IMPAIRMENT

作品数：529被引量：1300H指数：17
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Aptamers as new promising entities for therapeutics:our experience from the neurological diseases
《Neural Regeneration Research》2025年第12期3523-3524,共2页Macarena Hernández-Jiménez Fernando de Castro 
Based on data from Global Burden of Disease,Injuries,and Risk Factors(2024),disorders of the central nervous system(CNS)are an important cause of death or long-term disability,representing the top-ranked contributor t...
关键词：DISEASES CONGENITAL IMPAIRMENT 
Aging-related inflammatory and metabolic disorder in the novel mutation of colony-stimulating factor-1 receptor(csf1r)^(P853T/+)in CsF1R-microglial encephalopathy
《Genes & Diseases》2025年第2期45-47,共3页Xiaohong Wang Yanli Wang Tianlin Jiang Jiwei Jiang Linlin Wang Shiyi Yang Mengfan Sun Yuan Zhang Ziyan Jia Wenyi Li Qiwei Ren Cuicui Zhang Jianjian Liu Yinwei Zhu Min Zhao Shirui Jiang Huiying Zhang Jinglong Chen Jun Xu 
supported by the National Natural Science Foundation of China (No.82071187,81870821,81501135,and 81471215);the National Key Research and Development Program of China (No.2021YFC2500100,2021YFC2500103);the Beijing Youth Talent Team Support Program (China) (No.2018000021223TD08);Science and Technology Program of Guangzhou (China) (No.202201020343).
CSF1R-microglial encephalopathy(CME)is a rare dementia with rapid development of cognitive impairment.The main clinical features of CME are progressive cognitive impairment,motor dysfunction,and neuropsychiatric sympt...
关键词：ENCEPHALOPATHY DEGENERATION IMPAIRMENT 
Continuum of glucose and bone metabolism impairment across autonomous cortisol secretion: A cross-sectional study
《World Journal of Diabetes》2025年第3期134-145,共12页Min-Min Han Xiao-Ming Cao Zi-Ang Liu Yi Zhang Yun-Feng Liu 
Supported by National Natural Science Foundation of China(General Program),No.82073909;Four‘Batches’Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province,No.2023XM022;The Shanxi Provincial Central Leading Local Science and Technology Development Fund Project,No.YDZJSX2022A059 and No.YDZJSX20231A059。
BACKGROUND Autonomous cortisol secretion(ACS)is linked to a higher prevalence of metabolic abnormalities and an increased risk of major adverse cardiovascular events.AIM To evaluate glucose and bone metabolism in pati...
关键词：Continuous glucose monitoring system Glucose variability Time in range Autonomous cortisol secretion Bone mineral content Bone mineral density Bone area 
Glabridin and gymnemic acid alleviates choroid structural change and choriocapillaris impairment in diabetic rat’s eyes
《World Journal of Diabetes》2025年第3期187-202,共16页Udomlak Matsathit Manaras Komolkriengkrai Wipapan Khimmaktong 
Supported by the Prince of Songkla University Research Fund,No.SCI6302040S。
BACKGROUND Small blood vessels in the eyes are more susceptible to injury,which can lead to complications.However,since diabetic retinopathy is often a serious clinical condition,most of this study focuses on the vasc...
关键词：Diabetes CHOROID Gymnemic acid GLABRIDIN Vascular endothelial growth factor Cluster of differentiation 31 CHORIOCAPILLARIS 
Compound heterozygous mutation of AFG3L2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Ca2+overload
《Science China(Life Sciences)》2025年第2期484-501,共18页Hongyu Li Qingwen Ma Yan Xue Linlin Cai Liwen Bao Lei Hong Yitao Zeng Shu-Zhen Huang Richard H.Finnell Fanyi Zeng 
supported by the National Key Research and Development Program of China(2019YFA0801402);the National Natural Science Foundation of China(82271890);the Shanghai Key Clinical Specialty Project(shslczdzk05705);the Shanghai Top Priority Key Discipline Project(2017ZZ02019);Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20212200);the Macao Science and Technology Development Fund(FDCT)(0092/2022/A2,003/2022/ALC)。
Autosomal recessive spinocerebellar ataxias(SCARs)are one of the most common neurodegenerative diseases characterized by progressive ataxia.Although SCARs are known to be caused by mutations in multiple genes,there ar...
