PATHOPHYSIOLOGY

作品数:409被引量:2557H指数:26
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相关领域:医药卫生更多>>
相关作者:王梅梁晓军赵宏谋聂广军更多>>
相关机构:潍坊医学院国家纳米科学中心上海大学西安交通大学更多>>
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相关基金:国家自然科学基金World Health Organization广东省自然科学基金瑞士科学基金更多>>
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Stress granules:Guardians of cellular health and triggers of disease
《Neural Regeneration Research》2026年第2期588-597,共10页Meghal Desai Keya Gulati Manasi Agrawal Shruti Ghumra Pabitra KSahoo 
supported by a grant from the Merkin Peripheral Neuropathy and Nerve Regeneration Center(to PKS);the Rutgers University Startup Fund(to PKS).
Stress granules are membraneless organelles that serve as a protective cellular response to external stressors by sequestering non-translating messenger RNAs(mRNAs)and regulating protein synthesis.Stress granules form...
关键词:apoptosis axon regeneration biomolecular condensates germline cell development mRNA transport NEURODEGENERATION NEURODEVELOPMENT PATHOPHYSIOLOGY physiological functions stress granules translation viral infection 
Advancements in diabetic retinopathy:Insights and future directions
《World Journal of Methodology》2025年第2期21-26,共6页Chun-Yao Cheng Wen-Rui Hao Tzu-Hurng Cheng 
This editorial discusses recent advancements and ongoing challenges in diabetic retinopathy,as reviewed by Morya et al in their comprehensive analysis.In their review,Morya et al discussed the pathophysiology of diabe...
关键词:Diabetic retinopathy PATHOPHYSIOLOGY Novel treatments Review analysis Clinical implications 
Overview of serrated polyposis syndrome from pathophysiology,diagnosis,and management
《World Journal of Clinical Oncology》2025年第4期1-5,共5页Zong-Yang Li Tong Li Hong-Qiao Cai 
This editorial discusses Thompson et al's original article,which is published in the most recent edition of the World Journal of Clinical Oncology and sheds critical light on the intertwined issues of health anxiety a...
关键词:Serrated polyposis syndrome PATHOPHYSIOLOGY DIAGNOSIS TREATMENT Psychosocial impact 
Pathophysiology and management of crush syndrome: A narrative review
《World Journal of Orthopedics》2025年第4期58-68,共11页Shahnawaz Khan Deepak Neradi Nikhil Unnava Mantu Jain Sujit Kumar Tripathy 
BACKGROUND Crush syndrome refers to the traumatic rhabdomyolysis leading to a spectrum of disorders culminating in acute kidney injury.The burden of crush syndrome is high,and mortality can be as high as 20%.The signi...
关键词:RHABDOMYOLYSIS FRACTURE Musculoskeletal injury Acute kidney injury MYOGLOBIN MUSCLE 
T helper 17 cells and interleukin-17 immunity in type 1 diabetes:From pathophysiology to targeted immunotherapies
《World Journal of Diabetes》2025年第4期48-61,共14页Georgi Vasilev Maria Kokudeva Elina Siliogka Nathalia Padilla Russka Shumnalieva David Della-Morte Camillo Ricordi Antoaneta Mihova Marco Infante Tsvetelina Velikova 
Supported by the European Union-NextGenerationEU,through the National Recovery and Resilience Plan of the Republic of Bulgaria,No.BG-RRP-2.004-0008.
Type 1 diabetes(T1D)is a chronic organ-specific autoimmune disorder characterized by a progressive loss of the insulin-secreting pancreatic beta cells,which ultimately results in insulinopenia,hyperglycemia and lifelo...
