SENESCENCE

作品数：438被引量：1476H指数：16
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相关领域：医药卫生生物学更多>>
相关作者：彭长连林桂珠阳成伟朱玉贤王大勇更多>>
相关机构：北京大学中国科学院华南农业大学内蒙古农业大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>
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The miR-6779/XIAP axis alleviates IL-1β-induced chondrocyte senescence and extracellular matrix loss in osteoarthritis
《Animal Models and Experimental Medicine》2025年第4期662-673,共12页Zongchao Li Aonan Dai Xiaoxiang Fang Kexing Tang Kun Chen Peng Gao Jingyue Su Xin Chen Shengwu Yang Zhenhan Deng Liangjun Li 
Natural Science Foundation of Changsha city,China,Grant/Award Number:kq2403166;Hunan Provincial Clinical Medical Technology Innovation Guiding Project,Grant/Award Number:2020SK53307;Basic Public Welfare Research projects of Wenzhou Science and Technology Bureau,Grant/Award Number:Y20240087;Natural Science Foundation of Hunan Province,Grant/Award Number:2020JJ8043;Start-up Funding for Talented Scientific Research of the First Affiliated Hospital of Wenzhou Medical University,Grant/Award Number:2023QD026;Key Project of Hunan Provincial Health Commission,Grant/Award Number:20201902 and C2019133;National Natural Science Foundation of China,Grant/Award Number:82472495。
Background:Osteoarthritis(OA)is a long-term degenerative joint disease worsen-ing over time.Aging and chondrocyte senescence contribute to OA progression.MicroRNAs have been confirmed to regulate different cellular pr...
关键词：CHONDROCYTE miR-6779 OSTEOARTHRITIS SENESCENCE X-linked inhibitor of apoptosis protein 
HuLBD1 Promotes Flavonoid Biosynthesis Involved in Senescence of Hylocereus undatus by Negatively Regulating HuCHS
《Phyton-International Journal of Experimental Botany》2025年第3期825-842,共18页Xinxin Chen Fuxin Li Jingyu Jia Yajing Tian Xin Li 
supported by the National Key Research and Development Program of China(2017YFC1600802);Henan Provincial Science and Technology Research Project,China(No.232102110134);the National and Local Joint Engineering Laboratory of High Efficiency and Superior-Quality Cultivation and Fruit Deep Processing Technology of Characteristic Fruit Trees in South Xinjiang of China(No.FE202303).
In plants, transcription factor (TF) family LATERAL ORGAN BOUNDARIES DOMAIN (LBD) has been identified to be involved in the ripening and senescence processes of fruits. However, the function of LBD in Hylocereus undat...
关键词：HuLBD1 Hylocereus undatus flavonoid biosynthesis VIGS TRANSCRIPTOMICS 
Characterization of hepatic pathology during azoxymethane-induced acute liver failure
《World Journal of Gastroenterology》2025年第12期136-149,共14页Shadikchhya Maya Bhattarai Ashwin Jhawer Gabriel Frampton Eleonora Troyanovskaya Sharon DeMorrow Matthew McMillin 
Supported by The Department of Veterans Affairs Biomedical Laboratory Research&Development Service Award,No.BX003486(to McMillin M);National Institutes of Health Awards,No.R01DK112803 and No.R01DK135995(to DeMorrow S).
BACKGROUND Acute liver failure(ALF)is a loss of liver function due to a severe hepatic insult.Studies utilizing the azoxymethane(AOM)mouse model of ALF,which also generates hepatic encephalopathy,have primarily focuse...
关键词：Acute liver failure AZOXYMETHANE APOPTOSIS NECROSIS SENESCENCE 
NUMB endocytic adaptor protein(NUMB)mediates the anti-hepatic fibrosis effect of artesunate(ART)by inducing senescence in hepatic stellate cells(HSCs)
《Chinese Journal of Natural Medicines》2025年第3期322-333,共12页Yangling Qiu Yujia Li Mengran Li Yingqian Wang Min Shen Jiangjuan Shao Feng Zhang Xuefen Xu Feixia Wang Zili Zhang Shizhong Zheng 
supported by the National Natural Science Foundation of China(Nos.82474164,82374124,82073914,82173874,82274185,82305046 and 82304902);the Natural Science Foundation of Jiangsu Province(Nos.BK20230458 and BK20220467);the General Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.23KJB310017);Young Elite Scientists Sponsorship Program by CACM(No.2022-QNRC2-B15).
Developing and identifying effective medications and targets for treating hepatic fibrosis is an urgent priority.Our previous research demonstrated the efficacy of artesunate(ART)in alleviating liver fibrosis by elimi...
