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PROTEIN: 作品数：2328被引量：5787H指数：25; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：邢苗李根喜刘晓灵梁毅杨芃原更多>>; 相关机构：中国科学院北京大学第二军医大学复旦大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

ABCA5 lipid transporter is associated with a reduced risk of Parkinson’s disease: 《Neural Regeneration Research》2026年第2期669-670,共2页Jasmin Galper Nicolas Dzamko Woojin Scott Kim; A key pathological feature of Parkinson’s disease(PD)is that lysosomes are overwhelmed with cellular materials that need to be degraded and cleared.While the build-up of protein is characteristic of neurodegenerative...; 关键词：neurodegenerative diseases lipid transporter abca LYSOSOME protein build up Alzheimers disease cellular materials Parkinsons disease

Sotatercept:A novel therapeutic approach for pulmonary arterial hypertension through transforming growth factor-βsignaling modulation: 《World Journal of Methodology》2025年第3期63-69,共7页Jyoti Bajpai Mehul Saxena Akshyaya Pradhan Surya Kant; Pulmonary arterial hypertension(PAH)is a progressive disease marked by degeneration of the lung’s blood vessels.As the disease progresses,the resistance to blood flow in the pulmonary arteries increases,putting a str...; 关键词：Pulmonary artery DRUGS Mean pulmonary artery pressure Transforming growth factor-βpathway PROTEIN

Hereditary alpha tryptasemia and clinical implications: 《World Journal of Clinical Cases》2025年第21期6-15,共10页Ece TüsüzÖnata ÖnerÖzdemir Süreyya Savaşan; Hereditary alpha tryptasemia was first described in 2016 and is the most common(up to 72%)cause of elevated serum basal tryptase(TPS).The clinical presentation of this condition,which is caused by copy number gains in...; 关键词：Tryptasemia Autosomal dominant Hereditary alpha tryptasemia Mast cell Tyrosine kinase protein

Curly leaf 1,a CHD domain-containing protein,regulates leaf development by H3K27me3 modification in rice: 《The Crop Journal》2025年第2期360-371,共12页Jingyan Yang Yatong Chen Xiaowei Sun Xiaoyue Zhang Shiyu Wang Yanpeng Lyu Yanjuan Hu Xiaoxue Wang; supported by the National Natural Science Foundation of China(32070642 and 31371222 to Dr.Xiaoxue Wang);the National Key Research and Development Program from the Ministry of Science and Technology of China(2016YFD0100406 and 2017YFD0300107 to Dr.Xiaoxue Wang);the Science and Technology Department of Liaoning province(2022JH6/100100039 to Dr.Xiaoxue Wang)。; The leaf is a major organ for photosynthesis,and its shape plays an important role in plant development and yield determination in rice(Oryza sativa L.).In this study,an adaxial curled leaf mutant,termed curly leaf 1-...; 关键词：Curly leaf 1 cul1-1 Leaf rolling CHD protein H3K27me3 H3K4me3 RICE

Targeting mixed lineage kinase domain-like protein's nonnecroptosis role:A new horizon in anti-inflammatory therapy for alcoholic liver disease: 《World Journal of Gastroenterology》2025年第13期158-162,共5页Yue Xi Dong Guo Shi Li Jie-Yu Guo Xing-Zhen Chen Jing-Feng Tang Ce-Fan Zhou; Although mixed lineage kinase domain-like protein(MLKL)is widely recognized as a critical effector in the necroptotic signaling pathway,MLKL plays broader regulatory roles beyond programmed necroptosis.Notably,Xuan Yu...; 关键词：Mixed lineage kinase domain-like protein ATP-binding pocket CPD4 inhibitor Alcoholic liver disease Therapeutic targets Liver diseases

Ali-A1 and TPL1 proteins interactively modulate awn development in wheat: 《The Crop Journal》2025年第2期468-479,共12页Linyi Qiao Tian Li Shujuan Liu Xueqi Zhang Min Fan Xiaojun Zhang Xin Li Zujun Yang Juqing Jia Ling Qiao Zhijian Chang Liuling Yan; supported by the Grand Science and Technology Special Project in Shanxi Province(202201140601025-2);the National Natural Science Foundation of China(32201749);supported by the Agriculture and Food Research Initiative Competitive Grant 2022-68013-36439(WheatCAP)from the USDA National Institute of Food and Agriculture.; The awn can contribute to photosynthesis and carbohydrates,enhancing grain yield in wheat.We mapped QAwn.sxau-5A,a major QTL for awn development in wheat(Triticum aestivum).This QTL was delimited to a 994-kb interval ...; 关键词：ALI protein TPL protein Awn AUXIN WHEAT

