supported by Applied Basic Research Foundation of Yunnan Province,Nos.202301AS070045,202101AY070001-115(to XY and BL);National Natural Science Foundation of China,No.81960242(to XY)。
Cognitive impairment is a particularly severe non-motor symptom of Parkinson's disease that significantly diminishes the quality of life of affected individuals.Identifying reliable biomarkers for cognitive impairment...
The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions a...
Background:To understand the current situation of loneliness and dementia fear among elderly people in the community;Analyze the influencing factors and clarify the correlation between the two.Methods:Through convenie...
funded by Taif University,Saudi Arabia;The author would like to acknowledge Deanship of Graduate Studies and Scientific Research,Taif University for funding this work.
The evolving field of Alzheimer’s disease(AD)diagnosis has greatly benefited from deep learning models for analyzing brain magnetic resonance(MR)images.This study introduces Dynamic GradNet,a novel deep learning mode...
After brewing a cup of coffee,85-year-old Dai Xiuyu suddenly forgets the steps she just learned and turns to a social worker for guidance-this scene replayed daily at Unforgettable Cafe in Chengdu,capital of southwest...
The aging global population is driving an increase in dementia,making the early identification of at-risk individuals crucial.Studies have shown that elderly people often exhibit a slowing gait before dementia diagnos...
supported by the National Natural Science Foundation of China(Grant Nos.62071451,62331025,and U21A20447);the National Key Research and Development Project(Grant No.2021YFC3002204);the CAMS Innovation Fund for Medical Sciences(Grant No.2019-I2M-5-019).
Dementias such as Alzheimer disease(AD)and mild cognitive impairment(MCI)lead to problems with memory,language,and daily activities resulting from damage to neurons in the brain.Given the irreversibility of this neuro...
funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University,through the Research Groups Program Grant No.(RGP-1444-0057).
Dementia is a neurological disorder that affects the brain and its functioning,and women experience its effects more than men do.Preventive care often requires non-invasive and rapid tests,yet conventional diagnostic ...
Background:This study aimed to evaluate the impact of the clock drawing test(CDT)on postoperative delirium and compare the abilities of the mini-cognitive(Mini-Cog)test and the CDT for predicting postoperative deliriu...
funding support from the National Natural Science Foundation of China(81971016);Shanghai Science and Technology program(21010502300);Construction project of Shanghai Key Laboratory of Molecular Imaging(18DZ2260400).
Dementia is characterized by synaptic and neuronal dysfunction in disease-specific brain regions.Repeated failure of dementia clinical trials with therapeutic drugs targeting abnormal protein aggregates has caused res...