AFFINITY

作品数：332被引量：516H指数：11
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Enabling the immune escaped etesevimab fully-armed against SARS-CoV-2 Omicron subvariants including KP.2
《hLife》2025年第3期132-145,共14页Chao Su Juanhua He Yufeng Xie Yu Hu Xin Li Shitong Qiao Peipei Liu Min Huang Rong Zhang Liang Wang Zhen Chang Wenqiao Sun Ke Xu Jing Zhang Longxing Cao Pengcheng Han Xin Zhao Jianxun Qi Qihui Wang Mengsu Yang George Fu Gao 
supported by the National Natural Science Foundation of China(82225021);the National Key R&D Program of China(2022YFC2303403,2021YFA1300803,2021YFA1301404).
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is continuously evolving since 2019.Some monoclonal antibodies(mAbs)have been developed and widely used,such as etesevimab(CB6)developed by Eli-Lilly/Junshi.H...
关键词：etesevimab(CB6) severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) receptor-binding domain(RBD) broad-spectrum and affinity-mature antibody design(BAADesign) antibody 
Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss
《Cell Research》2025年第1期23-44,共22页Wenyu Fu Meng Chen Kaidi Wang Yujianan Chen Yazhou Cui Yangli Xie Zi-Ning Lei Wenhuo Hu Guodong Sun Guiwu Huang Chaopeng He Jackie Fretz Aubryanna Hettinghouse Ronghan Liu Xianyi Cai Mingshuang Zhang Yuehong Chen Nan Jiang Minchun He Daniel HWiznia Huiyun Xu Zhe-Sheng Chen Lin Chen Kanglai Tang Hong Zhou Chuan-Ju Liu 
supported partly by NIH research grants R01AR062207,R01AR061484,R01AR076900,R01AR078035 and R01NS070328.
Glucocorticoids(GCs)are the most prescribed anti-inflammatory and immunosuppressive drugs.However,their use is often limited by substantial side effects,such as GC-induced osteoporosis(GIO)with the underlying mechanis...
关键词：drugs PRESCRIBED AFFINITY 
Recent study on hydrophilization of polyvinylidene fluoride membrane for oily-wastewater treatment
《Chinese Journal of Chemical Engineering》2024年第12期157-186,共30页Nita Aryanti Aininu Nafiunisa Tutuk Djoko Kusworo 
supported by the World Class research Undip(WCRU)Program(Category A)from Diponegoro University(118-30/UN7.6.1/PP/2021).
Polyvinylidene fluoride(PVDF)polymer-based membranes are extensively used in wastewater treatment,yet their partially hydrophobic nature poses significant challenges.Numerous studies have focused on creating super-wet...
关键词：Membranes FILTRATION Water affinity Emulsion separation FOULING 
Antiparasitic Activity and Potential Active Compounds from Azadirachta Indica Revealed by Affinity Ultrafiltration Chromatography–Mass Spectrometry with Acetylcholinesterase and Lactate Dehydrogenases
《Journal of Analysis and Testing》2024年第4期403-414,共12页Minxia Fan Tojofaniry Fabien Rakotondrabe Guilin Chen Mingquan Guo 
the financial support from the Natural Science Foundation of Hubei Province(2021CFB263);the Opening Project of Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients(HLPAI2023003)。
Azadirachta indica(A.indica)has traditionally been used to treat parasitic diseases,while its antiparasitic compounds and their mechanism remain ambiguous.Acetylcholinesterase(AChE)and lactate dehydrogenases(LDH)are t...
关键词：Azadirachta indica Parasitic diseases UF-LC-MS Molecular docking 
Lowering^(*)CO Affinity over Cu Nanoparticles for Enhanced Electrochemical CO_(2)Conversion to Multicarbon Products at High Current Density
《CCS Chemistry》2024年第12期2950-2960,共11页Ya Zhang Qiang Zhou Xiang-Yu Lu Xiao-Yu Zhang Feng Gong Wei-Yin Sun 
supported by the National Natural Science Foundation of China(grant nos.22231006,22171131,and 52076045);supported by a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
Direct electrochemical conversion of CO_(2)to multicarbon products over small-sized Cu nanoparticles(NPs)remains a significant challenge due to the strong binding affinity between^(*)CO and Cu sites.Herein,we develope...
