supported by grants PID2020-120308RB-I00 and PID2023-147802OB-I00 funded by MICIU/AEI/10.13039/501100011033;FEDER,UE,by Aligning Science Across Parkinson’s(ref.ASAP-020505)through the Michael J.Fox Foundation for Parkinson’s Research;by CiberNed Intramural Collaborative Projects(ref.PI2020/09);by the Spanish Fundación Mutua Madrile?a de Investigación Médica(to JLL)。
The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates that...
Dopamine,often termed the"feel-good"neurotransmitter,plays a crucial role in myriad physiological and psychological brain processes.While dopamine is primarily associated with pleasure,reward,and motivation,its effect...
funded by the National Key Research and Development Program of China(Grant No.2022YFF0706003);National Natural Science Foundation of China(Grant No.62375202).
We developed an all optic-fiber waveguide-coupled surface plasmon resonance(SPR)sensor using zirconium disulfide(ZrS_(2))and poly-dopamine(PDA)as the dielectric layer and biological cross-linker,respectively.This sens...
The present paper addresses two issues pertaining to the use of virtual reality(VR).One issue pertains to the equipment utilized.VR technology can be classified into two main categories:Immersive and non-immersive.The...
supported by an under-40 grant from the Italian Association for Alzheimer’s Research [AIRALZH AGYR2021];the Strategic University Projects–Young Researcher Independence grant [YRG2021] from the Università Campus Bio-Medico di Roma (Rome, Italy)(to LLB);Italian Ministry of Health [Research Grant:GR-2019-12370446];the American Alzheimer’s Association [AARG-22-922961](to PK)。
Despite decades of dedicated resea rch,Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disorder for which the mechanisms of onset are sti unc ear.AD is cha racterized by featured histologi...
funded in part by Aligning Science Across Parkinson’s(ASAP-020572);NIH grants(R01NS121371 and R21NS135545);Department of Defense Congressionally Directed Medical Research Programs(W81XWH-21-1-0943);Parkinson’s Foundation(PF-IMP-1045313).
The locus coeruleus norepinephrine(LC-NE)system plays an important role in regulating brain function,and its neuronal loss has been well-documented in Parkinson’s disease(PD).The LC-NE neurodegeneration is believed t...
supported in parts by National Key Scientific Instrument and Equipment Development Projects of China(Grant No.2022YFF0706000);National Natural Science Foundation of China(Grant No.62035006);Independent Innovation Found of Tianjin University,China(Grant No.2023XCG-0028);Tianjin Research Innovation Project for Postgraduate Students,China(Grant No.2022BKY064).
In producing high-performance optical biosensors,the selected coupling agent and its fixation mode play an essential role as one of the decisive conditions for antibody incubation.In this work,we designed optical fibe...
BACKGROUND Restless legs syndrome(RLS)is characterized by an urge to move with an unpleasant sensation in the lower limbs.RLS typically affects the legs.However,it can also affect several other body regions,such as th...
supported by the Young Talent Innovation Team Support Project from Zhengzhou University(No.32213280);the scientific research program of innovation platform in State Tobacco Monopoly Administration;the State Key Program of National Natural Science Foundation of China(Grant No.32130083).
Dopamine(DA)is a vital neurotransmitter,and accurate detection of its concentration is critical for both clinical diagnos-tics and neuroscience research.Due to its electrochemical activity,DA is commonly detected usin...
supported by the National Natural Science Foundation of China(NSFC:81771517,81271422);the Key Project of the 14th Five-Year Plan of Educational Science in Henan Province(2021JKZD09);the Key Scientific and Technological Project in Henan Province(212102310654);the Henan Province Medical Science and Technology Key Project Jointly Constructed by Province and Ministry(SBGJ202102189);the Key R&D and Promotion Projects in Henan Province(222102310615);Natural Science Foundation of Henan Province(242300421307);the Tai-hang Scholar Research Fund from Xinxiang Medical University;and the Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorders,the Second Affiliated Hospital of Xinxiang Medical University(XTkf11).
Palmitoyl-protein thioesterase 1(PPT1)is a lysosomal depalmitoylation enzyme that mediates protein posttranslational modifications.Loss-of-function mutation of PPT1 causes a failure of the lysosomal degradation of pal...