supported by the National Natural Science Foundation of China(No.82330114 to QJH,and No.82273949 to LD).
Tumor cells are characterized by rapid proliferation.In order to provide purines for DNA and RNA synthesis,inosine 5’-monophosphate dehydrogenase(IMPDH),a key enzyme in the de novo guanosine biosynthesis,is highly ex...
funded by National Natural Science Foundation of China(grant numbers:81872335,82303891 and 82303119);The Central Plains Science and Technology Innovation Leading Talents(No.224200510015,China);Key scientific research project plan of colleges and universities in Henan Province(grant number:24A310025,China);Science and Technology Project of Henan Province(No.242102310414,China).
Esophageal squamous cell carcinoma(ESCC),a malignancy of the digestive system,is highly prevalent and the primary cause of cancer-related deaths worldwide due to the lack of early diagnostic biomarkers and effective t...
supported by the National Natural Science Foundation of China Project(No.82072108,82192880,82192882,81830061,91740114 and 32000879);the Space Medical Experiment Project of China Manned Space Program(HYZHXM01006);National Key Laboratory of Space Medicine,China Astronaut Research and Training Center(SMFA22Q02)。
Bone marrow mesenchymal stem cell(BMSC)osteogenic differentiation and osteoblast function play critical roles in bone formation,which is a highly regulated process.Long noncoding RNAs(lncRNAs)perform diverse functions...