non-coding RNA KIF9-AS1 Short stature homeobox 2 
Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signaling被引量：1
《Genes & Diseases》2024年第5期470-483,共14页Zhirong Zhang Jiayao Yang Rui Liu Jing Ma Kai Wang Xiaojun Wang Ni Tang 
the National Key Research and Development Program of China(No.2023YFC2306803);the China National Natural Science Foundation(No.82273238,82272975,82072286);the Innovative and Entrepreneurial Team of Chongqing Talents Plan,Chongqing Medical Scientific Research Project(Joint Project of Chongqing Health Commission and Science and Technology Bureau;No.2023DBXM007);Senior Medical Talents Program of Chongqing for Young and Middle-aged,the Kuanren Talents and DengFeng program of the Second Affiliated Hospital of Chongqing Medical University(China),the Future Medical Youth Innovation Team of Chongqing Medical University(China)(No.W0036,W0101);the Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(No.GZC20233349).
Cancer stem cells(CSCs)play a crucial role in tumor initiation,recurrence,metastasis,and drug resistance.However,the current understanding of CSCs in hepatocellular carcinoma(HCC)remains incomplete.Through a comprehen...
关键词：Cancer stem cells HEDGEHOG Hepatocellular carcinoma METASTASIS STATIN 
The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma
《Signal Transduction and Targeted Therapy》2024年第10期4614-4627,共14页Qiaonan Shan Lu Yin Qifan Zhan Jiongjie Yu Sheng Pan Jianyong Zhuo Wei Zhou Jiaqi Bao Lincheng Zhang Jiachen Hong Jianan Xiang Qingyang Que Kangchen Chen Shengjun Xu Jingrui Wang Yangbo Zhu Bin He Jingbang Wu Haiyang Xie Shusen Zheng Tingting Feng Sunbin Ling Xiao Xu 
National Key Research and Development Program of China(2022YFA1106800),National Natural Science Foundation of China(82203070,82200726,82200727,92159202 and 82273270);Project of Medical and Health Technology Program in Zhejiang Province(2024KY853).
Lenvatinib is a targeted drug used for first-line treatment of hepatocellular carcinoma(HCC).A deeper insight into the resistance mechanism of HCC against lenvatinib is urgently needed.In this study,we aimed to dissec...
关键词：USP22 HEPATOCELLULAR diagnosis 
Integrative analysis of tumor stemness and immune microenvironment deciphers novel molecular subtypes in hepatocellular carcinoma
《Genes & Diseases》2024年第5期81-84,共4页Zhiyi Wang Shuang Chen Dongxiao Li Hui Xu Siyuan Weng Yuyuan Zhang Yuqing Ren Chunguang Guo Xiuling Li Zaoqu Liu Xinwei Han 
Hepatocellular carcinoma(HCC)is a highly heterogeneous tumor,with dynamic equilibrium and complex interplay between its intricate tumor nature and ambient tumor immune microenvironment(TIME).1 Elegant research has ind...
关键词：thereby LANDSCAPE STEM 
EZH2 is a prognostic factor associated with tumor stemness and immune infiltration in skull base chordoma
《Genes & Diseases》2024年第5期85-87,共3页Qian Liu Mingxuan Li Yujia Xiong Yutao Shen Tianshun Ma Tianhao Zhang Xiaohong R.Yang Yazhuo Zhang Jiwei Bai 
the National Natural Science Foundation of China(No.82272939,82071559);the Capital’s Funds for Health Improvement and Research(China)(2022-2Z-1076);Beijing Hospitals Authority Youth Programme of China(QML20200502).
Enhancer of zeste homolog 2(EZH2),an epigenetic regulator that inhibits transcription primarily through trimethylation of Lys-27 in histone 3(H3K27me3),has been reported to play an important role in the regulation of ...
关键词：EZH2 IMMUNITY INVASION 
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