Mixed lineage kinase domain-like protein in liver diseases:Cell-typespecific functions and dual roles: 《World Journal of Gastroenterology》2025年第14期161-167,共7页Ming-Xing Liang Ying Zhou Su-Qun Li Wan-Sheng Xiang Zong-Qin Pan Ying-Hua Chen Yi-Huai He; Supported by the Science and Technology Planning Projects of Guizhou Province,No.QKHJC-ZK[2022]YB642;Health Research Project of Guizhou Province,No.gzwkj2024-324,and No.gzwkj2024-103;WBE Liver Fibrosis Foundation,No.CFHPC2025028;Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund,No.iGandanF-1082024-Rgg018;Student Innovation and Entrepreneurship Training Program of Zunyi Medical University,No.S2024106612360.; In this letter,we comment on the article by Xuan Yuan et al,published in the recent issue of the World Journal of Gastroenterology.Mixed lineage kinase domainlike protein(MLKL)exhibits cell-type-specific functions in ...; 关键词：Cell-type-specific functions Dual roles Liver diseases Mixed lineage kinase domain-like protein NECROPTOSIS

Salmonella Yrb D protein mediates invasion into the host by interacting withβ2 integrin: 《Journal of Integrative Agriculture》2025年第3期1181-1197,共17页Jun Cao Jinliang Wang Guanghui Dang Shihao Ding Yao Lu Qiu Xu Siguo Liu Shenye Yu; supported by the National Key R&D Program of China(2022YFF0710500);the the National Natural Science Foundation,China(31802192,32172853 and 32373013);the Natural Science Foundation of Heilongjiang Province of China(C2018070);China Postdoctoral Science Foundation(2017M620076);the Central Public-interest Scientific Institution Basal Research Fund,China(1610302022001)。; Salmonella enterica serovar Typhimurium,the causative agent of gastroenteritis,is one of the most successful intracellular pathogens.Although certain host factors for Salmonella infection have been unveiled,the factor...; 关键词：β2 integrin adhesion INTERNALIZATION SALMONELLA protein Yrb D

Highly Accurate and Efficient Deep Learning Paradigm for Full-Atom Protein Loop Modeling with KarmaLoop: 《Research》2025年第1期823-839,共17页Tianyue Wang Xujun Zhang Odin Zhang Guangyong Chen Peichen Pan Ercheng Wang Jike Wang Jialu Wu Donghao Zhou Langcheng Wang Ruofan Jin Shicheng Chen Chao Shen Yu Kang Chang-Yu Hsieh Tingjun Hou; supported by the National Key Research and Development Program of China(2022YFF1203000);the National Natural Science Foundation of China(22220102001,82204279,22007082,and 62006219);the Fundamental Research Funds for the Central Universities(226-2022-00220);the Natural Science Foundation of Zhejiang Province(LQ21B030013);Hong Kong Innovation and Technology Fund(Project No.ITS/241/21).; Protein loop modeling is a challenging yet highly nontrivial task in protein structure prediction.Despite recent progress,existing methods including knowledge-based,ab initio,hybrid,and deep learning(DL)methods fall s...; 关键词：deep learning dl methods accuracy karmaloop deep learning protein loop modeling protein structure predictiondespite full atom modeling

Irreversible electroporation combined with anti-programmed cell death protein 1 therapy promotes tumor antigen-specific CD8+T cell response: 《World Journal of Gastrointestinal Oncology》2025年第3期237-245,共9页Yang-Yang Ma Xiao-Hua Wang Jian-Ying Zeng Ji-Bing Chen Li-Zhi Niu; Science and Technology Program of Guangzhou,No.202102010077;International Science Foundation of Guangzhou Fuda Cancer Hospital,No.Y2020-ZD-03.; BACKGROUND Irreversible electroporation(IRE)is a novel local tumor ablation approach with the potential to activate the host’s immune system.However,this approach is insufficient to prevent cancer progression,and com...; 关键词：Irreversible electroporation Pancreatic cancer Programmed cell death protein 1 blockade CD8+T cell Anticancer immunity

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