关键词：copper ^(*)CO affinity multicarbon products CO_(2)electroreduction metal-organic framework 
Comparative study of trastuzumab modification analysis using mono/ multi-epitope affinity technology with LC-QTOF-MS
《Journal of Pharmaceutical Analysis》2024年第11期1675-1685,共11页Chengyi Zuo Jingwei Zhou Sumin Bian Qing Zhang Yutian Lei Yuan Shen Zhiwei Chen Peijun Ye Leying Shi Mao Mu Jia-Huan Qu Zhengjin Jiang Qiqin Wang 
supported by the National Natural Science Foundation of China(Grant Nos.:82373829,82273893,and 82173773);the Natural Science Foundation of Guangdong Province,China(Grant Nos.:2021A1515220099,and 2022A1515011576);the High-End Foreign Experts Project,China(Grant No.:G2021199005L);the Science and Technology Program of Guangdong Provincial Medical Products Administration,China(Grant Nos.:2023TDZ11,and 2022ZDB04).
Dynamic tracking analysis of monoclonal antibodies(mAbs)biotransformation in vivo is crucial,as certain modifications could inactivate the protein and reduce drug efficacy.However,a particular challenge(i.e.immune rec...
关键词：Monoclonal antibody Multi-epitope affinity technology Biotransformation analysis LC-QTOF-MS Breast cancer 
Screening for Bioactive Compounds from Mulberry Leaves Combining Bio-Affinity Ultrafiltration withα-Glucosidase and Pancreatic Lipase
《Journal of Analysis and Testing》2024年第3期315-326,共12页Hui Zhang Guilin Chen Yongli Zhang Felix Wambua Muema Jun Ding Mingquan Guo 
With the growing prevalence of diabetes and obesity worldwide,the role ofα-glucosidase and lipase inhibitors has gained increasing concentration.Mulberry,a functional medicinal and edible plant,has been reported exte...
关键词：Mulberry leaves Bio-affinity ultrafiltration DIABETES OBESITY 
Identification of mitochondrial ATP synthase as the cellular target of Ru-polypyridyl-β-carboline complexes by affinity-based protein profiling
《National Science Review》2024年第8期286-297,共12页Wen-Jin Wang Yu-Yi Ling Yin Shi Xiao-Wen Wu Xuxian Su Zheng-Qiu Li Zong-Wan Mao Cai-Ping Tan 
supported by the National Natural Science Foundation of China (22022707,22177142 and 22307108);Guangdong Basic and Applied Basic Research Foundation (2024B1515040028);the Fundamental Research Funds for the Central Universities.
Ruthenium polypyridyl complexes are promising anticancer candidates,while their cellular targets have rarely been identifed,which limits their clinical application.Herein,we design a series of Ru(II)polypyridyl comple...
关键词：anticancer agents bimolecular targets chemical proteomics ATPase inhibitor ferroptosis 
A review of deep learningg methods for ligand based drug virtual screening被引量：1
《Fundamental Research》2024年第4期715-737,共23页Hongjie Wu Junkai Liu Runhua Zhang Yaoyao Lu Guozeng Cui Zhiming Cui Yijie Ding 
the National Natural Science Foundation of China(62073231,62176175,62172076);National Research Project(2020YFC2006602);Provincial Key Laboratory for Computer Information Processing Technology,Soochow University(KJS2166);Opening Topic Fund of Big Data Intelligent Engineering Laboratory of Jiangsu Province(SDGC2157);Postgraduate Research&Practice Innovation Program of Jiangsu Province.
Drug discovery is costly and time consuming,and modern drug discovery endeavors are progressively reliant on computational methodologies,aiming to mitigate temporal and financial expenditures associated with the proce...
关键词：Virtual screening Deeplearning Drug discovery Drug-targetinteraction Drug-target affinity 
Enhancing the peroxidase-like activity of MoS_(2)-based nanozymes by introducing attapulgite for antibacterial application and sensitive detection of glutathione被引量：2
《Nano Research》2024年第8期7415-7426,共12页Feng Feng Yihe Zhang Xiao Zhang Bin Mu Jiahe Zhang Wenjie Qu Wangshu Tong Minmin Liang Qi An Zhanjun Guo Lu Zhao 
supported by the National Natural Science Foundation of China(Nos.52072347 and 22272152);the Foundation of Key Laboratory of Clay Mineral Applied Research of Gansu Province,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences(No.CMAR-2022-04);Beijing Nova project(No.20220484155).
Nanozymes are next-generation of nanomaterials with enzyme-like activities.In particular,nanozymes with peroxidase(POD)-like activity have been utilized in various fields,including antibacterial,detection,degradation,...
关键词：ATTAPULGITE PEROXIDASE electron density AFFINITY ANTIBACTERIAL 
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