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Sesquiterpene lactones as potential drugs treating nerve injury: 《Neural Regeneration Research》2026年第2期671-672,共2页Philipp Gobrecht Marco Leibinger Dietmar Fischer; supported by The German Research Foundation.; Traumatic axonal lesions of peripheral nerves disrupt neuronal connections with their targets,resulting in the loss of motor and sensory functions.Despite the peripheral nervous system’s capacity for axonal regrowth,...; 关键词：traumatic axonal lesions peripheral nervous system s axonal regrowththis permanent impairements nerve injury peripheral nerves disrupt neuronal connections sesquiterpene lactones

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease: 《Neural Regeneration Research》2025年第10期2823-2837,共15页Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing Ren Chenguang Zheng Jiajia Yang Dong Ming; supported by the National Natural Science Foundation of China,Nos.82371886(to JY),81925020(to DM),82202797(to LW),and 82271218(to CZ).; Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive deterioration.The presence of the blood-brain barrier presents a major obstacle to the dev...; 关键词：Alzheimer’s disease blood-brain barrier DRUGS magnetic resonance imaging-guided focused ultrasound MICROBUBBLES scanning ultrasound ULTRASOUND ultrasound stimulation

Sotatercept:A novel therapeutic approach for pulmonary arterial hypertension through transforming growth factor-βsignaling modulation: 《World Journal of Methodology》2025年第3期63-69,共7页Jyoti Bajpai Mehul Saxena Akshyaya Pradhan Surya Kant; Pulmonary arterial hypertension(PAH)is a progressive disease marked by degeneration of the lung’s blood vessels.As the disease progresses,the resistance to blood flow in the pulmonary arteries increases,putting a str...; 关键词：Pulmonary artery DRUGS Mean pulmonary artery pressure Transforming growth factor-βpathway PROTEIN

Comprehensive analysis of immune subtype characterization on identification of potential cells and drugs to predict response to immune checkpoint inhibitors for hepatocellular carcinoma: 《Genes & Diseases》2025年第3期463-477,共15页Guichuan Lai Biao Xie Cong Zhang Xiaoni Zhong Jielian Deng Kangjie Li Hui Liu Yuan Zhang Anbin Liu Yi Liu Jie Fan Tianyi Zhou Wei Wang Ailong Huang; supported by the Science and Technology Research Programme Project of Chongqing Municipal Education Commission of China(No.KJQN202300423);the National Youth Science Foundation Project(China)(No.82204159);the Science and Technology Project of Sichuan Provincial Administration of Traditional Chinese Medicine(China)(No.2023MS047);the Program for Youth Innovation in Future Medicine,Chongqing Medical University(No.W0150);the Intelligent Medicine Research Project of Chongqing Medical University(No.ZHYX202223).; Immunosubtyping enables the segregation of immune responders from non-responders. However, numerous studies failed to focus on the integration of cellular heterogeneity and immunophenotyping in the prediction of hepat...; 关键词：Cellular heterogeneity Drug prediction Hepatocellular carcinoma Immune checkpoint inhibitors Immunosubtyping

DARG:An integrated knowledge base for analyzing addictive drug-related genes: 《Genes & Diseases》2025年第2期140-142,共3页Xu Wang Bei Yun Zihan Zhang Xiaoxi Wang Yifan Wu Yubo Hu Shiyi Fang Junjie Lv Lina Chen Wan Li; supported by the Natural Science Foundation of Heilongjiang Province,China (No.LH2021F043);the National Natural Science Foundation of China (No.61702141).; Drug addiction is a complex brain disease closely related to the expression and methylation of many genes.Differential genes can influence addiction,and some key differential genes may have a significant impact on the...; 关键词：DRUGS DIC ADDICTION

The effect of concomitant drugs on oncological outcomes in patients treated with immunotherapy for metastatic urothelial carcinoma:a narrative review: 《Oncology Research》2025年第4期741-757,共17页MICHELE MAFFEZZOLI GIULIA CLAIRE GIUDICE GIACOMO IOVANE MARTINA MANINI ELENA RAPACCHI GIUSEPPE CARUSO NICOLA SIMONI STEFANIA FERRETTI STEFANO PULIATTI DAVIDE CAMPOBASSO SEBASTIANO BUTI; Background:immune checkpoint inhibitors(ICIs)have revolutionized the treatment of metastatic urothelial carcinoma(mUC),significantly improving survival outcomes.However,a subset of patients do not respond to ICIs,prom...; 关键词：Immune checkpoint inhibitors(ICIs) Urothelial carcinoma(UC) Concomitant drugs Proton pump inhibitors Antibiotics(Abs) Angiotensinconverting enzyme inhibitors(ACEIs)

Analysis of 979 cases of adverse drug reactions induced by antineoplastic drugs: 《Journal of Chinese Pharmaceutical Sciences》2025年第3期223-231,共9页Xingnong Xu Doudou He Lei Ma; Collaborative Innovation Program of Jiangsu Pharmaceutical Vocational College(Grant No.20239120)。; The aim of this study is to evaluate the characteristics and patterns of adverse drug reactions(ADRs)associated with antineoplastic drugs and provide insights for safer chemotherapy practices.Based on 979 ADR cases re...; 关键词：Anti-tumor drugs Adverse effects Drug safety

药物相互作用分析软件性能的量化评估与思考: 《药物评价研究》2025年第3期566-575,共10页袁如月刘岩杨天绎张力赵志刚李新辰李皎月黄举凯杨晓晖; 中国药品监督管理研究会研究课题-基于多元证据体探索中成药安全性评价方法的研究(2024-Y-Y-006);临床研究和成果转化能力提升试点项目-中药制剂研发——治疗胃轻瘫中药复方佛香散(DZMG-ZJXY-23002)。; 目的采用多维度定量评估国外5个常用药物相互作用(DDI)分析软件的性能,为我国DDI软件开发提供参考。方法对DDI分析软件的评估涵盖4个维度,即准确性、全面性、易用性、可靠性,准确性采用诊断性Meta分析方法对敏感度、特异度等数据进行定...; 关键词：药物相互作用软件性能评估合理用药 Micromedex DrugReax^(®) Lexicomp Interactions Epocrates Drug Interactions Checker(Drugs.com) Medscape^(®)

Analysis of the Trend in the Consumption of Psychoactive Substances in Senegal from 2018 to 2022: 《Open Journal of Epidemiology》2025年第1期36-49,共14页Jean Augustin Diégane Tine Kadidiatou Diarra Amadou Ibra Diallo Ibrahima Seck; Purpose: The aim of the study was to investigate the profile of psychoactive substance users in Senegal from 2018 to 2022. Methodology: These were retrospective descriptive studies of patient consultation and hospital...; 关键词：CONSUMPTION Substance Psychoactive DRUGS Senegal

The effects of Urgently Needed Overseas Drugs on the launch delay of new drugs in China: 《Pharmacoeconomics and Policy》2025年第1期15-20,共6页Xingyue Zhu Yang Chen; The Chinese drug agency has issued the Urgently Needed Overseas Drug(UNOD)lists since 2018,which allows drugs to be approved based on overseas trial data,to address drug delays.We aimed to evaluate the effects of the ...; 关键词：Drug lag Launch delay Drug access Instrumental variables

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