NECROPTOSIS

作品数：167被引量：1184H指数：15
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Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury
《Neural Regeneration Research》2025年第11期3273-3286,共14页Shiming Li Jianfeng Li Guoliang Chen Tao Lin Penghui Zhang Kuileung Tong Ningning Chen Shaoyu Liu 
supported by the National Natural Science Foundation of China,No.81801907(to NC);Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research,No.ZDSYS20230626091402006(to NC);Sanming Project of Medicine in Shenzhen,No.SZSM201911002(to SL);Foundation of Shenzhen Committee for Science and Technology Innovation,Nos.JCYJ20230807110310021(to NC),JCYJ20230807110259002(to JL);Science and Technology Program of Guangzhou,No.2024A04J4716(to TL)。
We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord injury.While exosomes are recognized as playing a pivotal role in neural stem cells exocrine func...
关键词：cellular communication competing endogenous RNA EXOSOMES Foxp1 NECROPTOSIS neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2 
Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials
《Neural Regeneration Research》2025年第8期2245-2263,共19页Run Song Shiyi Yin Jiannan Wu Junqiang Yan 
supported by the Key Projects of Medical Science and Technology of Henan Province,No.SBGJ202002099(to JY)。
Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulat...
关键词：apoptosis autophagy cuproptosis disulfidptosis ferroptosis NECROPTOSIS neurodegenerative disease neurological aging diseases PANoptosis PYROPTOSIS 
Mixed lineage kinase domain-like protein in liver diseases:Cell-typespecific functions and dual roles
《World Journal of Gastroenterology》2025年第14期161-167,共7页Ming-Xing Liang Ying Zhou Su-Qun Li Wan-Sheng Xiang Zong-Qin Pan Ying-Hua Chen Yi-Huai He 
Supported by the Science and Technology Planning Projects of Guizhou Province,No.QKHJC-ZK[2022]YB642;Health Research Project of Guizhou Province,No.gzwkj2024-324,and No.gzwkj2024-103;WBE Liver Fibrosis Foundation,No.CFHPC2025028;Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund,No.iGandanF-1082024-Rgg018;Student Innovation and Entrepreneurship Training Program of Zunyi Medical University,No.S2024106612360.
In this letter,we comment on the article by Xuan Yuan et al,published in the recent issue of the World Journal of Gastroenterology.Mixed lineage kinase domainlike protein(MLKL)exhibits cell-type-specific functions in ...
关键词：Cell-type-specific functions Dual roles Liver diseases Mixed lineage kinase domain-like protein NECROPTOSIS 
Adenosine triphosphate-binding pocket inhibitor for mixed lineage kinase domain-like protein attenuated alcoholic liver disease via necroptosis-independent pathway
《World Journal of Gastroenterology》2025年第6期44-61,共18页Han-Ning Xuan Yuan Hyun Sung Kim Gye Ryeol Park Jae Eun Ryu Ji Eun Kim In Young Kang Hye Young Kim Seung Min Lee Ju Hee Oh Eileen L Yoon Dae Won Jun 
Supported by the National Research Foundation of Korea Grant Funded by the Korea Government,No.RS-2024-00440477;the Korea Institute of Science and Technology Institutional Program,No.2E33111-24-042.
BACKGROUND Mixed lineage kinase domain-like protein(MLKL)serves as a critical mediator in necroptosis,a form of regulated cell death linked to various liver diseases.This study aims to specifically investigate the rol...
关键词：RAW 264.7 cell Cell death NECROPTOSIS Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Mixed lineage kinase domain-like protein adenosine triphosphate binding inhibitor Alcoholic liver disease 
Battling pain from osteoarthritis:causing novel cell death
《Acta Biochimica et Biophysica Sinica》2025年第2期169-181,共13页Yuheng Zhang Huaqiang Tao Liyuan Zhang Xueyan Li Yi Shi Wen Sun Wenlong Chen Yuhu Zhao Liangliang Wang Xing Yang Chengyong Gu 
supported by the grants from the Program of Jiangsu Science and Technology Department(Nos.BK20211083 and BE2022737);the Program of Suzhou Health Commission(Nos.GSWS2020078,SZXK202111,and GSWS2022002);the Program of Suzhou Science and Technology Department(No.SKY202306).
Osteoarthritis(OA)is a significant contributor to pain and disability worldwide.Pain is the main complaint of OA patients attending the clinic and has a large impact on their quality of life and economic standards.How...
关键词：OSTEOARTHRITIS PAIN cell death PYROPTOSIS ferroptosis NECROPTOSIS 
Necroptosis contributes to deoxynivalenolinduced liver injury and inflammation in weaned piglets
《Journal of Animal Science and Biotechnology》2025年第1期182-192,共11页Qilong Xu Hanqiu Gong Mohan Zhou Junjie Guo Shaokui Chen Kan Xiao Yulan Liu 
Project of National Natural Science Foundation of China(U22A20517 and 32272906).
