supported by the National Natural Science Foundation of China (No.82071187,81870821,81501135,and 81471215);the National Key Research and Development Program of China (No.2021YFC2500100,2021YFC2500103);the Beijing Youth Talent Team Support Program (China) (No.2018000021223TD08);Science and Technology Program of Guangzhou (China) (No.202201020343).
CSF1R-microglial encephalopathy(CME)is a rare dementia with rapid development of cognitive impairment.The main clinical features of CME are progressive cognitive impairment,motor dysfunction,and neuropsychiatric sympt...
BACKGROUND Sarcopaenia is associated with a two-fold higher mortality rate in patients with cirrhosis independent of liver disease severity.Few treatments for cirrhosis related sarcopaenia exist beyond optimal nutriti...
supported by grants from the general project of Nanjing Medical University Science and Technology Development Foundation (Grant No.NMUB20210112)。
Inflammation plays a crucial role in the initiation and progression of sepsis and induces alterations in brain neurotransmission, thereby contributing to the development of sepsis-associated encephalopathy(SAE).Parval...
Jiang et al explored the diagnostic capabilities of EncephalApp,a smartphone-based Stroop Test,in patients with nonalcoholic liver disease.The study included 160 patients with nonalcoholic cirrhosis and utilized the p...
supported by the Shenzhen Science and Technology Innovation Commission(JCYJ20200109110001818,JCYJ20220818095617038);Basic and Applied Basic Research Fund of Guangdong Province(2022A1515010609);the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions(2023SHIBS0003).
Selenium(Se)is an essential trace element of the utmost importance to human health.Its deficiency induces various disorders.Se species can be absorbed by organisms and metabolized to hydrogen selenide for the biosynth...
Background: Rare pathological conditions are frequently a diagnostic challenge in intensive care. Posterior-reversible encephalopathy syndrome (PRES) is a clinical and imaging diagnosis recently individualized. It occ...
This work was supported by Health Research Council of New Zealand(grants 17/601 and 22/559);the Auckland Medical Research Foundation,the Lottery Health Grants Board of New Zealand,the C.J.Martin Postdoctoral Fellowship and project grant from the National Health and Medical Research Council of Australia(APP1090890 and APP1164954);the Victorian Government’s Operational Infrastructure Support Program(to RG).
Mitigating preterm encephalopathy continues to be one of the greatest challenges in perinatal medicine.Preterm encephalopathy is associated with high mortality,serious morbidity,and significant socio-economic impacts ...
BACKGROUND Wernicke encephalopathy is a neurological disorder caused by thiamine deficiency,commonly seen in alcoholic populations but also involving other circumstances that may lead to thiamine deficiency.The recogn...
Youth Project of National Natural Science Foundation of China:the Mechanism Study of Shenfuhuang Formula on Cognitive Impairment and Synaptic Plasticity in Sepsis via IL-33/ST2 Pathway-mediated Microglial Polarization(No.82004292);Special Project of National Natural Science Foundation of China:Study on the Mechanism and Material Basis of Jinhua Qinggan Granules in Regulating the Cytokine Storm of Viral Pneumonia(No.82141202);The National Interdisciplinary Innovation Team of TCM under the State Administration of TCM(ZYYCXTD-D-202201);The Financial project of Beijing Municipal Health Commission:Study on Pharmacodynamic Mechanism of Traditional Chinese Medicine in Treating Viral Pneumonia。
Sepsis-associated encephalopathy(SAE)is a common manifestation of sepsis,ranging from mild confusion and delirium to severe cognitive impairment and deep coma.SAE is associated with higher mortality and long-term outc...
BACKGROUND The precise mechanism by which severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)impacts the central nervous system remains unclear,with manifestations spanning from mild symptoms(e.g.,olfactory an...