Research progress on the mechanism of exercise against depression  

作　　者：Ya-Lin Zhao Shu-Ya Sun Hao-Cheng Qin Yu-Lian Zhu Zhi-Wen Luo Yuan Qian Shuo Chen 

机构地区：[1]School of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing 210006,Jiangsu Province,China [2]Department of Sports Medicine,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210006,Jiangsu Province,China [3]Department of Rehabilitation Medicine,Huashan Hospital,Fudan University,Shanghai 200433,China [4]Department of Sports Medicine,Huashan Hospital,Fudan University,Shanghai 200040,China [5]Department of Outpatient,Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210006,Jiangsu Province,China

出　　处：《World Journal of Psychiatry》2024年第11期1611-1617,共7页世界精神病学杂志（英文）

基　　金：Supported by Nanjing Municipal Sports Bureau Research Bureau Project-Building a Sports Hospital with Chinese Medicine Characteristics to Help Sports-Health Integration,No.NJTY2023-104;Exploring a New Model of“Integration of Sport and Health”,No.JSYGY-3-2023-506.

摘　　要：The substantial global health burden of depression encourages the development of innovative and broadly effective interventions.This paper aimed to examine recent advancements by which exercise works as an antidepressant and recommends optimal types and quantity of exercise as supplemental therapies in treating depression.Sedentary behavior and low physical activity significantly influence the onset of depression.Being an effective treatment option,exercise can significantly reduce depression risk.Exercise exerts antidepressant effects as it modulates neurotransmitters,neuroplasticity,the immune system,and hormone levels.Effective exercise forms include yoga,strength training,and walking/jogging.Tailored exercise regimens that consider individual preferences and tolerability can improve outcomes.Regular exercise enhances general well-being and reduces depressive symptoms.Additional research is needed to understand the complex basis of exercise's effects on depression.Exercise is a cost-effective and accessible intervention for depression management that needs additional exploration.Thus,customized exercise programs,as per each patient’s needs,are essential for their successful implementation clinically.

关 键 词：EXERCISE Depression Dose-response relationship Glucocorticoid cortisol 5-hydroxy tryptamine NOREPINEPHRINE 

分 类 号：R749.4[医药卫生—神经病学与精神病学]