Background The aim of this study was to investigate the role of necroptosis in deoxynivalenol(DON)-induced liver injury and inflammation in weaned piglets.Methods In Exp.1,12 weaned piglets were divided into 2 groups ...
关键词：DEOXYNIVALENOL Liver damage NECROPTOSIS Necrostatin-1 PIGS 
METTL3 restricts RIPK1-dependent cell death via the ATF3-cFLIP axis in the intestinal epithelium
《Cell Regeneration》2024年第1期238-252,共15页Meimei Huang Xiaodan Wang Mengxian Zhang Yuan Liu Ye‑Guang Chen 
National Natural Science Foundation of China(31988101 to YGC,92354306 to YL);National Key Research and Development Program of China(2023YFA1800603);Natural Science Foundation of Jiangxi Province(20224ACB209001);Beijing Science and Technology Plan(Z231100007223006);Shenzhen Medical Research Fund(B2302022)to YGC.
Intestinal epithelial cells(IECs)are pivotal for maintaining intestinal homeostasis through self-renewal,proliferation,differentiation,and regulated cell death.While apoptosis and necroptosis are recognized as distinc...
关键词：APOPTOSIS NECROPTOSIS Intestinal homeostasis Mettl3 m6A modification RIPK1 
Iron promotes both ferroptosis and necroptosis in the early stage of reperfusion in ischemic stroke被引量：1
《Genes & Diseases》2024年第6期495-509,共15页Bin Du Zijie Deng Kang Chen Zhangzhong Yang Junfen Wei Liuyao Zhou Jie Meng Ying Cheng Xin Tian Qing-Zhang Tuo Peng Lei 
upported by the National Key Research and Development Program of China (No.2021YFC2500100);1.3.5 Project for Disciplines of Excellence of West China Hospital of Sichuan University (No.ZYYC23016);the Key Research Projects of Sichuan Province,China (No.24SYSX0093);Major Science&Technology Program of Sichuan Province,China (No.2022ZDZX0021);the National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University (China) (No.Z2023LC005);the Natural Science Foundation of Sichuan Province,China (No.2022NSFSC1509);the Fundamental Research Funds for the Central Universities (China) (No.2023SCU12074).
Programmed cell death contributes to neurological damage in ischemic stroke,especially during the reperfusion stage.Several cell death pathways have been tested preclinically and clinically,including ferroptosis,necro...
关键词：DEFEROXAMINE Ferroptosis IRON Ischemic stroke NECROPTOSIS 
Parkin deficiency aggravates inflammation-induced acute lung injury by promoting necroptosis in alveolar type Ⅱ cells
《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第4期265-278,共14页Meiyu Quan Qiang Guo Xihua Yan Chenhua Yu Linglong Yang Yuting Zhang Jiaqi Li Qiongxia Weng Bin Liu Quan Li Li Dong Junjie Chen Zhenkun Lou Xuru Jin Chengshui Chen Jin-San Zhang 
supported by the National Natural Science Foundation of China(Nos.82370085 and 82170017 to CC);funding from the Zhejiang Province Public Welfare Fund Project(No.LY24H050003);the Discipline Cluster of Oncology at Wenzhou Medical University,China(No.Z1-2023004);startup research funds from both the Quzhou Affiliated Hospital and The First Affiliated Hospital of Wenzhou Medical University。
Background: Necroptosis is a form of programmed cell death resulting in tissue inflammation due to the release of intracellular contents. Its role and regulatory mechanism in the context of acute lung injury (ALI) are...
关键词：Acute lung injury PARKIN NECROPTOSIS Alveolar type 2(AT2)cells INFLAMMATION Fibrosis Transgenic mouse models 
MLKL-mediated endothelial necroptosis drives vascular damage and mortality in systemic inflammatory response syndrome被引量：1
《Cellular & Molecular Immunology》2024年第11期1309-1321,共13页Xiaoxia Wu Xiaoming Zhao Fang Li Yang Wang Yangjing Ou Haiwei Zhang Xiaoming Li Xuanhui Wu Lingxia Wang Ming Li Yue Zhang Jianling Liu Mingyan Xing Han Liu Yongchang Tan Yangyang Wang Yangyang Xie Hanwen Zhang Yan Luo Hong Li Jing Wang Liming Sun Yu Li Haibing Zhang 
supported by grants from the National Key Research and Development Program of China(2022YFA0807300);the National Natural Science Foundation of China(32270803,32300630,82272181,T2293734);the Shanghai Excellent Academic/Technical Leader Program(22XD1404500);the Shanghai Science and Technology Commission(23141902800);the China Postdoctoral Science Foundation(2020M671261).
The hypersecretion of cytokines triggers life-threatening systemic inflammatory response syndrome(SIRS),leading to multiple organ dysfunction syndrome(MODS)and mortality.Although both coagulopathy and necroptosis have...
关键词：Systemic inflammatory response syndrome(SIRS) Endothelial cells RIPK3 MLKL NECROPTOSIS TNF-α 
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