关键词：AFG3L2 gene autosomal recessive spinocerebellar ataxia mitochondrial impairment Ca2+overload 
The Impairment Attention Capture by Topological Change in Children With Autism Spectrum Disorder
《生物化学与生物物理进展》2025年第1期223-232,共10页XU Hui-Lin XI Huan-Jun DUAN Tao LI Jing LI Dan-Dan WANG Kai ZHU Chun-Yan 
安徽省高校协同创新项目(GXXT-2021-003);国家自然科学基金(91432301)资助。
Objective Autism spectrum disorder(ASD)is a neurodevelopmental condition characterized by difficulties with communication and social interaction,restricted and repetitive behaviors.Previous studies have indicated that...
关键词：ATTENTION autism spectrum disorder perceptual object topological perception 
Minimally Invasive Transthoracic Intramyocardial Cellular Transplantation Under Echocardiographic Guidance for Myocardial Impairment
《Cardiology Discovery》2024年第4期260-273,共14页Sulei Li Bo Tao Junsong Liu Dongyue Liu Yujia Wang Jibin Zhang Lei Tian Baixuan Xu Yan Fang Yabin Wang Xin Lou Jinming Zhang Feng Lan Feng Cao 
funded by the National Key Research and Development Projects of China(2022YFA1104500,2022YFC3602400);National Nature Science Foundation of China(91939303,92249301,U22A6008);Youth Independent Innovation Project of Chinese People's Liberation Army General Hospital(22QNFC043).
Objective:To explore the approach of minimally invasive transthoracic intramyocardial cellular transplantation under echocardiographic guidance to promote ischemic myocardial repair in a preclinical big-animal study.M...
关键词：Myocardial infarction Intramyocardial transplantation Stem cell therapy Echocardiography-guided 
Molecular biomarkers for vascular cognitive impairment and dementia:the current status and directions for the future被引量：1
《Neural Regeneration Research》2024年第12期2579-2580,共2页Satoshi Hosoki Perminder SSachdev 
supported by the Japan Society for the Promotion of Science Overseas Research Fellow,the fellowship of Astellas Foundation for Research on Metabolic Disorders and the Japanese Society of Neurology grants for overseas study“Young Researcher Overseas Training Program” (SH)and NHMRC CRE grant 2006765 (to PSS)。
Dementia is a syndrome with various underlying pathologies acting independently or in concert to cause cognitive dysfunction.The development of disease-specific treatments and targeted prevention strategies requires p...
关键词：PREVENTION DIAGNOSIS IMPAIRMENT 
Time-restricted feeding relieves high temperature-induced impairment on meat quality by activating the Nrf2/HO-1 pathway,modification of muscle fiber composition,and enriching the polyunsaturated fatty acids in pigs
《Stress Biology》2024年第1期205-220,共16页Zhaojian Li Yiting Wang Peng Yuan Yanli Zhu Ping Hu Tongxing Song Rui Liu Hao-Yu Liu Demin Cai 
supported by the Natural Science Foundation of Jiangsu Province(BK20220582);Jiangsu Funding Program for Excellent Postdoctoral Talent,the Jiangsu Agricultural Science And Technology Innovation Fund[CX(21)2014];Jiangsu Provincial Double-Innovation Team Program(JSSCTD202147);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
To assess the effects of a time-restricted feeding(TRF)regimen on meat quality of pigs exposed to high ambient temperature,a two-month feeding and heat treatment(HT)trial was conducted using a 2×2 factorial design.A ...
关键词：Meat quality Time-restricted feeding High ambient temperature Muscle fiber composition NRF2 Fatty acids composition 
Precise and efficient insertion of A673T mutation in APP gene using MSYM
《Genes & Diseases》2024年第6期65-68,共4页Qing Xia Zijie Liu Xinyu Yang Jiaying Xiao Xue Zhao Yu Zhao Feifei Zheng Fangliang Ge Ke Ye Lulu Liu Dayong Wang Xu Gao 
supported by the National Natural Science Foundation of China (No.81701078);the Natural Science Foundation of Heilongjiang Province of China (Outstanding Youth Foundation,No.YQ2022H003);China Postdoctoral Science Foundation (No.2016M600261,2018T110317);Heilongjiang Postdoctoral Financial Assistance (China) (No.LBH-Z15163);Heilongjiang Touyan Innovation Team Program (China).
Alzheimer's disease(AD)is a progressive neurodegenerative disorder causing memory loss,cognitive decline,language impairment,and disorientation,which impose an enormous burden on caregivers and the public health secto...
关键词：protective ALZHEIMER IMPAIRMENT 
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