目的研究细胞程序性死亡配体-1(programmed cell death protein ligand-1,PD-L1)功能抑制调控免疫活化影响ApoE^(-/-)小鼠动脉粥样硬化发生发展的机制。方法将24只ApoE^(-/-)小鼠随机分为正常组,高脂组和高脂^(+)抗PD-L1单抗组,通过高...
supported by the National Natural Science Foundation of China(No.82330114 to QJH,and No.82273949 to LD).
Tumor cells are characterized by rapid proliferation.In order to provide purines for DNA and RNA synthesis,inosine 5’-monophosphate dehydrogenase(IMPDH),a key enzyme in the de novo guanosine biosynthesis,is highly ex...
To the Editor:Immune checkpoint inhibitors(ICIs)interact with critical factors involved in immunoregulation.Following the FDA approval of nivolumab as a second line therapy for unresectable hepatocellular carcinoma(HC...