关键词:Type 1 diabetes T helper 17 cells INTERLEUKIN-17 T helper 1 cells Regulatory T cells Anti-interleukin-17 treatment Th17-targeted treatment 
Advances in the diagnosis and management of post-percutaneous coronary intervention coronary microvascular dysfunction:Insights into pathophysiology and metabolic risk interactions
《World Journal of Cardiology》2025年第2期29-42,共14页Nan Tang Kang-Ming Li Hao-Ran Li Qing-Dui Zhang Ji Hao Chun-Mei Qi 
Percutaneous coronary intervention(PCI),as an essential treatment for coronary artery disease,has significantly improved the prognosis of patients with large coronary artery lesions.However,some patients continue to e...
关键词:Coronary microvascular dysfunction Percutaneous coronary intervention Diagnosis Management Coronary flow reserve Microvascular resistance Stem cell therapy Adverse outcomes 
Alzheimer's disease:insights into pathology,molecular mechanisms,and therapy
《Protein & Cell》2025年第2期83-120,共38页Qiuyang Zheng Xin Wang 
supported by the National Key R&D Program of China(2021ZD0202402 and 2021YFA1101401 to X.W.);the National Natural Science Foundation of China(82325018 and U21A20358 to X.W.,82271451 to Q.Z.);the Natural Science Foundation of Fujian Province of China(2021J02004 to X.W.);the Guangdong Basic and Applied Basic Research Foundation(2021B1515120081 to X.W.);the Fundamental Research Funds for the Chinese Central Universities(20720230070 to X.W.and Q.Z.,20720220052 to Q.Z.)。
Alzheimer's disease(AD),the leading cause of dementia,is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain.This condition casts a significant shadow on global health due to ...
关键词:Alzheimer's disease PATHOPHYSIOLOGY risk factors biomarkers prevention 
Bile Reflux Gastritis: A Comprehensive Review
《Open Journal of Gastroenterology》2025年第2期35-50,共16页Saeed Alzubide Shakir Bakkari 
Bile reflux gastritis (BRG) is a gastro-intestinal condition especially characterized by the reflux of bile into the stomach, further leading to mucosal inflammation along with various other clinical manifestations. D...
关键词:Bile Reflux Gastritis BRG PREVALENCE Risk Factors PATHOPHYSIOLOGY DIAGNOSIS Treatment Management 
Importance of etiologies of secondary diabetes:How often do we think off in clinical practice?
《World Journal of Clinical Cases》2025年第5期49-51,共3页Kotha Sugunakar Reddy Arvind Kumar Morya Archana Gaur Sakthivadivel Varatharajan 
The article"Secondary diabetes due to different etiologies:Four case reports"by Song et al,published in the World Journal of Clinical Cases,delves into the identi-fication of rare causes of secondary diabetes and emph...
关键词:Diabetes mellitus ETIOLOGIES Viral infections SYNDROMES Pathophysiology Secondary diabetes mellitus Clinical practice 
Oxidative stress in diabetes mellitus and its complications:From pathophysiology to therapeutic strategies
《Chinese Medical Journal》2025年第1期15-27,共13页Xingyu Chen Na Xie Lixiang Feng Yujing Huang Yuyao Wu Huili Zhu Jing Tang Yuanyuan Zhang 
supported by grants from the National Key R&D Program of China(Nos.2023YFC3402100 and 2020YFA0509400);the Guangdong Basic and Applied Basic Research Foundation(No.2019B030302012);the National Natural Science Foundation of China(Nos.81821002,82130082,82341004,82170844,and 82270613);the 1·3·5 project for disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD22007 and ZYJC21004);the Science and Technology Support Program of Sichuan Province(Nos.2023NSFSC1878,2021YFG0137,2022YFH0045,and 2022YFH0102).
Oxidative stress due to aberrant metabolism is considered as a crucial contributor to diabetes and its complications.Hyperglycemia and hyperlipemia boost excessive reactive oxygen species generation by elevated mitoch...
关键词:Oxidative stress Diabetes mellitus Diabetes complications Redox regulation Beta cell dysfunction Insulin resistance Systemic inflammation Redox signaling 
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