funded in part by Aligning Science Across Parkinson’s(ASAP-020572);NIH grants(R01NS121371 and R21NS135545);Department of Defense Congressionally Directed Medical Research Programs(W81XWH-21-1-0943);Parkinson’s Foundation(PF-IMP-1045313).
The locus coeruleus norepinephrine(LC-NE)system plays an important role in regulating brain function,and its neuronal loss has been well-documented in Parkinson’s disease(PD).The LC-NE neurodegeneration is believed t...
supported by institutional research funding provided by the National Key R&D Program of China,Ministry of Science and Technology of the People's Republic of China(grant numbers:2022YFC2304605,2022YFC2304604);Clinical Applied Research and Medical Training Fund of China Primary Health Care Foundation(grant number:so20220722jl);Wu Jieping Medical Foundation(grant number:320.6750.2023-03-11).
Background:The effect of the modality of hydrocortisone administration on clinical outcomes in patients with septic shock remains uncertain. This systematic review and meta-analysis evaluate the impact of intermittent...
Supported by Nanjing Municipal Sports Bureau Research Bureau Project-Building a Sports Hospital with Chinese Medicine Characteristics to Help Sports-Health Integration,No.NJTY2023-104;Exploring a New Model of“Integration of Sport and Health”,No.JSYGY-3-2023-506.
The substantial global health burden of depression encourages the development of innovative and broadly effective interventions.This paper aimed to examine recent advancements by which exercise works as an antidepress...
supported by the National Natural Science Foundation of China(82201564,and 32300851);the Postdoctoral Science Foundation of Zhejiang Province(ZJ2022060).
Cortical states such as high and low arousal during wakefulness or rapid eye movement(REM)and non-REM(NREM)phases of sleep are fundamental biological processes that are highly conserved across species.An intricate bal...
supported by the Corbett Estate Fund(62285-531021-41800,to EW);the Helen Vosburg McCrillus Plummer and Robert Edward Lee Plummer,Jr.Chair Fund(to JHH).
Neuron-astrocyte interactions are vital for the brain’s connectome.Understanding astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in ...
support from the National Natural Science Foundation of China(Nos.51922020,52090034 and 52221006);the Open Fund of State Key Laboratory of Organic-Inorganic Composites,Beijing University of Chemical Technology(No.OIC-202201001)is gratefully acknowledged.
Intelligent electromagnetic interference(EMI)shielding modulators with a wide tuning range and cyclic stability are urgently needed but their fabrication remains challenging.A gel-like MXene/norepinephrine ink is deve...
Transversal Project:Scenario-based Application of Wearable Devices for the Treatment of Cardiac Arrhythmias with Superficial Stimulation at the Neiguan(PC6)Point Research(BUCM-2022-JS-FW-003)。
OBJECTIVE:To observe the effects of electroacupuncture at Neiguan(PC6)at different time points on reperfusion arrhythmia(RA)after myocardial ischemia and reperfusion in rats,and to investigate the correlation of this ...
supported by a grant from the Dalian Peak Planning Project of Liaoning Province,China(No.2022DF046)
To the Editor:Norepinephrine(NE),which belongs to the catecholamine family,is increasingly produced by the sympathetic nervous system and adrenal medulla when the host is under stress.It has been demonstrated that NE ...
funded by the National Natural Science Foundation of China (Z.P.81560131);Subject Cultivation Project of Zhongnan Hospital of Wuhan University (Bo Hu,No.ZNXKPY2021002);Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University (Bo Hu,No.ZNJC202011);Qinghai Province Key R&D and Transformation Projects (S.M.2019-SF-132).
Background The benefits of early use of norepinephrine in endotoxemic shock remain unknown.We aimed to elucidate the effects of different doses of norepinephrine in early-stage endotoxemic shock using a clinically rel...
Desensitization is a process characterized by the loss of cellular response to an agonist when this is present for a long time. α1D-adrenergic receptor (α1D-AR) desensitization is important sin...