GLUCOCORTICOID

作品数：262被引量：642H指数：12
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相关作者：郭晓红宋志芳俞康龙陈乃宏单红卫更多>>
相关机构：第二军医大学北京大学中山大学附属第三医院中国医学科学院北京协和医学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划上海市自然科学基金国家教育部博士点基金更多>>
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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function
《Neural Regeneration Research》2025年第9期2520-2537,共18页Chonglin Su Taiqi Huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing Chen 
supported by the National Natural Science Foundation of China,No.82371444(to YZ);the Natural Science Foundation of Hubei Province,No.2022CFB216(to XC);the Key Research Project of Ministry of Science and Technology of China,No.2022ZD021160(to YZ)。
The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental challenges.In the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an impo...
关键词：brain-derived neurotrophic factor calcium signaling glucocorticoid receptor GLUCOCORTICOID glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders NEUROPLASTICITY stress 
Combining orbital intensity modulated radiation therapy with periorbital triamcinolone acetonide injection for Graves’ orbitopathy
《International Journal of Ophthalmology(English edition)》2025年第5期904-911,共8页Huan Jian Rui-Xin Ma Wei-Min He 
Supported by the Sichuan Department of Science and Technology(No.2022JDKP0010).
AIM:To evaluate the efficacy of combined orbital radiation and periorbital triamcinolone acetonide injection for patients with Graves’orbitopathy(GO)who experienced treatment failure with glucocorticoid pulse therapy...
关键词：Graves’orbitopathy thyroid ophthalmopathy orbital radiation periorbital injection glucocorticoid pulse therapy 
Treatment of thymoma with low-dose glucocorticoids before surgery for significant tumor shrinkage: A case report
《World Journal of Clinical Cases》2025年第11期54-59,共6页Jin-Kun Yao Zi-Yi He Zheng Zhu Hai-Tao Huang 
BACKGROUND Thymic epithelial neoplasms are rare malignant neoplasms originating in the thymus gland.There have been case reports of patients with advanced thymomas treated with a methylprednisolone pulse or with gluco...
关键词：THYMOMA GLUCOCORTICOID Diagnosis SHRINKAGE TREATMENT Case report 
Tau(t)ing glucocorticoid binding
《Cell Research》2025年第1期1-2,共2页Sabine Vettorazzi Jan Tuckermann 
Glucocorticoids are two-faced drugs:they have beneficial antiinflammatory effects but,on the other hand,trigger complications like osteoporosis;identifying glucocorticoid-mediated pathways responsible for side effects...
关键词：GLUCOCORTICOID DRUGS CORNERS 
Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
《Cell Research》2025年第1期23-44,共22页Wenyu Fu Meng Chen Kaidi Wang Yujianan Chen Yazhou Cui Yangli Xie Zi-Ning Lei Wenhuo Hu Guodong Sun Guiwu Huang Chaopeng He Jackie Fretz Aubryanna Hettinghouse Ronghan Liu Xianyi Cai Mingshuang Zhang Yuehong Chen Nan Jiang Minchun He Daniel HWiznia Huiyun Xu Zhe-Sheng Chen Lin Chen Kanglai Tang Hong Zhou Chuan-Ju Liu 
supported partly by NIH research grants R01AR062207,R01AR061484,R01AR076900,R01AR078035 and R01NS070328.
Glucocorticoids(GCs)are the most prescribed anti-inflammatory and immunosuppressive drugs.However,their use is often limited by substantial side effects,such as GC-induced osteoporosis(GIO)with the underlying mechanis...
关键词：drugs PRESCRIBED AFFINITY 
circFKBP8(5S,6)-encoded protein as a novel endogenous regulator in major depressive disorder by inhibiting glucocorticoid receptor nucleus translocation
《Science Bulletin》2024年第24期3826-3831,共6页Jiao Jiao Dandan Xu Yan Kong Yujia Cao Liyuan Wang Yuan Hong Ling Li Chenyu Gao Jing Liu Gaojia Zhang Jiangning Zhou Ji Dai Zhonghua Lu Yan Liu Yutian Wang Zhijun Zhang 
supported by the Chinese Science and Technology Innovation 2030-Major Project(2022ZD0211701 and 2021ZD0200700);the National Natural Science Foundation of China(82130042,81830040 and 82371532);Shenzhen Science and Technology Serial Funds(GJHZ20210705141400002,KCXFZ20211020164543006,JCYJ20220818101615033,ZDSYS202-20606100606014,and KQTD20221101093608028).
