FAM111B基因在卵巢癌肿瘤免疫微环境中作用的研究进展  

Advances in the Role of FAM111B Gene in Immune Microenvironment of Ovarian Cancer

作　　者：李婉莹 韦芳 张莉红 Li Wanying;Wei Fang;Zhang Lihong(Department of Oncology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院肿瘤科,武汉430030

出　　处：《华中科技大学学报(医学版)》2025年第2期261-266,共6页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目(No.81803009);湖北省自然科学基金资助项目(No.2024AFB995);湖北陈孝平科技发展基金资助项目(No.CXPJJH122006-1027)。

摘　　要：卵巢癌是女性生殖系统最常见的恶性肿瘤之一,其死亡率位居妇科肿瘤之首。肿瘤免疫微环境由肿瘤微环境内的免疫成分组成,这些成分与肿瘤的发展和转移密切相关。卵巢癌是免疫“冷肿瘤”,因为它能产生免疫抑制性的肿瘤免疫微环境。由于卵巢癌肿瘤免疫微环境的特点,免疫治疗对卵巢癌的疗效有限。具有序列相似性111的家族成员B(family with sequence similarity 111 member B,FAM111B)蛋白的表达与多种肿瘤的发生发展以及肿瘤免疫微环境有关,也与卵巢癌组织中程序性死亡配体-1(programmed death ligand-1,PD-L1)的表达有关。该文就FAM111B对卵巢癌肿瘤免疫微环境影响的相关研究进展作一综述。Ovarian cancer(OC)is a prevalent malignant gynecological tumor with a high mortality rate.The tumor immune microenvironment,consisting of immune components within the tumor microenvironment,plays a significant role in tumor development and metastasis.OC is typically categorized as a"cold tumor"due to its immunosuppressive microenvironment,resulting in limited efficacy of immunotherapy for this disease.Specifically,the expression of family with sequence similarity 111 member B(FAM111B)protein has been found to be correlated with the immune microenvironment of various tumors,including its association with the expression of programmed death ligand-1(PD-L1)in ovarian cancer tissues.This review provides an overview of recent research developments concerning the impact of the FAM111B gene on the immune microenvironment of ovarian cancer.

关 键 词：卵巢癌 FAM111B 肿瘤免疫微环境 PD-L1 免疫治疗 

分 类 号：R737.31[医药卫生—肿瘤]