LYSOSOMES

作品数：43被引量：204H指数：8
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相关领域：医药卫生生物学更多>>
相关作者：秦正红张慧灵秦爱萍屈凌波陈忠斌更多>>
相关机构：苏州大学郑州大学军事医学科学院更多>>
相关期刊：《Hepatobiliary & Pancreatic Diseases International》《Signal Transduction and Targeted Therapy》《Asian Journal of Pharmaceutical Sciences》《Translational Neurodegeneration》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Roles of neuronal lysosomes in the etiology of Parkinson’s disease被引量：1
《Neural Regeneration Research》2024年第9期1981-1983,共3页Mattia Volta 
supported by grants from Parkinson Canada,The Weston Brain Foundation and the Euregio Science Fund(to MV).
Therapeutic progress in neurodegenerative conditions such as Parkinson’s disease has been hampered by a lack of detailed knowledge of its molecular etiology.The advancements in genetics and genomics have provided fun...
关键词：ALPHA-SYNUCLEIN autophagy LRRK2 LYSOSOME neuroprotection NEUROTRANSMISSION Parkinson’s disease Rit2 SYNAPSE 
Supramolecular Manipulation of Intracellular Acidic Vesicles to Improve Cellular Self-Repair and Self-Defense
《CCS Chemistry》2024年第6期1487-1498,共12页Ziyi Wang Chen Sun Yu Dong Yuan-Fu Ding Chen Zhao Ian Wa Ho Jiahong Lu Ruibing Wang 
The National Natural Science Foundation of China(grant nos.21871301,22071275,and 22201056)is gratefully acknowledged for providing financial support for this work。
Lysosomes are the“cell stomach”that digests various species including macromolecules and pathogens for self-repair and self-defense upon fusion with endosomes,autophagosomes,and phagosomes.Therefore,artificially man...
关键词：supramolecular chemistry organelle regulation intracellular acidic vesicles LYSOSOMES selfdefense SELF-REPAIR 
Impaired lysosomes in the retinal pigment epithelium play a central role in the degeneration of the neuroretina被引量：1
《Neural Regeneration Research》2023年第12期2697-2698,共2页Rebecca D.Miller J.Arjuna Ratnayaka 
Ph D Studentships from the Macular Society,Biotechnology and Biological Sciences Research Council (BBSRC) So Co Bio-DTP;funding from the Gi?t of Sight Appeal。
Lysosomes are highly dynamic, single membranebound compartments that are critical for maintaining cellular homeostasis. These organelles, which appear to vary between 200 nm–1 μm in diameter, originate from the matu...
关键词：CRITICAL dynamic DEGENERATION 
KCNJ15 deficiency promotes drug resistance via affecting the function of lysosomes被引量：1
《Asian Journal of Pharmaceutical Sciences》2023年第3期132-145,共14页Xinbo Qiao Yixiao Zhang Zhan Zhang Nan Niu Haonan Li Lisha Sun Qingtian Ma Jiawen Bu Jinchi Liu Guanglei Chen Jinqi Xue Yongliang Yang Caigang Liu 
supported by the National Natural Science Foundation of China(#81872159,#81902607,and#81874301);the Liaoning Colleges Innovative Talent Support Program(#Cancer Stem Cell Origin and Biology Behavior);the Major Project Construction Foundation of China Medical University(#2017ZDZX05);the Outstanding Scientific Fund of Shengjing Hospital(#201803);the Outstanding Young Scholars of Liaoning Province(#2019-YQ-10).
The altered lysosomal function can induce drug redistribution which leads to drug resistance and poor prognosis for cancer patients.V-ATPase,an ATP-driven proton pump positioned at lysosomal surfaces,is responsible fo...
