NEURODEGENERATION

作品数：536被引量：1884H指数：18
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相关作者：陈溪萍张延波刘冉陶陆阳杨丽更多>>
相关机构：苏州大学圣安德鲁斯大学中国医学科学院北京协和医学院南方医科大学南方医院更多>>
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Stress granules:Guardians of cellular health and triggers of disease
《Neural Regeneration Research》2026年第2期588-597,共10页Meghal Desai Keya Gulati Manasi Agrawal Shruti Ghumra Pabitra KSahoo 
supported by a grant from the Merkin Peripheral Neuropathy and Nerve Regeneration Center(to PKS);the Rutgers University Startup Fund(to PKS).
Stress granules are membraneless organelles that serve as a protective cellular response to external stressors by sequestering non-translating messenger RNAs(mRNAs)and regulating protein synthesis.Stress granules form...
关键词：apoptosis axon regeneration biomolecular condensates germline cell development mRNA transport NEURODEGENERATION NEURODEVELOPMENT PATHOPHYSIOLOGY physiological functions stress granules translation viral infection 
Neuronal guidance signaling in neurodegenerative diseases:Key regulators that function at neuron-glia and neuroimmune interfaces
《Neural Regeneration Research》2026年第2期612-635,共24页Junichi Yuasa-Kawada Mariko Kinoshita-Kawada Masaki Hiramoto Satoru Yamagishi Takayasu Mishima Shin’ichiro Yasunaga Yoshio Tsuboi Nobutaka Hattori Jane Y.Wu 
supported by JSPS(KAKENHI:21K06205,23K06937,24K23419);AMED(to JYK,SaY,TM,SiY,YT,and NH);JYW had long been supported by the NIH.
The nervous system processes a vast amount of information,performing computations that underlie perception,cognition,and behavior.During development,neuronal guidance genes,which encode extracellular cues,their recept...
关键词：amyloid-β axon guidance NEURODEGENERATION neuroimmune interactions neuroinflammation neuron-glia interactions neurovascular interactions SEMAPHORIN synaptic remodeling tau TDP-43 TREM2 Α-SYNUCLEIN 
Mitochondria-derived vesicles:New players in the game of neurodegeneration
《Neural Regeneration Research》2026年第2期679-680,共2页Laura Palumbo Domenico Nuzzo Antonella Girgenti Pasquale Picone 
supported by project Emerging Infectious Diseases One Health Basic and Translational Research Actions addressing Unmet Needs on Emerging Infectious Diseases,INF-ACT,Spoke 1 and Spoke 5,Project number PE00000007,CUP B53C20040570005(to PP and DN).
Introduction:One of the main events that regulate a cell’s well-being is cell-to-cell communication.This intercellular mechanism of information transfer is often mediated by vesicular trafficking.Mitochondrial-derive...
关键词：extracellular vesicles cell cell communication vesicular traffickingmitochondrial derived NEURODEGENERATION mitochondria derived vesicles vesicular trafficking extracellular vesicle ev first 
Topical administration of GLP-1 eyedrops improves retinal ganglion cell function by facilitating presynaptic GABA release in early experimental diabetes
《Neural Regeneration Research》2026年第2期800-810,共11页Yu-Qi Shao Yong-Chen Wang Lu Wang Hang-Ze Ruan Yun-Feng Liu Ti-Hui Zhang Shi-Jun Weng Xiong-Li Yang Yong-Mei Zhong 
supported by the National Natural Science Foundation of China,Nos.32070989(to YMZ),31872766(to YMZ),81790640(to XLY),and 82070993(to SJW);the grant from Sanming Project of Medicine in Shenzhen,No.SZSM202011015(to XLY)。
Diabetic retinopathy is a prominent cause of blindness in adults,with early retinal ganglion cell loss contributing to visual dysfunction or blindness.In the brain,defects inγ-aminobutyric acid synaptic transmission ...
关键词：diabetic retinopathy glucagon-like peptide-1 inhibitory synaptic transmission miniature inhibitory postsynaptic currents NEURODEGENERATION NEUROPROTECTION patch-clamp recording protein kinase C signaling pathway visual function 
Adeno-associated viral vectors for modeling Parkinson's disease in non-human primates
《Neural Regeneration Research》2026年第1期224-232,共9页Julia Chocarro JoséL.Lanciego 
supported by grants PID2020-120308RB-I00 and PID2023-147802OB-I00 funded by MICIU/AEI/10.13039/501100011033;FEDER,UE,by Aligning Science Across Parkinson’s(ref.ASAP-020505)through the Michael J.Fox Foundation for Parkinson’s Research;by CiberNed Intramural Collaborative Projects(ref.PI2020/09);by the Spanish Fundación Mutua Madrile?a de Investigación Médica(to JLL)。
The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates that...
