Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease  

作　　者：Qiuquan Cai Lianghui Meng Meina Quan Ling Wang Jing Ren Chenguang Zheng Jiajia Yang Dong Ming 

机构地区：[1]Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin,China [2]Innovation Center for Neurological Disorders,Xuanwu Hospital,Capital Medical University,Beijing,China [3]Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory,Tianjin University,Tianjin,China [4]Tianjin Key Laboratory of Brain Science and Neural Engineering,Tianjin University,Tianjin,China

出　　处：《Neural Regeneration Research》2025年第10期2823-2837,共15页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,Nos.82371886(to JY),81925020(to DM),82202797(to LW),and 82271218(to CZ).

摘　　要：Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive deterioration.The presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s disease.The use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent years.As a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive deficits.This article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound therapy.Emphasis is placed on the benefits of introducing these treatment methods and their potential mechanisms.We found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque deposition.We believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关 键 词：Alzheimer’s disease blood-brain barrier DRUGS magnetic resonance imaging-guided focused ultrasound MICROBUBBLES scanning ultrasound ULTRASOUND ultrasound stimulation 

分 类 号：R749.16[医药卫生—神经病学与精神病学]