云南高校图书馆联盟文献共享服务平台- IMPAIRMENT

IMPAIRMENT: 作品数：533被引量：1306H指数：17; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王宁宇柯亚容永豪吴含刘继红更多>>; 相关机构：南京医科大学哈尔滨医科大学中国科学院山西医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>

Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease: 《Neural Regeneration Research》2026年第2期569-576,共8页Qian Yue Shang Li Chon Lok Lei Huaibin Wan Zaijun Zhang Maggie Pui Man Hoi; supported by the National Natural Science Foundation of China,Nos.82404892(to QY),82061160374(to ZZ);the Science and Technology Development Fund,Macao Special Administrative Region,China,Nos.0023/2020/AFJ,0035/2020/AGJ;the University of Macao Research Grant,Nos.MYRG2022-00248-ICMS,MYRG-CRG2022-00010-ICMS(to MPMH);the Natural Science Foundation of Guangdong Province,No.2024A1515012818(to ZZ);the Fundamental Research Funds for the Central Universities,No.21623114(to ZZ).; Drug development for Alzheimer’s disease is extremely challenging,as demonstrated by the repeated failures of amyloid-β-targeted therapeutics and the controversies surrounding the amyloid-βcascade hypothesis.More r...; 关键词：Alzheimer’s disease brain microvessel endothelial cells transcriptomic heterogeneity endothelial activation blood-brain barrier impairment neurovascular cell-cell communication

Aptamers as new promising entities for therapeutics:our experience from the neurological diseases: 《Neural Regeneration Research》2025年第12期3523-3524,共2页Macarena Hernández-Jiménez Fernando de Castro; Based on data from Global Burden of Disease,Injuries,and Risk Factors(2024),disorders of the central nervous system(CNS)are an important cause of death or long-term disability,representing the top-ranked contributor t...; 关键词：DISEASES CONGENITAL IMPAIRMENT

Aging-related inflammatory and metabolic disorder in the novel mutation of colony-stimulating factor-1 receptor(csf1r)^(P853T/+)in CsF1R-microglial encephalopathy: 《Genes & Diseases》2025年第2期45-47,共3页Xiaohong Wang Yanli Wang Tianlin Jiang Jiwei Jiang Linlin Wang Shiyi Yang Mengfan Sun Yuan Zhang Ziyan Jia Wenyi Li Qiwei Ren Cuicui Zhang Jianjian Liu Yinwei Zhu Min Zhao Shirui Jiang Huiying Zhang Jinglong Chen Jun Xu; supported by the National Natural Science Foundation of China (No.82071187,81870821,81501135,and 81471215);the National Key Research and Development Program of China (No.2021YFC2500100,2021YFC2500103);the Beijing Youth Talent Team Support Program (China) (No.2018000021223TD08);Science and Technology Program of Guangzhou (China) (No.202201020343).; CSF1R-microglial encephalopathy(CME)is a rare dementia with rapid development of cognitive impairment.The main clinical features of CME are progressive cognitive impairment,motor dysfunction,and neuropsychiatric sympt...; 关键词：ENCEPHALOPATHY DEGENERATION IMPAIRMENT

Gut microbiota's role in high-altitude cognitive impairment:the therapeutic potential of Clostridium sp.supplementation: 《Science China(Life Sciences)》2025年第4期1132-1148,共17页Wei Zhou Yongqiang Zhou Shikun Zhang Bin Li Zhong Li Zhijie Bai Dezhi Sun Chaoji Huangfu Ningning Wang Tiantian Xia Congshu Huang Lina Guan Xi Yang Yangyi Hu Pengfei Zhang Pan Shen Rui Wang Zhexin Ni Yue Gao; supported by the Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202207,Y.G.);the Young Elite Scientists Sponsorship Program by CAST(2021-QNRC1-03,W.Z.)。; Prolonged exposure to high-altitude environments may increase the risk of cognitive decline in young migrants.Recent studies suggest that hypobaric hypoxia-induced alterations in gut microbial composition could partly...; 关键词：HIGH-ALTITUDE cognition impairment microbial mechanisms Clostridium sp. L-VALINE

Continuum of glucose and bone metabolism impairment across autonomous cortisol secretion: A cross-sectional study: 《World Journal of Diabetes》2025年第3期134-145,共12页Min-Min Han Xiao-Ming Cao Zi-Ang Liu Yi Zhang Yun-Feng Liu; Supported by National Natural Science Foundation of China(General Program),No.82073909;Four‘Batches’Innovation Project of Invigorating Medical through Science and Technology of Shanxi Province,No.2023XM022;The Shanxi Provincial Central Leading Local Science and Technology Development Fund Project,No.YDZJSX2022A059 and No.YDZJSX20231A059。; BACKGROUND Autonomous cortisol secretion(ACS)is linked to a higher prevalence of metabolic abnormalities and an increased risk of major adverse cardiovascular events.AIM To evaluate glucose and bone metabolism in pati...; 关键词：Continuous glucose monitoring system Glucose variability Time in range Autonomous cortisol secretion Bone mineral content Bone mineral density Bone area

