ENDOSOMES

作品数：15被引量：26H指数：2
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相关领域：生物学更多>>
相关机构：浙江大学医学院附属第一医院厦门大学中国科学院更多>>
相关期刊：《Molecular Plant》《Cellular & Molecular Immunology》《Virologica Sinica》《Stress Biology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划福建省自然科学基金更多>>
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New aspects of a small GTPase RAB35 in brain development and function
《Neural Regeneration Research》2025年第7期1971-1980,共10页Ikuko Maejima Ken Sato 
supported by the Japan Society for the Promotion of Science KAKENHI(grant Nos.23K05678 to IM,19H05711 and 20H00466 to KS);the Joint Research Program of Institute for Molecular and Cellular Regulation,Gunma University(to KS)。
In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting t...
关键词：ENDOCYTOSIS ENDOSOMES hippocampal development neurodegenerative diseases RAB35 
Interplay of transport vesicles during plant-fungal pathogen interaction
《Stress Biology》2023年第1期377-386,共10页Yakubu Saddeeq Abubakar Idris Zubair Sadiq Aarti Aarti Zonghua Wang Wenhui Zheng 
supported by the National Natural Science Foundation of China(32122071,32272481,31772106);the Natural Science Foundation of Fujian Province(2021J06015).
Vesicle trafficking is an essential cellular process upon which many physiological processes of eukaryotic cells rely.It is usually the‘language’of communication among the components of the endomembrane system withi...
关键词：ENDOSOMES Extracellular vesicles Plant-pathogen interaction PHYTOPATHOGENS Vesicles trafficking 
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages被引量：2
《Cellular & Molecular Immunology》2022年第2期210-221,共12页Zhenfeng Wang Jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang 
supported by the National Natural Science Foundation of China(81788101,91942314);CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-1-021).
Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy.Here,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a po...
关键词：SARS-CoV-2 MICROPARTICLES Alveolar macrophages ENDOSOMES LYSOSOMES 
FgRab5 and FgRab7 are essential for endosomes biogenesis and nonredundantly recruit the retromer complex to the endosomes in Fusarium graminearum被引量：1
《Stress Biology》2021年第1期203-214,共12页Yakubu Saddeeq Abubakar Han Qiu Wenqin Fang Huawei Zheng Guodong Lu Jie Zhou Zonghua Wang Wenhui Zheng 
supported by grants from the National Natural Science Foundation of China(31772106)and the Natural Science Foundation of Fujian Province(2021J06015).The funders had no role in the study design,data collection and analysis,decision to publish,or preparation of the manuscript.
The retromer complex,composed of the cargo-selective complex(CSC)Vps35-Vps29-Vps26 in complex with the sorting nexin dimer Vps5-Vps17,mediates the sorting and retrograde transport of cargo proteins from the endosomes ...
关键词：Fusarium graminearum Rab GTPases RETROMER vesicle trafficking 
Evaluation of the reducing potential of PSMA-containing endosomes by FRET imaging被引量：2
《Cancer Drug Resistance》2021年第1期223-232,共10页Chelvam Venkatesh Jiayin Shen Karson S.Putt Philip S.Low 
Aim:Ligand-targeted therapeutics are experiencing increasing use for treatment of human diseases due to their ability to concentrate a desired drug at a pathologic site while reducing accumulation in healthy tissues.F...
关键词：DUPA prostate-specific membrane antigen ENDOSOMES ENDOCYTOSIS 
Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease被引量：1
《Translational Neurodegeneration》2020年第2期290-308,共19页Ruinan Shen Xiaobei Zhao Lu He Yongbo Ding Wei Xu Suzhen Lin Savannah Fang Wanlin Yang Kijung Sung Brian Spencer Robert A.Rissman Ming Lei Jianqing Ding Chengbiao Wu 
The project was financially supported by the National Natural Science Foundation of China[#81630029 and#81871005 for JD];the National Key R&D Program of China[#2016YFC13060000 for JD].UCSD ADRC P50 Pilot Grant(Wu).
Background In Alzheimer’s Disease(AD),about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways.Among them,the Ras and Rab Interactor 3(RIN3)is a guani...
关键词：Alzheimer's disease(AD) AD risk factors ENDOSOMES TRAFFICKING RIN3 BIN1 CD2AP Tau 
Endosomes and Microtubles are Required for Productive Infection in Aquareovirus被引量：2
《Virologica Sinica》2020年第2期200-211,共12页Fuxian Zhang Hong Guo Qingxiu Chen Zheng Ruan Qin Fang 
This work is supported in part by grants from the National Natural Science Foundation of China(31672693,31972838 and 31400139,31372565).
Grass carp reovirus(GCRV),the genus Aquareovirus in family Reoviridae,is viewed as the most pathogenic aquareovirus.To understand the molecular mechanism of how aquareovirus initiates productive infection,the roles of...
关键词：AQUAREOVIRUS Cell entry Quantum dot ENDOSOME MICROTUBULE 
Involvement of SNX1 in regulating EGFR endocytosis in a gefitinib-resistant NSCLC cell lines被引量：1
《Cancer Drug Resistance》2019年第3期539-549,共11页Yukio Nishimura Kazuyuki Itoh 
The drug gefitinib, a specific inhibitor of EGFR tyrosine kinase, has been shown to suppress the activation of EGFR signaling for survival and cell proliferation in non-small cell lung cancer cell lines. For many year...
关键词：Lung cancer DRUG-RESISTANCE EGFR ENDOCYTOSIS endosomes/lysosomes sorting nexin 1 membrane recycling 
Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models被引量：1
《Translational Neurodegeneration》2019年第1期433-449,共17页Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler 
This work has been developed and supported through the LABEX(excellence laboratory,program investment for the future)DISTALZ(Development of lnnovative Strategies for a Transdisciplinary approach to ALZheimers disease)and by Fondation Alzheimer.A.Be and A.Bo were granted from DISTALZ.
Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with th...
关键词：Extracellular vesicles C99 APP-CTFs Homo-and hetero-oligomerization ENDOSOMES LYSOSOMES trans-Golgi network SorLA γ-Secretase inhibition Presenilin knockout Alzheimer’s disease 
Interleukin-6 secretion is limited by self-signaling in endosomes被引量：2
《Journal of Molecular Cell Biology》2019年第2期144-157,共14页Danielle R.J.Verboogen Natalia H.Revelo Martin ter Beest Geert van den Bogaart 
Cells producing cytokines often express the receptor for the same cytokine, which makes them prone to autocrine signaling. How cytokine release and signaling are regulated in the same cell is not understood? In this s...
关键词：membrane TRAFFICKING cytokine release EXOCYTOSIS INTERLEUKIN-6 endosomal SIGNALING 
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