Α-SYNUCLEIN

作品数：335被引量：670H指数：11
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Neuronal guidance signaling in neurodegenerative diseases:Key regulators that function at neuron-glia and neuroimmune interfaces
《Neural Regeneration Research》2026年第2期612-635,共24页Junichi Yuasa-Kawada Mariko Kinoshita-Kawada Masaki Hiramoto Satoru Yamagishi Takayasu Mishima Shin’ichiro Yasunaga Yoshio Tsuboi Nobutaka Hattori Jane Y.Wu 
supported by JSPS(KAKENHI:21K06205,23K06937,24K23419);AMED(to JYK,SaY,TM,SiY,YT,and NH);JYW had long been supported by the NIH.
The nervous system processes a vast amount of information,performing computations that underlie perception,cognition,and behavior.During development,neuronal guidance genes,which encode extracellular cues,their recept...
关键词：amyloid-β axon guidance NEURODEGENERATION neuroimmune interactions neuroinflammation neuron-glia interactions neurovascular interactions SEMAPHORIN synaptic remodeling tau TDP-43 TREM2 Α-SYNUCLEIN 
Hidden face of Parkinson's disease:Is it a new autoimmune disease?
《Neural Regeneration Research》2026年第1期57-61,共5页Min Gi Jo Seon-Hee Kim Seung Pil Yun 
supported by the National Research Foundation of South Korea(2023R1A2C2004516,RS-2023-00219399 to SPY,and 2022R1I1A1A01063513 to MGJ)。
Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease is the ac...
关键词：ASTROCYTE autoimmune response biomarkers clinical implication major histocompatibility complex/human leukocyte antigen MICROGLIA neurodegenerative disease NEUROINFLAMMATION Parkinson's disease T cells Α-SYNUCLEIN 
Targeting the glymphatic system to promoteα-synuclein clearance:a novel therapeutic strategy for Parkinson's disease
《Neural Regeneration Research》2026年第1期233-247,共15页Xiaoyue Lian Zhenghao Liu Zuobin Gan Qingshan Yan Luyao Tong Linan Qiu Yuntao Liu Jiang-fan Chen Zhihui Li 
supported by the National Natural Science Foundation of China,No.81971031(to ZL);the National Key Research and Development Program of China,No.2022YFE0210100(to JFC);the National Natural Science Foundation of China(Original Exploration Project),No.82151308(to JFC);the National Natural Science Foundation of China(Research Fund for International Senior Scientists),No.82150710558(to JFC);Science&Technology Initiative STI2030-Major Projects,No.2021ZD0203400(to JFC);Key Research and Development Program of Zhejiang Province,No.2023C03079(to JFC);Scientific Research Starting Foundation of Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine,Vision and Brain Health),No.OJQDSP2022007(to JFC);Project of State Key Laboratory of Ophthalmology,Optometry and Visual Science,Wenzhou Medical University,No.J01-20190101(to JFC);Scientific Research Starting Foundation of Wenzhou Medical University,No.QTJ12003(to JFC);Department of Science and Technology of Zhejiang Province,No.2023ZY1011(to JFC)。
The excessive buildup of neurotoxicα-synuclein plays a pivotal role in the pathogenesis of Parkinson's disease,highlighting the urgent need for innovative therapeutic strategies to promoteα-synuclein clearance,parti...
关键词：AQUAPORIN-4 ASTROCYTES cerebrospinal fluid glymphatic system interstitial fluid neurotoxic protein clearance Parkinson's disease perivascular spaces sleep disturbance Α-SYNUCLEIN 
Potential biofluid markers for cognitive impairment in Parkinson's disease
《Neural Regeneration Research》2026年第1期281-295,共15页Jieyu Chen Chunyu Liang Fang Wang Yongyun Zhu Liuhui Zhu Jianzhun Chen Bin Liu Xinglong Yang 
supported by Applied Basic Research Foundation of Yunnan Province,Nos.202301AS070045,202101AY070001-115(to XY and BL);National Natural Science Foundation of China,No.81960242(to XY)。
Cognitive impairment is a particularly severe non-motor symptom of Parkinson's disease that significantly diminishes the quality of life of affected individuals.Identifying reliable biomarkers for cognitive impairment...