关键词：adeno-associated viral vectors ALPHA-SYNUCLEIN DOPAMINE Lewy bodies NEURODEGENERATION NEUROMELANIN NEUROPATHOLOGY substantia nigra 
Synaptic and synchronic impairments in subcortical brain regions associated with early non-cognitive dysfunction in Alzheimer's disease
《Neural Regeneration Research》2026年第1期248-264,共17页Nicolás Riffo-Lepe Juliana González-Sanmiguel Lorena Armijo-Weingart Paulina Saavedra-Sieyes David Hernandez Gerson Ramos Loreto S.San Martín Luis G.Aguayo 
supported by ANID/CONICYT Fondecyt Regular 1221080(to LGA);Fondecyt Postdoctoral fellow 3210260(to LAW);ANID PhD fellowship 21202521(to NRL);21211228(to JGS);21211758(to PSS)and 21230078(to DH)。
For many decades,Alzheimer's disease research has primarily focused on impairments within cortical and hippocampal regions,which are thought to be related to cognitive dysfunctions such as memory and language deficits...
关键词：Alzheimer's disease AMPA receptors AMYGDALA epilepsy gamma-aminobutyric acid GLUTAMATE hippocampus NEURODEGENERATION neuronal excitability N-methyl-D-aspartate receptors non-cognitive nucleus accumbens 
Potential mechanisms of non-coding RNA regulation in Alzheimer's disease
《Neural Regeneration Research》2026年第1期265-280,共16页Yue Sun Xinping Pang Xudong Huang Dinglu Liu Jingyue Huang Pengtao Zheng Yanyu Wei Chaoyang Pang 
Alzheimer's disease,a progressively degenerative neurological disorder,is the most common cause of dementia in the elderly.While its precise etiology remains unclear,researchers have identified diverse pathological ch...
关键词：Alzheimer's disease biomarkers circular RNA long non-coding RNA microRNA ncRNA regulation NEURODEGENERATION non-coding RNA PATHOGENESIS therapeutic targets 
Potential biofluid markers for cognitive impairment in Parkinson's disease
《Neural Regeneration Research》2026年第1期281-295,共15页Jieyu Chen Chunyu Liang Fang Wang Yongyun Zhu Liuhui Zhu Jianzhun Chen Bin Liu Xinglong Yang 
supported by Applied Basic Research Foundation of Yunnan Province,Nos.202301AS070045,202101AY070001-115(to XY and BL);National Natural Science Foundation of China,No.81960242(to XY)。
Cognitive impairment is a particularly severe non-motor symptom of Parkinson's disease that significantly diminishes the quality of life of affected individuals.Identifying reliable biomarkers for cognitive impairment...
关键词：amyloid-β biomarkers cognitive impairment DEMENTIA metabolomics NEURODEGENERATION NEUROINFLAMMATION Parkinson's disease proteomics tau Α-SYNUCLEIN 
Positive impact of indicaxanthin from Opuntia ficusindica fruit on high-fat diet–induced neuronal damage and gut microbiota dysbiosis
《Neural Regeneration Research》2026年第1期324-332,共9页Simona Terzo Antonella Amato Pasquale Calvi Marta Giardina Domenico Nuzzo Pasquale Picone Antonio Palumbo-Piccionello Sara Amata Ilenia Concetta Giardina Alessandro Massaro Ignazio Restivo Alessandro Attanzio Luisa Tesoriere Mario Allegra Flavia Mulè 
funding from the European Union -NextGenerationEU through the Italian Ministry of University and Research under PRIN PNRR REG D.R.1718-2022– Project number PRJ-1575 INDICA。
Indicaxanthin is a betalain that is abundant in Opuntia ficus-indica orange fruit and has antioxidative and anti-inflammatory effects. Nevertheless, very little is known about the neuroprotective potential of indicaxa...
关键词：gut microbiota dysbiosis high-fat diet indicaxanthin MICROFLORA neuronal apoptosis NEURODEGENERATION NEUROINFLAMMATION obesity Opuntia ficus-indica fruit 
Understanding the link between type 2 diabetes mellitus and Parkinson's disease:role of brain insulin resistance
《Neural Regeneration Research》2025年第11期3113-3123,共11页Theodora Ntetsika Sergiu-Bogdan Catrina Ioanna Markaki 
support from Region Stockholm,ALF-project(FoUI-960041);Open Access funding is provided by Karolinska Institute(both to IM)。
Type 2 diabetes mellitus and Parkinson's disease are chronic diseases linked to a growing pandemic that affects older adults and causes significant socio-economic burden.Epidemiological data supporting a close relatio...
关键词：brain insulin resistance brain insulin signaling diabetes type 2 GLP-1 receptor agonists GLP-1 signaling insulin resistance insulin signaling NEURODEGENERATION Parkinson's disease targeted therapy 
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