HEPATOCELLULAR

作品数：1273被引量：7979H指数：37
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相关领域：医药卫生更多>>
相关作者：张福君张亮吴沛宏顾仰葵赵明更多>>
相关机构：第二军医大学中山大学中国人民解放军总医院广州军区广州总医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Diarylpentanoid,a curcumin analog,inhibits malignant meningioma growth in both in vitro and in vivo models
《World Journal of Experimental Medicine》2025年第2期171-184,共14页Anna Terasawa Kazuhiro Shimazu Hiroshi Nanjo Masatomo Miura Hiroyuki Shibata 
Supported by TAIHO Pharmaceutical,No.AS2023A000122715;Nippon Kayaku,No.NKCS20230416001.
BACKGROUND Malignant meningioma metastasizes systemically,primarily due to its role in epithelial-mesenchymal transition.Although the prognosis is extremely poor,drug development efforts have been limited,because this...
关键词：Malignant meningioma CURCUMIN Diarylpentanoid curcumin analog Hepatocellular growth factor Nuclear factor kappa B N-CADHERIN 
The AKT1-mTOR signaling cascade is crucial for SOX3 to promote hepatocarcinogenesis
《Genes & Diseases》2025年第2期60-63,共4页Yang Liu Feifei Song Xianhuang Zeng Siqi Yang Zixu Zhai Ze Wang Wajeeha Naz Tanzeel Yousaaf Junwei Sun Yangjun Zhang Ying Zhou Mingxiong Guo Yun-Bo Shi Geng Tian Guihong Sun 
supported by the National Natural Science Foundation of China (No.81572447,31871427,32260173);Zhongnan Hospital-Taikang Medical School (School of Basic Medical Sciences)of Wuhan University Joint Foundation (No.JCZN2022010);supported by the intramural program of Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD),National Institutes of Health (NIH),USA.
Sex-determining region Y-box protein 3(SOX3)is a member of the SoxB1 transcription factors subfamily including SOX1 and sox2,first identified based on homology to the high mobility box.1 The oncogenic potential of the...
关键词：inconsistent HEPATOCELLULAR MTOR 
Effect of portal pressure gradient reduction on outcomes after transjugular intrahepatic portosystemic shunt in portal hypertension patients
《World Journal of Hepatology》2025年第3期102-115,共14页Zhi-Bin Wang Bing Zhu Ming-Ming Meng Yi-Fan Wu Yu Zhang Dong-Ze Li Hua Tian Fu-Chuan Wang Yi-Fan Lv Qiu-Xia Ye Fu-Quan Liu 
Supported by the“14th Five-Year”Talent Training Program of Beijing Shijitan Hospital,Capital Medical University,No.2023 LJRCLFQ.
BACKGROUND Portal hypertension(PHT),a complication of liver cirrhosis,is sometimes managed with transjugular intrahepatic portosystemic shunt(TIPS)to reduce portal pressure.Although effective,TIPS poses risks,includin...
关键词：Liver cirrhosis Portal hypertension Transjugular intrahepatic portosystemic shunt Hepatic encephalopathy Liver failure CARCINOMA HEPATOCELLULAR 
Robot assisted anatomical liver resection is safe for patient with hepatocellular carcinoma underlying Fontan-associated liver disease
《Hepatobiliary & Pancreatic Diseases International》2025年第1期111-113,共3页O˘guzhan¸S al Katsunori Sakamoto Kei Tamura Masahiko Honjo Yusuke Nishi Naotake Funamizu Kohei Ogawa Yasutsugu Takada 
Fontan operation is indicated in a single ventricle congenital heart disease which creates a shunt between superior vena cava and pulmonary arteries leading to increased pressure in central venous system and congestiv...
关键词：FONTAN HEPATOCELLULAR liver 
Loss of Arhgap39 facilitates cell migration and invasion in murine hepatocellular cancer cells
《Oncology Research》2025年第2期493-503,共11页HUNG-WEI LIN PEI YU LEE YU-SHIUAN CHANG MAU-SUN CHANG 
supported by Academia Sinica(#20020)to MSC.
Background:Rho GTPases are essential regulators for cellular movement and intracellular membrane trafficking.Their enzymatic activities fluctuate between active GTP-bound and inactive GDP-bound states regulated by GTP...