关键词：Breast cancer Cancer progression Drug resistance LYSOSOME KCNJ15 
Sodium alginate coating simultaneously increases the biosafety and immunotherapeutic activity of the cationic mRNA nanovaccine被引量：2
《Acta Pharmaceutica Sinica B》2023年第3期942-954,共13页Xing Duan Yi Zhang Mengran Guo Na Fan Kepan Chen Shugang Qin Wen Xiao Qian Zheng Hai Huang Xiawei Wei Yuquan Wei Xiangrong Song 
supported by the National Key Research and Development Program of China(2021YFE0206600);the Sichuan Province Science and Technology Support Program(2021YF-SY0008 and 2020YJ023,China);the Translational Medicine Fund of West China Hospital(CGZH19002,China);the 1.3.5 Project for Disciplines of excellence,West China Hospital,Sichuan University(ZYGD18020/ZYJC18006,China).
The extraordinary advantages associated with mRNA vaccines,including their high efficiency,relatively low severity of side effects,and ease of manufacture,have enabled them to be a promising immunotherapy approach aga...
关键词：Negatively charged mRNA vaccine Sodium alginate Cationic liposome DOTAP Lysosomes escape Cancer Immunotherapy Toxicity 
CLN3 clinches lysosomes in clearance of glycerophospholipids
《Life Metabolism》2023年第1期6-7,共2页Guang Lu Han-Ming Shen 
CLN3 is a lysosomal transmembrane protein and loss of CLN3 is known to cause a juvenile lethal neurodegenerative lysosomal storage disorder(LSD),called Batten disease.In a recent study published in Nature,Laqtom et al...
关键词：CLN3 PHOSPHOLIPIDS establishing 
CLN3 is required for the clearance of glycerophosphodiesters from lysosomes
《四川生理科学杂志》2022年第9期1639-1639,共1页Nouf N Laqtom 
Lysosomes have many roles,including degrading macromolecules and signalling to the nucleus1.Lysosomal dysfunction occurs in various human conditions,such as common neurodegenerative diseases and monogenic lysosomal st...
关键词：CLN3 ELEVATED OCCUPY 
The role of lysosomes in alpha-synucleinopathies: a focus on glial cells
《Neural Regeneration Research》2022年第7期1486-1488,共3页Denise Balta Friederike Zunke 
supported by the Interdisciplinary Center for Clinical Research(IZKF)at the University Hospital of the University of Erlangen-Nuremberg(JochenKalden funding programme N8)。
Lysosomes are the major degradative compartments within eukaryotic cells.Besides their role in the degradation and recycling of intra-and extracellular molecules,they further mediate important biological processes,suc...
关键词：HOMEOSTASIS RECYCLING degradation 
SARS-CoV-2 treatment effects induced by ACE2-expressing microparticles are explained by the oxidized cholesterolincreased endosomal pH of alveolar macrophages被引量：2
《Cellular & Molecular Immunology》2022年第2期210-221,共12页Zhenfeng Wang Jiadi Lv Pin Yu Yajin Qu Yabo Zhou Li Zhou Qiangqiang Zhu Shunshun Li Jiangping Song Wei Deng Ran Gao Yuying Liu Jiangning Liu Wei-Min Tong Chuan Qin Bo Huang 
supported by the National Natural Science Foundation of China(81788101,91942314);CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-1-021).
Exploring the cross-talk between the immune system and advanced biomaterials to treat SARS-CoV-2 infection is a promising strategy.Here,we show that ACE2-overexpressing A549 cell-derived microparticles(AO-MPs)are a po...
关键词：SARS-CoV-2 MICROPARTICLES Alveolar macrophages ENDOSOMES LYSOSOMES 
Targeting lysosomes in human disease:from basic research to clinical applications被引量：3
《Signal Transduction and Targeted Therapy》2021年第12期3393-3420,共28页Mengdie Cao Xiangyuan Luo Kongming Wu Xingxing He 
This research was financially supported by the National Natural Science Foundation of China(No.82073095).
In recent years,accumulating evidence has elucidated the role of lysosomes in dynamically regulating cellular and organismal homeostasis.Lysosomal changes and dysfunction have been correlated with the development of n...
关键词：CLINICAL METABOLISM IMMUNITY 
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