Glabridin and gymnemic acid alleviates choroid structural change and choriocapillaris impairment in diabetic rat’s eyes: 《World Journal of Diabetes》2025年第3期187-202,共16页Udomlak Matsathit Manaras Komolkriengkrai Wipapan Khimmaktong; Supported by the Prince of Songkla University Research Fund,No.SCI6302040S。; BACKGROUND Small blood vessels in the eyes are more susceptible to injury,which can lead to complications.However,since diabetic retinopathy is often a serious clinical condition,most of this study focuses on the vasc...; 关键词：Diabetes CHOROID Gymnemic acid GLABRIDIN Vascular endothelial growth factor Cluster of differentiation 31 CHORIOCAPILLARIS

Compound heterozygous mutation of AFG3L2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Ca2+overload: 《Science China(Life Sciences)》2025年第2期484-501,共18页Hongyu Li Qingwen Ma Yan Xue Linlin Cai Liwen Bao Lei Hong Yitao Zeng Shu-Zhen Huang Richard H.Finnell Fanyi Zeng; supported by the National Key Research and Development Program of China(2019YFA0801402);the National Natural Science Foundation of China(82271890);the Shanghai Key Clinical Specialty Project(shslczdzk05705);the Shanghai Top Priority Key Discipline Project(2017ZZ02019);Innovative Research Team of High-Level Local Universities in Shanghai(SHSMU-ZDCX20212200);the Macao Science and Technology Development Fund(FDCT)(0092/2022/A2,003/2022/ALC)。; Autosomal recessive spinocerebellar ataxias(SCARs)are one of the most common neurodegenerative diseases characterized by progressive ataxia.Although SCARs are known to be caused by mutations in multiple genes,there ar...; 关键词：AFG3L2 gene autosomal recessive spinocerebellar ataxia mitochondrial impairment Ca2+overload

The Impairment Attention Capture by Topological Change in Children With Autism Spectrum Disorder: 《生物化学与生物物理进展》2025年第1期223-232,共10页XU Hui-Lin XI Huan-Jun DUAN Tao LI Jing LI Dan-Dan WANG Kai ZHU Chun-Yan; 安徽省高校协同创新项目(GXXT-2021-003);国家自然科学基金(91432301)资助。; Objective Autism spectrum disorder(ASD)is a neurodevelopmental condition characterized by difficulties with communication and social interaction,restricted and repetitive behaviors.Previous studies have indicated that...; 关键词：ATTENTION autism spectrum disorder perceptual object topological perception

Minimally Invasive Transthoracic Intramyocardial Cellular Transplantation Under Echocardiographic Guidance for Myocardial Impairment: 《Cardiology Discovery》2024年第4期260-273,共14页Sulei Li Bo Tao Junsong Liu Dongyue Liu Yujia Wang Jibin Zhang Lei Tian Baixuan Xu Yan Fang Yabin Wang Xin Lou Jinming Zhang Feng Lan Feng Cao; funded by the National Key Research and Development Projects of China(2022YFA1104500,2022YFC3602400);National Nature Science Foundation of China(91939303,92249301,U22A6008);Youth Independent Innovation Project of Chinese People's Liberation Army General Hospital(22QNFC043).; Objective:To explore the approach of minimally invasive transthoracic intramyocardial cellular transplantation under echocardiographic guidance to promote ischemic myocardial repair in a preclinical big-animal study.M...; 关键词：Myocardial infarction Intramyocardial transplantation Stem cell therapy Echocardiography-guided

Molecular biomarkers for vascular cognitive impairment and dementia:the current status and directions for the future被引量：1: 《Neural Regeneration Research》2024年第12期2579-2580,共2页Satoshi Hosoki Perminder SSachdev; supported by the Japan Society for the Promotion of Science Overseas Research Fellow,the fellowship of Astellas Foundation for Research on Metabolic Disorders and the Japanese Society of Neurology grants for overseas study“Young Researcher Overseas Training Program” (SH)and NHMRC CRE grant 2006765 (to PSS)。; Dementia is a syndrome with various underlying pathologies acting independently or in concert to cause cognitive dysfunction.The development of disease-specific treatments and targeted prevention strategies requires p...; 关键词：PREVENTION DIAGNOSIS IMPAIRMENT

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