关键词：Arhgap39 Hepa1-6 Hepa-1c1c7 INVASION 
RNA binding motif protein 43(RBM43)suppresses hepatocellular carcinoma metastasis by regulating Slug mRNA stability
《Genes & Diseases》2024年第6期20-23,共4页Yao Liu Huan Feng Qi Zhao Xiao Liang Ying Wang Shuai Xiao Suqin Shen Jiaxue Wu 
supported by grants from the National Natural Science Foundation of China (No.82173269 to SS,81,972,712 to JW).
RNA binding protein is a highly conserved protein family with the RNA binding domain to bind RNA and alter RNA metabolism and function.1 Abnormal expression of RNA binding protein is common in malignant tumors and con...
关键词：METABOLISM HEPATOCELLULAR INVASION 
Comment on“Clinical outcomes and histologic findings of patients with hepatocellular carcinoma with durable partial response or durable stable disease after receiving atezolizumab plus bevacizumab”
《iLIVER》2024年第4期64-65,共2页Binghua Li Qiang Wang Weiwei Hu Huan Li Peng Yan Yajuan Cao Decai Yu 
supported by grants from the National Natural Science Foundation of China(Nos.82372834 and 82173129);the Jiangsu Outstanding Youth Foundation(BK20240119).
We read with great interest the recent article by Shen et al.[1],which provides valuable insights into the outcomes and histopathologic characteristics of hepatocellular carcinoma(HCC)patients treated with atezolizuma...
关键词：(PCR) PATIENTS HEPATOCELLULAR 
Manipulating the 4-1BB Pathway to Cure HBV
《Infectious Diseases & Immunity》2024年第4期156-157,共2页Zhang Chao Wang Fu-Sheng 
supported by the National Key Research and Development Program of China(2022YFA1303600 and 2023YFC2308100);the National Natural Science Foundation of China(82130019).
Chronic Hepatitis B Virus(HBV)infection is a major global health issue leading to liver cirrhosis and hepatocellular carcinoma.Currently available treatments have limited efficacy in completely eradicating the virus.
关键词：CIRRHOSIS INFECTION HEPATOCELLULAR 
Surgical treatment strategies for multifocal hepatocellular carcinomas
《Hepatobiliary Surgery and Nutrition》2024年第6期1071-1076,共6页Xuehai Jia Anque Liao Li Jiang 
supported by the National Natural Science Foundation of China(No.82470652 to L.J.);Sichuan Province Key Research and Development Project(No.2019YFS0203 to L.J.);Key Clinical Research Incubation Project of West China Hospital of Sichuan University(No.2020HXFH028 to L.J.);Key R&D Support Plan of Chengdu Science and Technology Bureau(No.2021-YF05-00703-SN to L.J.);Sichuan Province Key Research and Development Project(No.2022YFS0090 to L.J.);Sichuan Natural Science Foundation project(No.24NSFSC0237 to L.J.).
The multifocality of hepatocellular carcinoma(HCC)still represents considerable challenges,with generally poorer outcomes compared to the single HCC(SH).According to the Barcelona Clinic Liver Cancer(BCLC)guideline,on...
关键词：MULTIFOCAL HEPATOCELLULAR LIVER 
Chinese expert consensus on clinical application of molecularly targeted drugs for hepatocellular carcinoma(2022 edition)
《Chinese Medical Journal》2024年第21期2630-2632,共3页Juxian Sun Qiu Li Xueli Bai Jianqiang Cai Yajin Chen Minshan Chen Chaoliu Dai Chihua Fang Weidong Jia Xiangcheng Li Tianfu Wen Jinglin Xia Mingang Ying Zhiwei Zhang Xuewen Zhang Zhaochong Zeng Shuqun Cheng On behalf of Chinese Association of Liver Cancer and Chinese Medical Doctor Association 
supported by grants from the State Key Project of the National Natural Science Foundation of China(No.81730097);the Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center(Joint Project of Emerging Frontier Technology)(No.SHDC12018116);the Clinical Research Plan of Shanghai Hospital Development Center(No.SHDC2020CR1004A).
To the Editor:Primary liver cancer is one of the most common malignant tumors in China.In 2020,410,038 new cases of liver cancer and 391,152 deaths due to liver cancer were reported in China,which places liver cancer ...
关键词：HEPATOCELLULAR DRUGS cancer 
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