supported by a grant from Telethon Foundation(grant No.GGP20056 to SB);The generation of Pcdh19 floxed mouse model was funded by Cariplo Foundation(grant No.2014-0972 to SB)。
Mutations in the protocadherin-19(PCDH19)gene(Xq22.1)cause the X-linked syndrome known as developmental and epileptic encephalopathy 9(DEE9,OMIM#300088)(Dibbens et al.,2008).DEE9 is characterized by early-onset cluste...
supported by the National Institute of Mental Health (NIH/NIMH);the National Institute of Neurological Disorders and Stroke(NIH/NINDS):Grants#R21 MH132136 to FSN and R01 MH123700 and R01 NS040701 to MLD
There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons...
supported by National Health and Medical Research Council GNT1105374,GNT1137645,GNT2000766 and veski Innovation Fellowship(VIF23)to RP.
Nuclear factor Y is a ubiquitous heterotrimeric transcription factor complex conserved across eukaryotes that binds to CCAAT boxes,one of the most common motifs found in gene promoters and enhancers.Over the last 30 y...
supported by the Japan Society for the Promotion of Science KAKENHI(grant Nos.23K05678 to IM,19H05711 and 20H00466 to KS);the Joint Research Program of Institute for Molecular and Cellular Regulation,Gunma University(to KS)。
In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting t...
supports from the National Natural Science Foundation of China(82130112,U24A20789);Beijing Hospitals Authority Ascent Plan(DFL20190702);Youth Beijing Scholar(2022-051)。
Lonicera japonica(honeysuckle)is a traditional Chinese medicinal food,in which the main active ingredients are phenolic acids,polysaccharides,flavonoids,and volatile oils.They have various biological activities,includ...
Smith-Kingsmore syndrome(SKS)is a very rare dominantly inherited disorder caused by a gain-of-function mutation in MTOR(mechanistic target of rapamycin).1,2 It is typically characterized by megalencephaly,developmenta...
Supported by the Social Development Projects of Nantong,No.MS12019019,No.HS2022004 and No.MS2023083;the Medical Research Project of the Jiangsu Health Commission,No.Z2022058;the National Natural Science Foundation of China,No.32101027。
BACKGROUND Increased blood urea nitrogen(BUN)levels have been demonstrated to be associated with broader metabolic disturbances and the incidence of type 2 diabetes(T2D),potentially playing a role in the development o...
There is an error in the name of the cell line in the abstract of the published paper“MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons”published on pages 2698-2707,Issue 12,Volume 19 of Ne...
supported by the National Key Research and Development Program of China(No.2022YFC3204003);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(Wenqiang Zhang,No.2018058).
Particulate organic matter(POM)plays a crucial role in the organic composition of lakes;however,its characteristics remain poorly understood.This study aimed to characterize the structure and composition of POM in Lak...
Project supported by the National Natural Science Foundation of China(Grant Nos.12174048 and 12204128)。
A Wentzel-Kramers-Brillouin(WKB)method is introduced for obtaining a uniform asymptotic solution for underwater sound propagation at very low frequencies in deep ocean.The method utilizes a mode sum and employs the re...