Major depressive disorder(MDD)is a debilitating mental health condition that ranks second in the global burden of human diseases[1].Despite extensive research,the etiology and pathogenesis of MDD remain poorly underst...
关键词：GLUCOCORTICOID ENDOGENOUS INHIBITING 
Role of GLCCI1 in inhibiting PI3K-induced NLRP3 inflammasome activation in asthma
《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第4期279-288,共10页Yingyu Zhang Yuanyuan Jiang Daimo Zhang Xinyue Hu Shuanglinzi Deng Xiaozhao Li Juntao Feng 
supported by National Natural Science Foundation of China(Nos.82270033;81873407);Natural Science Foundation of Hunan province(No.2022JJ30924).
Background:Glucocorticoid-induced transcript 1(GLCCI1)has been reported to be associated with the efficiency of inhaled glucocorticoids in patients with asthma.This study aimed to investigate the role of GLCCI1 in the...
关键词：ASTHMA NLRP3 inflammasome Glucocorticoid-induced transcript 1(GLCCI1) PI3K signaling pathway Macrophage 
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head
《Bone Research》2024年第4期1009-1030,共22页Wenkai Shao Bo Wang Ping Wang Shuo Zhang Song Gong Xiaodong Guo Deyu Duan Zengwu Shao Weijian Liu Lei He Fei Gao Xiao Lv Yong Feng 
supported by the National Natural Science Foundation of China (82472439,82270935,81974337,82102627);the Hubei Provincial Natural Science Foundation of China (2021CFB095);the Wuhan Knowledge Innovation Project (2022020801020468);the Project of Scientific Research Plan of Wuhan Municipal Health Commission (WX21Q19)。
Osteonecrosis of the femoral head(ONFH)is a common complication of glucocorticoid(GC)therapy.Recent advances demonstrate that sympathetic nerves regulate bone homeostasis,and GCs lower the sympathetic tone.Here,we sho...
关键词：SYMPATHETIC GLUCOCORTICOID FEMORAL 
Research progress on the mechanism of exercise against depression被引量：1
《World Journal of Psychiatry》2024年第11期1611-1617,共7页Ya-Lin Zhao Shu-Ya Sun Hao-Cheng Qin Yu-Lian Zhu Zhi-Wen Luo Yuan Qian Shuo Chen 
Supported by Nanjing Municipal Sports Bureau Research Bureau Project-Building a Sports Hospital with Chinese Medicine Characteristics to Help Sports-Health Integration,No.NJTY2023-104;Exploring a New Model of“Integration of Sport and Health”,No.JSYGY-3-2023-506.
The substantial global health burden of depression encourages the development of innovative and broadly effective interventions.This paper aimed to examine recent advancements by which exercise works as an antidepress...
关键词：EXERCISE Depression Dose-response relationship Glucocorticoid cortisol 5-hydroxy tryptamine NOREPINEPHRINE 
Clinical Value of ABCB1 and PAI-1 Gene Polymorphisms in Predicting Glucocorticoid-induced Adverse Reactions in Nephrotic Syndrome Patients
《Current Medical Science》2024年第5期923-931,共9页Ya-ling ZHAI Shuai-gang SUN Wen-hui ZHANG Hui-juan TIAN Zhan-zheng ZHAO 
supported by the General Project of Henan Natural Science Foundation(No.232300420034);the National Natural Science Foundation of China for the Youth(No.81600555);the General Project of China Postdoctoral Science Foundation(No.2018M640684)。
Objective Glucocorticoid(GC)-induced adverse reactions(ARs)have been extensively studied due to their potential impact on patients’health.This study aimed to examine the potential correlation between two polymorphism...
关键词：adenosine triphosphate-binding cassette B1 nephrotic syndrome plasminogen activator inhibitor-1 steroid-associated avascular necrosis of the femoral head steroid diabetes 
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