关键词：amyloid-β biomarkers cognitive impairment DEMENTIA metabolomics NEURODEGENERATION NEUROINFLAMMATION Parkinson's disease proteomics tau Α-SYNUCLEIN 
Gut–brain axis and environmental factors in Parkinson's disease:bidirectional link between disease onset and progression
《Neural Regeneration Research》2025年第12期3416-3429,共14页Soo Jung Park Kyung Won Kim Eun Jeong Lee 
supported by the National Research Foundation(NRF)of Korea(2022R1C1C1005741 and RS-2023-00217595)。
Parkinson's disease has long been considered a disorder that primarily affects the brain,as it is defined by the dopaminergic neurodegeneration in the substantia nigra and the brain accumulation of Lewy bodies contain...
关键词：gut inflammation gut microbiome gut-brain axis micro/nano-plastics Parkinson’s disease Α-SYNUCLEIN 
Immunoassay development guidelines for neurodegenerative disorders:lessons from a failed pS129-α-synuclein electrochemiluminescence immunoassay
《Neural Regeneration Research》2025年第10期2906-2908,共3页Hash Brown Taha Alanna Morris 
An aging population is a double-edged sword.On one hand,advancements in biotechnology and healthcare allow more people to enjoy longer lives.On the other hand,increases in the aging population accompany a surge in age...
关键词：AGING DEGENERATIVE necessarily 
Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment
《Neural Regeneration Research》2025年第9期2598-2610,共13页Yi Wang Yuning Li Yakun Gu Wei Ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu 
supported by the Scientific Research Project of China Rehabilitation Research Center,No.2021zx-23;the National Natural Science Foundation of China,No.32100925;the Beijing Nova Program,No.Z211100002121038。
Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this condition.The aims of this study were to...
关键词：BIOMARKER high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment 
TFE3-mediated neuroprotection:Clearance of aggregatedα-synuclein and accumulated mitochondria in the AAV-α-synuclein model of Parkinson's disease
《Genes & Diseases》2025年第2期368-382,共15页Xin He Mulan Chen Yepeng Fan Bin Wu Zhifang Dong 
supported by the National Natural Science Foundation of China (No.32371030,82071395);the CQMU Program for Youth Innovation in Future Medicine (Chongqing,China) (No.wo044);the Natural Science Foundation of Chongqing,China (No.CSTB2022NSCQBHX0022,CSTB2024NSCQ-LZX0008).
Parkinson's disease(PD)is a neurodegenerative disorder characterized by fibrillar neuronal inclusions containing aggregatedα-synuclein(α-Syn).While the pathology of PD is multi-faceted,the aggregation ofα-Syn and m...
关键词：Α-SYNUCLEIN Autophagy Mitochondrial biogenesis MITOPHAGY Parkinson's disease TFE3 
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson’s disease in mice by eliminating RTP801 andα-synuclein autophagic degradation obstacle
《Acta Pharmacologica Sinica》2025年第2期308-325,共18页Sha-sha Wang Ye Peng Ping-long Fan Jun-rui Ye Wen-yu Ma Qing-lin Wu Hong-yun Wang Ya-juan Tian Wen-bin He Xu Yan Zhao Zhang Shi-feng Chu Nai-hong Chen 
supported by the National Key R&D Program of China(2022YFC3500300);the National Natural Science Foundation of China(82130109,81973499);the CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-I2M-1-020).
Emerging evidence shows that psychological stress promotes the progression of Parkinson’s disease(PD)and the onset of dyskinesia in non-PD individuals,highlighting a potential avenue for therapeutic intervention.We p...
关键词：Parkinson's disease(PD) psychological stress RG1 RTP801 a-Synuclein AUTOPHAGY 
Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease
《Neural Regeneration Research》2025年第1期199-200,共2页Srishti Chawla Mikael Molin Thomas Nystrom 
Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and mammals.Its biological functions range from ion homeostas...
关键词：ACTIVATION DINUCLEAR CONSERVED 
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