云南高校图书馆联盟文献共享服务平台- OSTEOARTHRITIS

OSTEOARTHRITIS: 作品数：669被引量：2304H指数：20; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：吴岩徐小洁欧阳宏伟冀全博夏青青更多>>; 相关机构：中南大学复旦大学上海交通大学附属第六人民医院军事医学科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划广东省自然科学基金更多>>

Optimizing bone marrow harvesting sites for enhanced mesenchymal stem cell yield and efficacy in knee osteoarthritis treatment: 《World Journal of Methodology》2025年第2期92-107,共16页Arulkumar Nallakumarasamy Sandeep Shrivastava Ravi Velamoor Rangarajan Naveen Jeyaraman Avinash Gandi Devadas Swaminathan Ramasubramanian Madhan Jeyaraman; Knee osteoarthritis(OA)is a debilitating condition with limited long-term treatment options.The therapeutic potential of mesenchymal stem cells(MSCs),particularly those derived from bone marrow aspirate concentrate,ha...; 关键词：KNEE OSTEOARTHRITIS Mesenchymal stem cells Bone marrow harvest Regenerative medicine

AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration: 《中国组织工程研究》2025年第17期3537-3547,共11页Yu Yangyi Song Zhuoyue Lian Qiang Ding Kang Li Guangheng; 国家自然科学基金面上项目(81472136),项目负责人:李广恒。; BACKGROUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent years.However,given the complexity of osteoarthritis pathogenesis,single gene ma...; 关键词：OSTEOARTHRITIS adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes.

Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis: 《Genes & Diseases》2025年第2期383-397,共15页Changyuan Huangg Bin Zeng Bo Zhou Guanming Chen Qi Zhang Wenhong Hou Guozhi Xiao Li Duan Ni Hong Wenfei Jin; supported by the National Key R&D Program of China (No.2021YFF1200900);National Natural Science Foundation of China (No.32170646,8197211);Guangdong Basic and Applied Basic Research Foundation (China) (No.2023A1515011908 to N.H.);Key-Area Research and Development Program of Guangdong Province,China (No.2023B1111020006);International Science and Technology CooperationnProgramnofGuangdong,China (No.2021A0505030011);Shenzhen Innovation Committee of Science and Technology (Guangdong,China) (No.JCYJ20220818100401003);Shenzhen Science and Technology Program (Guangdong,China) (No.SGDX20201103095800003,GJHZ20200731095606019,JCYJ20220818100401003);Shenzhen High-level Hospital Construction Fund (Guangdong,China) (No.1801004).; Chondrocyte is considered the only cell type in cartilage.However,the cell hetero-geneity of chondrocytes in human articular cartilage is still not well defined,which hinders our understanding of the pathogenesis of o...; 关键词：Cell heterogeneity Chondrocyte apoptosis Chondrocyte differentiation Chondrocyte fibrosis OSTEOARTHRITIS Single-cell RNA-seq

Strontium–Alix interaction enhances exosomal miRNA selectively loading in synovial MSCs for temporomandibular joint osteoarthritis treatment: 《International Journal of Oral Science》2025年第1期66-81,共16页Wenxiu Yuan Jiaqi Liu Zhenzhen Zhang Chengxinyue Ye Xueman Zhou Yating Yi Yange Wu Yijun Li Qinlanhui Zhang Xin Xiong Hengyi Xiao Jin Liu Jun Wang; supported by National Natural Science Foundation of China(Nos.82271019,82472149,82471024);Sichuan Science and Technology Program(No.24ZDYF0099);Research and Develop Program,West China Hospital of Stomatology Sichuan University(RD-03-202101)to J.W.; The ambiguity of etiology makes temporomandibular joint osteoarthritis(TMJOA)“difficult-to-treat”.Emerging evidence underscores the therapeutic promise of exosomes in osteoarthritis management.Nonetheless,challenges...; 关键词：OSTEOARTHRITIS ELEVATED LOADING

