LYSOSOME

作品数：176被引量：900H指数：12
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相关领域：医药卫生生物学更多>>
相关作者：魏富鑫王宁赵圣国王乐刘丹更多>>
相关机构：安徽医科大学合肥工业大学中国农业科学院北京畜牧兽医研究所中山大学附属第一医院更多>>
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ABCA5 lipid transporter is associated with a reduced risk of Parkinson’s disease
《Neural Regeneration Research》2026年第2期669-670,共2页Jasmin Galper Nicolas Dzamko Woojin Scott Kim 
A key pathological feature of Parkinson’s disease(PD)is that lysosomes are overwhelmed with cellular materials that need to be degraded and cleared.While the build-up of protein is characteristic of neurodegenerative...
关键词：neurodegenerative diseases lipid transporter abca LYSOSOME protein build up Alzheimers disease cellular materials Parkinsons disease 
Pathological axonal enlargement in connection with amyloidosis,lysosome destabilization,and bleeding is a major defect in Alzheimer’s disease
《Neural Regeneration Research》2026年第2期790-799,共10页Hualin Fu Jilong Li Chunlei Zhang Guo Gao Qiqi Ge Xinping Guan Daxiang Cui 
supported by the National Natural Science Foundation of China,No.81472235(to HF);the Shanghai Jiao Tong University Medical and Engineering Project,Nos.YG2021QN53(to HF),YG2017MS71(to HF);the International Cooperation Project of the National Natural Science Foundation of China,No.82020108017(to DC);the Innovation Group Project of the National Natural Science Foundation of China,No.81921002(to DC).
Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-βdeposits in brain blood vessels,microaneurysms,and senile plaques.How amyloid-βdeposition affects axon pathology has not been examined ex...
关键词：Alzheimer’s disease amyloid-β AMYLOIDOSIS axonal enlargement hemoglobin hemorrhage lysosome destabilization neuropil thread tau Wallerian degeneration 
Amino-modified IONPs potentiates ferroptotic cell death due to the release of Fe ion in the lysosome
《Journal of Environmental Sciences》2025年第4期1-13,共13页Zijuan Qi Xiaofeng Huang Jiajun Jing Wenya Feng Ming Xu Li Yan Ming Gao Sijin Liu Xue-Feng Yu 
supported by the National Natural Science Foundation of China(Nos.22076212 and 22222611);the Youth Innovation Promotion Association of CAS(No.2021040).
Iron oxide nanoparticles(IONPs)have wide applications in the biomedical field due to their outstanding physical and chemical properties.However,the potential adverse effects and relatedmechanisms of IONPs in human org...
关键词：Iron oxide nanoparticles(IONPs) Surface functionalization Iron homeostasis Ferroptosis 
The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease
《Neural Regeneration Research》2025年第1期139-158,共20页Fengjuan Jiao Lingyan Meng Kang Du Xuezhi Li 
supported by the National Natural Science Foundation of China,No.82101340(to FJ).
Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in neurons.As one of the major intracellular...
关键词：AUTOPHAGY chemical therapy gene therapy Parkinson’s disease Α-SYNUCLEIN 
Targeted degradation of membrane and extracellular proteins with LYTACs
《Acta Pharmacologica Sinica》2025年第1期1-7,共7页Yu-yang Li Yang Yang Ren-shuai Zhang Rui-xin Ge Song-bo Xie 
This work was supported by the National Natural Science Foundation of China(32270892 and 32070708);Henan Province Key Research and development and promotion special(Science and technology research):No.242102311036.
Targeted protein degradation technology has gained substantial momentum over the past two decades as a revolutionary strategy for eliminating pathogenic proteins that are otherwise refractory to treatment.Among the va...
关键词：targeted protein degradation lysosome targeting chimera lysosome-trafficking receptor extracellular protein membraneprotein 
GDF11 restores the impaired function of EPCs-MA by promoting autophagy:GDF11 ameliorates endothelial progenitor cell aging by promoting autophagy
《Frigid Zone Medicine》2024年第4期212-223,共12页Donghua Liu Yang Zhang Xin Liu Qihe Huang Xiaofang Zhang Rui Yang Yue Zhao Penghui Li Jiayi He Kexiao Zhang Zhenwei Pan Huiwen Liu Baofeng Yang 
the National Natural Science Foundation of China(81421063);China Postdoctoral Science Foundation(2016M591556);Natural Science Foundation of Heilongjiang Province of China(H2016008);Postdoctoral Science Foundation of Heilongjiang Province of China(LBH-Z15146);Research Project of the Health and Family Planning Commission of Heilongjiang Province(2016-166).
