Alzheimer's disease:insights into pathology,molecular mechanisms,and therapy  

作　　者：Qiuyang Zheng Xin Wang 

机构地区：[1]Shenzhen Research Institute of Xiamen University,Shenzhen 518057,China [2]State Key Laboratory of Cellular Stress Biology,Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research,Institute of Neuroscience,Department of Neurology,the First Affiliated Hospital of Xiamen University,School of Medicine,Xiamen University,Xiamen 361005,China

出　　处：《Protein & Cell》2025年第2期83-120,共38页蛋白质与细胞(英文版)

基　　金：supported by the National Key R&D Program of China(2021ZD0202402 and 2021YFA1101401 to X.W.);the National Natural Science Foundation of China(82325018 and U21A20358 to X.W.,82271451 to Q.Z.);the Natural Science Foundation of Fujian Province of China(2021J02004 to X.W.);the Guangdong Basic and Applied Basic Research Foundation(2021B1515120081 to X.W.);the Fundamental Research Funds for the Chinese Central Universities(20720230070 to X.W.and Q.Z.,20720220052 to Q.Z.)。

摘　　要：Alzheimer's disease(AD),the leading cause of dementia,is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain.This condition casts a significant shadow on global health due to its complex and multifactorial nature.In addition to genetic predispositions,the development of AD is influenced by a myriad of risk factors,including aging,systemic inflammation,chronic health conditions,lifestyle,and environmental exposures.Recent advancements in understanding the complex pathophysiology of AD are paving the way for enhanced diagnostic techniques,improved risk assessment,and potentially effective prevention strategies.These discoveries are crucial in the quest to unravel the complexities of AD,offering a beacon of hope for improved management and treatment options for the millions affected by this debilitating disease.

关 键 词：Alzheimer's disease PATHOPHYSIOLOGY risk factors biomarkers prevention 

分 类 号：R749.16[医药卫生—神经病学与精神病学]