云南高校图书馆联盟文献共享服务平台- OSTEOARTHRITIS

OSTEOARTHRITIS: 作品数：686被引量：2332H指数：20; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：吴岩徐小洁欧阳宏伟冀全博夏青青更多>>; 相关机构：中南大学复旦大学上海交通大学附属第六人民医院军事医学科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划广东省自然科学基金更多>>

Optimizing bone marrow harvesting sites for enhanced mesenchymal stem cell yield and efficacy in knee osteoarthritis treatment: 《World Journal of Methodology》2025年第2期92-107,共16页Arulkumar Nallakumarasamy Sandeep Shrivastava Ravi Velamoor Rangarajan Naveen Jeyaraman Avinash Gandi Devadas Swaminathan Ramasubramanian Madhan Jeyaraman; Knee osteoarthritis(OA)is a debilitating condition with limited long-term treatment options.The therapeutic potential of mesenchymal stem cells(MSCs),particularly those derived from bone marrow aspirate concentrate,ha...; 关键词：KNEE OSTEOARTHRITIS Mesenchymal stem cells Bone marrow harvest Regenerative medicine

AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration: 《中国组织工程研究》2025年第17期3537-3547,共11页Yu Yangyi Song Zhuoyue Lian Qiang Ding Kang Li Guangheng; 国家自然科学基金面上项目(81472136),项目负责人:李广恒。; BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent years.However,given the complexity of osteoarthritis pathogenesis,single gene ma...; 关键词：OSTEOARTHRITIS adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes.

Human umbilical cord mesenchymal stem cell-derived exosomal miR-199a-3p inhibits the MAPK4/NF-κB signaling pathway to relieve osteoarthritis: 《World Journal of Stem Cells》2025年第4期113-135,共23页Ling-Qiang Chen Sha Ma Juan Yu Da-Chen Zuo Zi-Jing Yin Fa-You Li Xia He Hai-Ting Peng Xiao-Qing Shi Wei-Juan Huang Qin Li Jing Wang; Supported by Basic Research Plan of Yunnan Province,No.202201AT070059;National Natural Science Foundation of China,No.81760407;Science and Technology Talent and Platform Plan of Yunnan Provincial Department of Science and Technology,No.202205AC160066.; BACKGROUND There is currently no effective treatment for osteoarthritis(OA),which is the most common joint disorder leading to disability.Although human umbilical cord mesenchymal stem cells(hUC-MSCs)are promising OA ...; 关键词：OSTEOARTHRITIS Human umbilical cord mesenchymal stem cells EXOSOMES MiR-199a-3p Mitogen-activated protein kinase 4 Nuclear factor-kappaB

Lower limb coordination patterns following anterior cruciate ligament reconstruction:A longitudinal study: 《Journal of Sport and Health Science》2025年第2期126-134,共9页Cortney Armitano-Lago Elizabeth Bjornsen Caroline Lisee Ashley Buck Christin Buttner Adam W.Kiefer Todd A.Schwartz Brian Pietrosimone; supported by the Arthritis Foundation(principal investigator:BP);the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health(P30-AR072580)。; Background:Changes in lower limb joint coordination have been shown to increase localized stress on knee joint soft tissue—a known precursor of osteoarthritis.While 50%of individuals who undergo anterior cruciate lig...; 关键词：Cross-recurrence quantification analysis GAIT COORDINATION OSTEOARTHRITIS Nonlinear dynamics

The miR-6779/XIAP axis alleviates IL-1β-induced chondrocyte senescence and extracellular matrix loss in osteoarthritis: 《Animal Models and Experimental Medicine》2025年第4期662-673,共12页Zongchao Li Aonan Dai Xiaoxiang Fang Kexing Tang Kun Chen Peng Gao Jingyue Su Xin Chen Shengwu Yang Zhenhan Deng Liangjun Li; Natural Science Foundation of Changsha city,China,Grant/Award Number:kq2403166;Hunan Provincial Clinical Medical Technology Innovation Guiding Project,Grant/Award Number:2020SK53307;Basic Public Welfare Research projects of Wenzhou Science and Technology Bureau,Grant/Award Number:Y20240087;Natural Science Foundation of Hunan Province,Grant/Award Number:2020JJ8043;Start-up Funding for Talented Scientific Research of the First Affiliated Hospital of Wenzhou Medical University,Grant/Award Number:2023QD026;Key Project of Hunan Provincial Health Commission,Grant/Award Number:20201902 and C2019133;National Natural Science Foundation of China,Grant/Award Number:82472495。; Background:Osteoarthritis(OA)is a long-term degenerative joint disease worsen-ing over time.Aging and chondrocyte senescence contribute to OA progression.MicroRNAs have been confirmed to regulate different cellular pr...; 关键词：CHONDROCYTE miR-6779 OSTEOARTHRITIS SENESCENCE X-linked inhibitor of apoptosis protein