Objective:Our study aimed to assess the effects of Growth and differentiation factor 11(GDF11)on the function of endothelial progenitor cells in middle-age individuals(EPCs-MA)isolated from mouse bone marrow and to ex...
关键词：GDF11 endothelial progenitor cells autophagy lysosome pathway AGING 
ZEB1-AS1 as a TRPML1 Inhibitor to Cause Lysosome Dysfunction and Cardiac Damage in Aged Mice
《Engineering》2024年第12期183-200,共18页Heng Liu Haiying Zhang Han Lou Jennifer Wang Shengxin Hao Hui Chen Chen Chen Lei Wang Huimin Li Ziyu Meng Wenjie Zhao Tong Zhao Yuan Lin Zhimin Du Xin Liu Baofeng Yang Yong Zhang 
funded by the National Natural Science Foundation of China(82273919,82270396,and U21A20339);the China Postdoctoral Science Foundation(2023T160176)。
The prevalence of cardiovascular diseases(CVDs)has increased markedly as the world population has aged.Long non-coding RNAs(lncRNAs)have been reported as novel regulators in diverse pathophysiological conditions.Here,...
关键词：Heart aging Cardiomyocytes senescence ZEB1-AS1 TRPML1 LYSOSOME 
Ginsenoside Rg1 mitigates cerebral ischaemia/reperfusion injury in mice by inhibiting autophagy through activation of mTOR signalling
《Acta Pharmacologica Sinica》2024年第12期2474-2486,共13页Zhi-chao Xi Han-gui Ren Lin Ai Yuan Wang Meng-fan Liu Yu-fei Qiu Ji-ling Feng Wang Fu Qian-qian Bi Feng Wang Hong-xi Xu 
supported by Natural Science Foundation of Shanghai(23ZR1448700);Shanghai Science and Technology Commission:Scientific and Technological Innovation Action Plan Medical Innovation Research Special Project(23Y11906400);Outstanding Leaders Training Program of Pudong Health Bureau of Shanghai(PWR12020-03);The Shanghai University of Traditional Chinese Medicine Budget Project(23KFL041).
Reperfusion injury,which is distinct from ischaemic injury,occurs when blood flow is restored in previously ischaemic brain tissue,further compromising neurons and other cells and worsening the injury.There is current...
关键词：ischaemic stroke cerebral ischaemia/reperfusion injury ginsenoside Rg1 AUTOPHAGY lysosome function MTOR 
Autophagy mediated tubulobulbar complex components degradation is required for spermiation
《Fundamental Research》2024年第6期1557-1567,共11页Liying Wang Ruidan Zhang Bingbing Wu Yang Yu Wei Li Shiguo Li Chao Liu 
supported by the National Science Fund for Distinguished Young Scholars(81925015);the Youth Innovation Promotion Association of CAS(2018109).
Spermiation is the process that releases mature spermatids from Sertoli cells into the lumen of the seminiferous tubule.Tubulobulbar complexes(TBCs)are elaborate cytoskeleton-related structures that are indispensable ...
关键词：AUTOPHAGY SPERMIATION Tubulobulbar complexes Cytoskeleton degradation Sertoli cells LYSOSOME 
TFEB/LAMP2 contributes to PM_(0.2)-induced autophagy-lysosome dysfunction and alpha-synuclein dysregulation in astrocytes
《Journal of Environmental Sciences》2024年第11期117-127,共11页Ben Li Ting Liu Yongmei Shen Jiangnan Qin Xiaohan Chang Meiqiong Wu Jianquan Guo Liangpo Liu Cailing Wei Yi Lyu Fengjie Tian Jinzhu Yin Tong Wang Wenping Zhang Yulan Qiu 
supported by the National Science Foundation of China(No.21906100);the Applied Basic Research Project of Shanxi Province(Nos.201901D211333,201901D211327,and 202203021211246).
Atmospheric particulatematter(PM)exacerbates the risk factor for Alzheimer’s and Parkinson’s diseases(PD)by promoting the alpha-synuclein(α-syn)pathology in the brain.However,the molecular mechanisms of astrocytes ...
关键词：PM_(0.2) ASTROCYTES α-Synuclein Autophagy-lysosome 
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