an Association of British Neurologists Doctoral Research Fellowship co-funded by the Berkeley Foundation and the Stroke Association;supported by a NIHR Academic Clinical Lectureship in Neurology CL-2020-04-004 NIHR;supported by the NIHR Sheffield Biomedical Research Centre(BRC);NIHR Sheffield Clinical Research Facility(CRF);supported by NIHR EME Project Grant NIHR133169;funded by Alzheimer’s Research UK Senior Research Fellowship(ARUK-SRF2017B-1)。
Stroke remains a leading cause of long-term disability worldwide.There is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological recovery.Transc...
supported by the National Natural Science Foundation of China,No.82371444(to YZ);the Natural Science Foundation of Hubei Province,No.2022CFB216(to XC);the Key Research Project of Ministry of Science and Technology of China,No.2022ZD021160(to YZ)。
The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental challenges.In the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an impo...
The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for centuries.The aging process alters the brain structure that affects functions a...
supported by the National Natural Science Foundation of China,Nos.82271327 (to ZW),82072535 (to ZW),81873768 (to ZW),and 82001253 (to TL)。
The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and ce...
supported by the Department of Veterans Affairs(VA Merit Award BX004256)(to AMA);Emory Department of Neurosurgery Catalyst Grant;Emory Medical Care Foundation Grant(to AMA and JG)。
Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery...
Guizhou Administration of TCM,Traditional Chinese medicine,Ethnic Medicine Science and Technology Research Special Project,Grant/Award Number:QZYY-2022-008;Subsidy Fund for Scientific Research and Innovation Exploration Project,National Natural Science Foundation of China of Guizhou University of Traditional Chinese Medicine,Grant/Award Number:2018YFC170810502;Science and Technology Fund Project of Guizhou Provincial Health Commission,Grant/Award Number:gzwkj2023-147;Development of animal models for drug discovery-brain diseases.National Research and Development Project of China,MOST,Grant/Award Number:2023YFF0724802.
Background:Qingyangshen(Cynanchum otophyllum C.K.Schneid)is a folk drug for treating depression and other mental disorders induced by social defeat stress.Neuroplasticity in the hippocampus is essential for the modula...
supported by Progetto Trapezio,Compagnia di San Paolo(67935-2021.2174)to LB,Fondazione CRT(Cassa di Risparmio di Torino,RF=2022.0618)to LB。
Brain plasticity-A universal tool with many variations:The study of brain plasticity has been gaining interest since almost a century and has now reached a huge amount of information(>80,000 results in PubMed).Overall...
This study was supported by the National Key Research and Development Program of China(2022YFF0710702);the Beijing Natural Science Foundation(7244343);The authors declare that they have no conflict of interest.
Alzheimer's disease(AD)is the most prevalent neurodegenerative disorder characterized by cognitive impairments.Despite the limited efficacy of current treatments for AD,the 1,2,4-oxadiazole structure has garnered sign...
Supported by the National Natural Science Foundation of China(No.82304746);Jinan University Innovation and Entrepreneurship Training Program for Undergraduate(No.CX21255 and CX22481)。
The hippocampus is one of the most commonly studied brain regions in the context of depression.The volume of the hippocampus is significantly reduced in patients with depression,which severely disrupts hippocampal neu...
supported by the Natural Science Foundation of Hubei Province,No.2022CBF680;Independent Scientific Research Project of Wuhan University,No.2042022kf1119(both to LD)。
Stroke is a major disorder of the central nervous system that poses a serious threat to human life and quality of life.Many stro ke victims are left with long-term neurological dysfunction,which adversely affects the ...