关键词：Hepatic stellate cells NUMB endocytic adaptor protein SENESCENCE ARTESUNATE UBIQUITYLATION Liver fibrosis 
Mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration
《Neural Regeneration Research》2025年第3期805-807,共3页JoséM.Izquierdo 
supported by the Ministry of Science and Innovation and the Spanish Research Agency through FEDER funds (PID2021-1261520B-100) (MICINN/AEI/FEDER, EU);CBM receives an institutional grant from the Fundación Ramón Areces, Spain。
The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre...
关键词：LATIN POTENTIAL lasting 
Identification of ferroptosis/autophagy-related genes and potential underlying mechanisms involved in the effect of BMSC senescence on the osteogenic differentiation of aging BMSCs
《Genes & Diseases》2025年第1期130-133,共4页Kai Chen Huaqiang Tao Haixiang Xiao Miao Chu Pengfei Zhu Shujun Lv Lixin Huang Dechun Geng 
supported by the National Natural Science Foundation of China(No.82072425);the Natural Science Foundation of Jiangsu Province,China(No.BK20220059);the Jiangsu Medical Research Project(China)(No.ZD2022021)。
Bone mesenchymal stem cells(BMSCs)are stem cells located in the bone marrow matrix that have a variety of differentiation potentials and biological functions.They play an important role in bone regenerative medicine.T...
关键词：DEGENERATION HOMEOSTASIS AGING 
In situ transcriptomic analysis of spermatocytes in non-obstructive azoospermia reveals senescence-like states in arrested spermatocytes
《Genes & Diseases》2025年第1期29-32,共4页Zhongqin Wu Xiaolong Wu Zeqian Xu Yixin Liu Ziyi Zhu Xinhui Li Daniel M. Czajkowsky Fei Sun Yan Guo Zhifeng Shao 
supported by the National Natural Science Foundation of China(No.81972909,31971151);the National Key Research and Development Program of China(No.2021YFC2700200);the Bio-ID Center at SJTU,and the K.C.Wong Education Foundation(H.K.).
Germ cell arrest is one kind of important disease in nonobstructive azoospermia(NOA)including spermatogonia arrest,spermatocyte arrest,and round spermatid arrest.1 There is an urgent need to explore the molecular mech...
关键词：OBSTRUCTIVE AZOOSPERMIA ARREST 
Nicotinamide adenine dinucleotide rejuvenates septic bone marrow mesenchymal stem cells
《World Journal of Stem Cells》2025年第2期53-67,共15页Xin Xia Kun Zhou Lin-Ying An Min Zhao Bin-Le Tian Jin-Yan Zhao Zhi-Gang Zhou Yin Tong 
Shanghai Natural Science Foundation,No.21ZR1452300;the Clinical Research Innovation Plan of Shanghai General Hospital,No.CCTR-2022B04.
BACKGROUND Sepsis is a severe illness characterized by systemic and multiorgan reactive responses and damage.However,the impact of sepsis on the bone marrow,particularly on bone marrow mesenchymal stem cells(BMSCs),is...
关键词：SEPSIS Bone mesenchymal stem cells Hematopoietic stem cells SENESCENCE Nicotinamide adenine dinucleotide 
Extracellular vesicles deliver thioredoxin to rescue stem cells from senescence and intervertebral disc degeneration via a feed-forward circuit of the NRF2/AP-1 composite pathway
《Acta Pharmaceutica Sinica B》2025年第2期1007-1022,共16页Xuanzuo Chen Sheng Liu Huiwen Wang Yiran Liu Yan Xiao Kanglu Li Feifei Ni Wei Wu Hui Lin Xiangcheng Qing Feifei Pu Baichuan Wang Zengwu Shao Yizhong Peng 
supported by the National Natural Science Foundation of China(82202764 and 81974352);the China Postdoctoral Science Foundation(2021M701331);Natural Science Foundation of Hubei Province(2020CFB778,China);the Scientific Research Training Program for Young Talents from Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China.
Intervertebral disc degeneration(IDD)is largely attributed to impaired endogenous repair.Nucleus pulposus-derived stem cells(NPSCs)senescence leads to endogenous repair failure.Small extracellular vesicles/exosomes de...
关键词：TXN NRF2 AP-1 Exosomes SENESCENCE Intervertebral disc degeneration NPSCs ESCRT 
Author Correction:Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells
《Acta Pharmacologica Sinica》2025年第2期512-514,共3页Yin-da Qiu Qi Yan Yi Wang Yan-fei Ye Yan Wang Meng-ying Wang Pei-pei Wang Shu-yuan Zhang Da-long Wang Hao Yan Jing Ruan Yun-jie Zhao Le-hao Huang Namki Cho Kun Wang Xiao-hui Zheng Zhi-guo Liu 
Correction to:Acta Pharmacologica Sinica(2024)45:1276-1286 https://doi.org/10.1038/s41401-024-01243-6;Article published online 4 March 2024 Substituents of active compounds FKB04 are incorrectly plotted in Figure 2a a...
关键词：FIGURE SHORTENING supporting 
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