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DEGENERATION: 作品数：531被引量：1042H指数：13; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：施杞梁倩倩王拥军侯炜崔学军更多>>; 相关机构：上海中医药大学复旦大学青岛大学华中科技大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划中国博士后科学基金更多>>

P2X7 receptors and multiple sclerosis: A potential biomarker and therapeutic target?: 《Neural Regeneration Research》2026年第1期318-319,共2页Cristina Agliardi Franca Rosa Guerini Mario Clerici; supported by Italian Ministry of Health Ricerca Corrente [RC 2023] and RF-2016-02361294;supported by#NEXTGENERATIONEU (NGEU);funded by the Ministry of University and Research (MUR);National Recovery and Resilience Plan (NRRP);project MNESYS (PE0000006)–A Multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022)(to FRG);partially supported by a grant from Fondazione Romeo ed Enrica Invernizzi (to FRG)。; Multiple sclerosis(MS) is a chronic, autoimmune and neuroinflammatory disease of the central nervous system(CNS) with a neurodegenerative component, characterized by demyelination and degeneration of nerve fibers. It ...; 关键词：SCLEROSIS DEGENERATION THERAPEUTIC

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss被引量：1: 《Neural Regeneration Research》2025年第10期3025-3039,共15页Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin; supported by the National Natural Science Foundation of China,Nos.81800919(to YX),82171140(to PW);the International Cooperation and Exchange of the National Natural Science Foundation of China,Nos.82020108008(to HS),81720108010(to SY).; Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as ...; 关键词：DEGENERATION hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome OTOTOXICITY pyroptosis sensorineural hearing loss spiral ganglion neuron

Mechanisms behind elevated serum levels of plasminogen activator inhibitor-1 in frontotemporal lobar degeneration: 《Neural Regeneration Research》2025年第8期2317-2318,共2页Francesco Angelucci Jakub Hort; funded by the project National Institute for Neurological Research(Programme EXCELES,ID Project No.LX22NPO5107);TEAMING:857560(EU);CZ.02.1.01/0.0/0.0/17_043/0009632(CZ)(to FA and JH)。; Frontotemporal lobar degeneration(FTLD)is a form of progressive dementia characterized by degeneration of the frontal and temporal lobes of the brain.This pathology involves a series of cognitive,behavioral,and neurol...; 关键词：DEGENERATION ELEVATED PATHOLOGY

Role of glutathione transferase in phase separation of FUS and TAF15 in neurons: 《Neural Regeneration Research》2025年第7期1999-2000,共2页Kiyoung Kim; supported by the BK21 FOUR(Fostering Outstanding Universities for Research)and the Basic Science Research Program through the National Research Foundation of Korea(NRF),funded by the Ministry of Education(MOE)and the Ministry of Science and ICT(MSIT)(NRF-2022R1A2C1004204,RS-2023-00219563,2023-DD-UP-0007);by the Soonchunhyang University Research Fund(to KK)。; Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder characterized by the degeneration of motor neurons in the brain and spinal cord,leading to muscle weakness,paralysis,and ultimately death(C...; 关键词：DEGENERATION FUS AGGREGATION

Dendritic spine degeneration:a primary mechanism in the aging process: 《Neural Regeneration Research》2025年第6期1696-1698,共3页Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith Vázquez-Hernández Hiram Tendilla-Beltrán; funded by CONAHCYT grant(252808)to GF;CONAHCYT’s“Estancias Posdoctorales por México”program(662350)to HTB。; Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a w...; 关键词：AGING PROCESS STRESS

ADAM8 inactivation modulates cellular component assembly gene expression in the mouse intervertebral disc: 《Genes & Diseases》2025年第3期54-56,共3页Ken Chen Zuozhen Tian Motomi EnomotoIwamoto Yejia Zhang; Dear Editor ADAM8(ADAM metallopeptidase domain 8,aka MS2/CD156/CD156a)is a membrane-anchored proteinase.ADAM8 and its proteolytic product,fibronectin fragments,are elevated in degenerative human intervertebral discs(I...; 关键词：degenerative human intervertebral discs ivds degenerative disc diseasea Intervertebral Disc fibronectin fragments DEGENERATION Adam Fibronectin Fragments Gene Expression

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia: 《Neural Regeneration Research》2025年第5期1397-1398,共2页Zhenyu Chen Xue-Jun Li; supported by the NIH grant(RO1 NS118066);the Blazer Foundation(to XJL)。; Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower extre...; 关键词：DEGENERATION DISEASES HEREDITARY

Progressive noradrenergic degeneration and motor cortical dysfunction in Parkinson’s disease: 《Acta Pharmacologica Sinica》2025年第4期829-835,共7页Wei Zhou Hong-Yuan Chu; funded in part by Aligning Science Across Parkinson’s(ASAP-020572);NIH grants(R01NS121371 and R21NS135545);Department of Defense Congressionally Directed Medical Research Programs(W81XWH-21-1-0943);Parkinson’s Foundation(PF-IMP-1045313).; The locus coeruleus norepinephrine(LC-NE)system plays an important role in regulating brain function,and its neuronal loss has been well-documented in Parkinson’s disease(PD).The LC-NE neurodegeneration is believed t...; 关键词：locus coeruleus NOREPINEPHRINE DOPAMINE parkinson’s disease motor cortex cognition

Aging-related inflammatory and metabolic disorder in the novel mutation of colony-stimulating factor-1 receptor(csf1r)^(P853T/+)in CsF1R-microglial encephalopathy: 《Genes & Diseases》2025年第2期45-47,共3页Xiaohong Wang Yanli Wang Tianlin Jiang Jiwei Jiang Linlin Wang Shiyi Yang Mengfan Sun Yuan Zhang Ziyan Jia Wenyi Li Qiwei Ren Cuicui Zhang Jianjian Liu Yinwei Zhu Min Zhao Shirui Jiang Huiying Zhang Jinglong Chen Jun Xu; supported by the National Natural Science Foundation of China (No.82071187,81870821,81501135,and 81471215);the National Key Research and Development Program of China (No.2021YFC2500100,2021YFC2500103);the Beijing Youth Talent Team Support Program (China) (No.2018000021223TD08);Science and Technology Program of Guangzhou (China) (No.202201020343).; CSF1R-microglial encephalopathy(CME)is a rare dementia with rapid development of cognitive impairment.The main clinical features of CME are progressive cognitive impairment,motor dysfunction,and neuropsychiatric sympt...; 关键词：ENCEPHALOPATHY DEGENERATION IMPAIRMENT

Progress on Physiological Mechanisms of Rice Spikelet Degeneration at Different Panicle Positions Caused by Abiotic Stress: 《Rice science》2025年第2期193-202,共10页WANG Jingqing WANG Yaliang CHEN Yulin CHEN Huizhe XIANG Jing ZHANG Yikai WANG Zhigang ZHANG Yuping; funded by the National Natural Science Foundation of China(Grant No.32201896);the Zhejiang Province Key Research and Development Plan Project,China(Grant No.2022C02034);the National Modern Agricultural Industrial Technology System Construction Project,China(Grant No.CARS-01-21).; Rice yield is heavily reliant on the number of spikelets per panicle,a factor determined by the processes of spikelet differentiation and degeneration.In rice cultivars with large panicles,spikelet degeneration negate...; 关键词：Oryza sativa spikelet degeneration characteristic physiological mechanism cultivation alleviation approach

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