SEMAPHORIN

作品数:106被引量:248H指数:8
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相关领域:医药卫生更多>>
相关作者:潘国庆张学武宋晓萌吴煜农张红闯更多>>
相关机构:昆明医科大学南京医科大学空军军医大学(第四军医大学)青海大学更多>>
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相关基金:国家自然科学基金国家攀登计划江苏省自然科学基金北京市自然科学基金更多>>
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Neuronal guidance signaling in neurodegenerative diseases:Key regulators that function at neuron-glia and neuroimmune interfaces
《Neural Regeneration Research》2026年第2期612-635,共24页Junichi Yuasa-Kawada Mariko Kinoshita-Kawada Masaki Hiramoto Satoru Yamagishi Takayasu Mishima Shin’ichiro Yasunaga Yoshio Tsuboi Nobutaka Hattori Jane Y.Wu 
supported by JSPS(KAKENHI:21K06205,23K06937,24K23419);AMED(to JYK,SaY,TM,SiY,YT,and NH);JYW had long been supported by the NIH.
The nervous system processes a vast amount of information,performing computations that underlie perception,cognition,and behavior.During development,neuronal guidance genes,which encode extracellular cues,their recept...
关键词:amyloid-β axon guidance NEURODEGENERATION neuroimmune interactions neuroinflammation neuron-glia interactions neurovascular interactions SEMAPHORIN synaptic remodeling tau TDP-43 TREM2 Α-SYNUCLEIN 
Long noncoding RNA semaphorin 6A-antisense RNA 1 reduces hepatocellular carcinoma by promoting semaphorin 6A mRNA degradation
《World Journal of Gastroenterology》2025年第13期138-151,共14页Song-Man Yu Min Zhang Sha-Lin Li Si-Ya Pei Li Wu Xing-Wang Hu Yan-Kun Duan 
Supported by Natural Science Foundation of Hunan Province,No.2021JJ41048 and No.S2019JJQNJJ2012;and Changsha Natural Science Foundation,No.kq2208400.
BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent malignant tumor with a poor prognosis,which is often associated with chronic hepatitis B virus infection in China.Our previous study has shown that long non-codin...
关键词:Long noncoding RNA Semaphorin 6A antisense RNA 1 Semaphorin 6A Hepatocellular carcinoma Liver cancer 
胃癌中semaphorin 5A和PD-L1的表达与临床病理的相关性
《临床与实验病理学杂志》2025年第3期304-310,316,共8页彭诗岚 徐子凡 杨佳蓉 李莎 徐媛媛 潘国庆 
国家自然科学基金(82260512);云南省基础研究专项(202201AS070076)。
目的探讨胃癌中神经轴突导向分子5A(semaphorin 5A,SEMA5A)和程序性死亡配体-1(programmed death ligand-1,PD-L1)的表达及临床意义。方法收集41例胃癌组织与配对的癌旁组织临床资料,采用免疫组化法和RT-qPCR法检测SEMA5A、PD-L1的表达...
关键词:胃肿瘤 SEMA5A PD-L1 免疫组织化学 RT-QPCR 
Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery
《Neural Regeneration Research》2025年第1期224-233,共10页Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng Gang Zhang 
supported by the NIH grants,R01 NS111801(to ZGZ);American Heart Association 16SDG29860003(to YZ)。
Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional recovery.Our previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)iso...
关键词:axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke 
通过调控心脏神经生长因子和Semaphorin3a的平衡表达抑制大鼠心肌梗死后心功能恶化
《实用医技杂志》2025年第1期5-10,I0001,共7页王海雄 李泽锴 林亚如 李军 李娜 张安欣 孙跃辉 郭李平 余星燕 向杰 
山西省自然科学基金项目(20210302123346)。
目的探索大鼠心肌梗死后交感神经再生和重塑,人为调控相关因子以期减少心肌梗死后病理性重塑所引发的心功能减退,为以后研发有相应效应和特点的抗心力衰竭新药做理论准备。方法利用CRISPR/Cas9和基因敲入技术建立3种大鼠品系模型,与野生...
关键词:心肌梗死 心脏功能试验 Semaphorin 3a 神经生长因子 心力衰竭 
雌激素通过Semaphorin3A促进牙周膜干细胞的成骨分化
《中文科技期刊数据库(全文版)医药卫生》2024年第12期227-232,共6页袁学顺 张林林 周旭 贺海鹏 
深圳市医学重点学科(2020-2024年)资助项目(SZXK039),深圳市龙岗区经济与科技发展专项基金(LGKCYLWS2020090,LGWJ2021-117)。
探究雌激素(Oestrogen, E2)对牙周膜干细胞(Periodontal ligament stem cells, PDLSCs)成骨分化的影响及机制。方法 采用CCK-8法评估E2对PDLSCs增殖能力的影响。通过碱性磷酸酶活性染色、茜素红染色和实时定量聚合酶链反应(real-time qu...