Efficacy equivalence but hidden hurdles:Can serum-free human umbilical cord mesenchymal stem cells translate to clinically superior osteoarthritis therapy: 《World Journal of Stem Cells》2025年第3期144-146,共3页Fang Lin Ke-Xin Ma Yue Ding Xiao-Ting Liang; Supported by the Natural Science Foundation of Shanghai,No.24ZR1459300(to Xiao-Ting Liang);and the Pyramid Talent Project,No.YQ677(to Yue Ding).; This article discusses the study by Xiao et al,which investigated the therapeutic efficacy of serum-free cultured human umbilical cord mesenchymal stem cells(NhUCMSCs)in a mouse model of knee osteoarthritis.The result...; 关键词：Mesenchymal stem cells Serum-free culture OSTEOARTHRITIS Cartilage repair Regenerative medicine

Effects of different acupuncture and moxibustion methods on knee joint cartilage morphology,serum inflammatory factors,and intestinal flora in rats with knee osteoarthritis: 《Journal of Acupuncture and Tuina Science》2025年第1期22-35,共14页DONG Qi JIA Yejuan QIN Lingling ZHANG Xiaoqin XU Jing LI Xiaofeng; 国家自然科学基金资助项目,No.82004449;河北省中医药管理局中医药类科研计划项目,No.2020133。; Objective:To compare the effects of manual acupuncture(MA),electroacupuncture(EA),and moxibustion on knee joint cartilage morphology,serum inflammatory factors interleukin(IL)-6 and IL-10,matrix metalloproteinase 13(M...; 关键词：Acupuncture Therapy Electroacupuncture Therapy Moxibustion Therapy Osteoarthritis Knee INTERLEUKINS Gastrointestinal Microbiome RATS

Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling: 《Genes & Diseases》2025年第1期250-265,共16页Daofu Zeng Muhammad Umar Zhenglin Zhu Haobo Pan William WLu Guozhi Xiao Yan Chen Liping Tong Di Chen; supported by National Key Research and Development Program of China(No.2021YFB3800800 to D.C.and L.T);the National Natural Science Foundation of China(No.82030067,82250710174,82161160342,82060406,82360429 and 82172397 to D.C.and L.T.and Y.C.);the Hong Kong RGC(China)(No.HKU-17101821 to W.W.L and D.C.);Shenzhen Science and Technology Program(Guangdong,China)(No.JSGGKQTD20210831174330015 to H.P.and D.C.);Natural Science Foundation of Guangxi(No.2022JJA141126 to Y.C.).; Osteoarthritis (OA) is a debilitating chronic joint disease affecting large populations of patients, especially the elderly. The pathological mechanisms of OA are currently unknown. Multiple risk factors are involved ...; 关键词：Β-CATENIN AMPK OSTEOARTHRITIS RUNX2 Signaling pathway

4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain: 《Chinese Journal of Traumatology》2025年第1期50-61,共12页Yu-Zhen Tang Wan Chen Bao-Yun Xu Gang He Xiu-Cheng Fan Kang-Lai Tang; supported by the Foundation of Chongqing Talents(grant no.CQYC2021059825).; Purpose:To investigate the pathological changes of the synovium in mice with post-traumatic osteoarthritis(PTOA)treated with 4-octyl itaconate(4-OI)and evaluate the therapeutic effects of 4-OI.Methods:In the phenotypi...; 关键词：4-Octyl itaconate SYNOVITIS Post-traumaticosteoarthritis PAIN

Corrigendum to“Ultrasound augmenting injectable chemotaxis hydrogel for articular cartilage repair in osteoarthritis”[Chinese Chemical Letters 32(2021)1759-1764]: 《Chinese Chemical Letters》2025年第2期563-565,共3页

Efficacy of acupuncture plus Tuina in agriculturists with knee osteoarthrosis in Phayao,Thailand:a randomized controlled trial: 《Journal of Acupuncture and Tuina Science》2025年第1期82-88,共7页Poonyaphat SIRITEERATHITIKUL Monticha KUNYALUE Yaowasak YAOWAPANKUL Punyisa PUDPONG Namngern CHANTARAMANEE Sasivimol BOOTSIKEAW Taweewun SRISOOKKUM; registered in the Thai Clinical Trials Registry(No.TCTR20221129004);approved by the Institutional Review Board of the University of Phayao(No.1.2/024/65)。; Objective:To study the efficacy of acupuncture combined with Tuina(Chinese therapeutic massage)compared to acupuncture alone and sham acupuncture in aspects of symptom control and mobility functions in farmers sufferi...; 关键词：ACUPUNCTURE TUINA MASSAGE Alternative Medicine Osteoarthritis Knee Randomized Controlled Trial

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