Impact of preoperative factors on clinical outcomes after total hip arthroplasty: 《World Journal of Orthopedics》2025年第4期30-35,共6页Toru Nishiwaki Hisatoshi Ishikura Yuji Masuyama Sho Fujita Rei Hirose; BACKGROUND Although total hip arthroplasty(THA)is an established intervention for advanced hip disorders,not all patients achieve the anticipated functional improvements.AIM To investigate the impact of various preope...; 关键词：Modified Harris Hip Score Western Ontario and McMaster Universities Osteoarthritis Index Central sensitization Neuropathic pain Total hip arthroplasty

Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis: 《Genes & Diseases》2025年第2期383-397,共15页Changyuan Huangg Bin Zeng Bo Zhou Guanming Chen Qi Zhang Wenhong Hou Guozhi Xiao Li Duan Ni Hong Wenfei Jin; supported by the National Key R&D Program of China (No.2021YFF1200900);National Natural Science Foundation of China (No.32170646,8197211);Guangdong Basic and Applied Basic Research Foundation (China) (No.2023A1515011908 to N.H.);Key-Area Research and Development Program of Guangdong Province,China (No.2023B1111020006);International Science and Technology CooperationnProgramnofGuangdong,China (No.2021A0505030011);Shenzhen Innovation Committee of Science and Technology (Guangdong,China) (No.JCYJ20220818100401003);Shenzhen Science and Technology Program (Guangdong,China) (No.SGDX20201103095800003,GJHZ20200731095606019,JCYJ20220818100401003);Shenzhen High-level Hospital Construction Fund (Guangdong,China) (No.1801004).; Chondrocyte is considered the only cell type in cartilage.However,the cell hetero-geneity of chondrocytes in human articular cartilage is still not well defined,which hinders our understanding of the pathogenesis of o...; 关键词：Cell heterogeneity Chondrocyte apoptosis Chondrocyte differentiation Chondrocyte fibrosis OSTEOARTHRITIS Single-cell RNA-seq

Requirements for standardizing the assessment of mesenchymal stem cell therapy and its effects on osteoarthritis: 《World Journal of Orthopedics》2025年第3期115-120,共6页Yu-Chen Wang Jing-Bo Cheng Ming-Li Feng; Supported by Capital Fund Project for Clinical Diagnosis and Treatment Technology Research and Translational Application,No.Z201100005520091.; Publications of Soufan et al and Kristjánsson et al in the World Journal of Orthopedics on mesenchymal stem cell(MSC)therapy for osteoarthritis(OA)represent a significant exploration of regenerative medicine’s poten...; 关键词：OSTEOARTHRITIS Mesenchymal stem cell therapy ASSESSMENT HETEROGENEITY SAFETY

Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment: 《International Journal of Oral Science》2025年第1期66-81,共16页Wenxiu Yuan Jiaqi Liu Zhenzhen Zhang Chengxinyue Ye Xueman Zhou Yating Yi Yange Wu Yijun Li Qinlanhui Zhang Xin Xiong Hengyi Xiao Jin Liu Jun Wang; supported by National Natural Science Foundation of China(Nos.82271019,82472149,82471024);Sichuan Science and Technology Program(No.24ZDYF0099);Research and Develop Program,West China Hospital of Stomatology Sichuan University(RD-03-202101)to J.W.; The ambiguity of etiology makes temporomandibular joint osteoarthritis(TMJOA)“difficult-to-treat”.Emerging evidence underscores the therapeutic promise of exosomes in osteoarthritis management.Nonetheless,challenges...; 关键词：OSTEOARTHRITIS ELEVATED LOADING

Efficacy equivalence but hidden hurdles:Can serum-free human umbilical cord mesenchymal stem cells translate to clinically superior osteoarthritis therapy: 《World Journal of Stem Cells》2025年第3期144-146,共3页Fang Lin Ke-Xin Ma Yue Ding Xiao-Ting Liang; Supported by the Natural Science Foundation of Shanghai,No.24ZR1459300(to Xiao-Ting Liang);and the Pyramid Talent Project,No.YQ677(to Yue Ding).; This article discusses the study by Xiao et al,which investigated the therapeutic efficacy of serum-free cultured human umbilical cord mesenchymal stem cells(NhUCMSCs)in a mouse model of knee osteoarthritis.The result...; 关键词：Mesenchymal stem cells Serum-free culture OSTEOARTHRITIS Cartilage repair Regenerative medicine

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

OSTEOARTHRITIS

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

OSTEOARTHRITIS

检索结果分析

下载全文

用户登录

高级检索检索式检索