关键词:雌激素 牙周膜干细胞 SEMAPHORIN 3A Wnt/β-catenin信号 
Semaphorin 3C (Sema3C) reshapes stromal microenvironment to promote hepatocellular carcinoma progression被引量:1
《Signal Transduction and Targeted Therapy》2024年第8期3429-3448,共20页Hao Peng Meng Yang Kun Feng Qingpeng Lv Yewei Zhang 
This study was supported by the National Natural Science Foundation of China(Nos.62331016,62227803,U22A2023,62325112);the Leading-edge Technology Programme of Jiangsu Natural Science Foundation:BE2022812,BK20212021。
More than 90% of hepatocellular carcinoma(HCC)cases develop in the presence of fibrosis or cirrhosis,making the tumor microenvironment(TME)of HCC distinctive due to the intricate interplay between cancer-associated fi...
关键词:SEMA HEPATOCELLULAR thereby 
Semaphorin 7A impairs barrier function in cultured human corneal epithelial cells in a manner dependent on nuclear factor-kappa B
《International Journal of Ophthalmology(English edition)》2024年第3期444-453,共10页Cheng-Cheng Yang Xiu-Xia Yang Xiao-Jing Zhao Heng Wang Zi-Han Guo Kai Jin Yang Liu Bin-Hui Li 
Supported by the National Natural Science Foundation of China(No.81770889);Zhuhai Science and Technology Program(No.ZH22036201210134PWC).
●AIM:To evaluate the role of semaphorin 7A(Sema7A)and its associated regulatory mechanisms in modulating the barrier function of cultured human corneal epithelial cells(HCEs).●METHODS:Barrier models of HCEs were tre...
关键词:human corneal epithelial barrier function transepithelial electrical resistance zonula occludens-1 OCCLUDIN nuclear factor-kappa B 
Reduced expression of semaphorin 3A in osteoclasts causes lymphatic expansion in a Gorham-Stout disease(GSD)mouse model
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第1期38-50,共13页Dongfang ZHANG Hao XU Chi QIN Kangming CAI Jing ZHANG Xinqiu XIA Jingwen BI Li ZHANG Lianping XING Qianqian LIANG Wensheng WANG 
supported by the National Natural Science Foundation of China(No.81974321);the Discipline Innovation and Talent Introduction Program to Universities from Ministry of Education of China(Project 111);the Tackling Project for Science and Technology of Xinxiang City(No.GG2019003);the Natural Science Foundation of Henan Province of China(No.212300410173);the State Administration of Traditional Chinese Medicine Young Qi Huang Scholar,and the Innovation Team Project of Scientific Research of Traditional Chinese Medicine of Shanghai Health Committee(No.2022CX001);China.
Gorham-Stout disease(GSD)is a sporadic chronic disease characterized by progressive bone dissolution,absorption,and disappearance along with lymphatic vessel infiltration in bone-marrow cavities.Although the osteolyti...
关键词:Semaphorin 3A Gorham-Stout disease OSTEOCLAST OSTEOLYSIS Lymphatic endothelial cell 
Long noncoding RNA H19 regulates degeneration and regeneration of injured peripheral nerves被引量:2
《Neural Regeneration Research》2023年第8期1847-1851,共5页Yu-Mei Feng Jian Shao Min Cai Yi-Yue Zhou Yi Yao Jia-Xi Qian Zi-Han Ding Mao-Rong Jiang Deng-Bing Yao 
supported by the National Natural Science Foundation of China,Nos.31971277(to DBY),31950410551(to DBY);Scientific Research Foundation for Returned Scholars,Ministry of Education of China(to DBY);a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)(to DBY);the Postgraduate Research&Practice Innovation Program of Jiangsu Province of China,No.KYCX 19-2050(to JS);Jiangsu College Students’Innovation and Entrepreneurship Training Program,No.202213993005Y(to YY)。
Our previous studies have shown that long noncoding RNA(lncRNA)H19 is upregulated in injured rat sciatic nerve during the process of Wallerian degeneration,and that it promotes the migration of Schwann cells and slows...
关键词:adeno-associated virus dorsal root ganglion lncRNA H19 nerve degeneration nerve regeneration peripheral nerve rat sciatic nerve injury semaphorin 6D Wallerian degeneration 
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