OSTEOCLAST

作品数：150被引量：727H指数：14
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相关作者：谭艳辉刘晓光邹斌华刘磊汤浩更多>>
相关机构：北京大学南方医科大学广西医科大学南方医科大学第三附属医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金上海市教育委员会重点学科基金更多>>
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RNA interference-mediated osteoprotegerin silencing increases the receptor activator of nuclear factor-kappa B ligand/osteoprotegerin ratio and promotes osteoclastogenesis
《World Journal of Stem Cells》2025年第4期64-78,共15页Song-Guan Wei Hui-Hong Chen Liu-Rong Xie Yuan Qin Yu-Ying Mai Lin-Hui Huang Hong-Bing Liao 
Supported by the National Natural Science Foundation of China,No.82160192;and Guangxi Science and Technology Program,No.2023AB23037.
BACKGROUND In vivo degradation of bone scaffolds is significantly influenced by osteoclast(OC)activity,which is orchestrated by the interplay between receptor activator of nuclear factor-kappa B ligand(RANKL)and osteo...
关键词：OSTEOPROTEGERIN Receptor activator of nuclear factor-kappa B ligand Bone marrow-derived mesenchymal stem cells RNA interference OSTEOCLAST Bone scaffold 
Naked cuticle homolog 2 controls the differentiation of osteoblasts and osteoclasts and ameliorates bone loss in ovariectomized mice
《Genes & Diseases》2025年第1期281-297,共17页Liying Shan Xiaoxia Liao Xiaoli Yang Endong Zhu Hairui Yuan Jie Zhou Xiaoxia Li Baoli Wang 
funded by the National Natural Science Foundation of China(No.82072389,82272444,81972033).
Naked cuticle homolog 2(NKD2)has been recognized as an antagonist of Wnt/β-catenin signaling and a tumor suppressor.The role of NKD2 in osteoblast and osteoclast differentiation and the mechanism are not fully unders...
关键词：Mechanistictargetof rapamycincomplex1 Naked cuticle homolog 2 OSTEOBLAST OSTEOCLAST Receptoractivatorof nuclearfactorkB ligand WNT/Β-CATENIN 
Buqi-Tongluo Decoction inhibits osteoclastogenesis and alleviates bone loss in ovariectomized rats by attenuating NFATc1,MAPK,NF-κB signaling
《Chinese Journal of Natural Medicines》2025年第1期90-101,共12页Yongxian Li Jinbo Yuan Wei Deng Haishan Li Yuewei Lin Jiamin Yang Kai Chen Heng Qiu Ziyi Wang Vincent Kuek Dongping Wang Zhen Zhang Bin Mai Yang Shao PanKang Qiuli Qin Jinglan Li Huizhi Guo Yanhuai Ma Danqing Guo Guoye Mo YijingFang Renxiang Tan Chenguang Zhan Teng Liu Guoning Gu Kai Yuan Yongchao Tang DeLiang Liangliang Xu Jiake Xu Shuncong Zhang 
supported by the Natural Science Foundation of Guangdong Province,China(No.2021A1515012168);the Administration of Traditional Chinese Medicine of Guangdong Province,China(Nos.20221146 and 20241091);the Basic and Applied Basic Research Fund Project in Guangdong Province,China(No.2020A1515110948);the Basic and Applied Basic Research in Jointly Funded Projects of City Schools(Institutes)Projects,China(Nos.202201020500 and 202201020295);the Project of Guangzhou Science and Technology Department,China(No.202102021040);the Guangzhou Science and Technology Plan Project,China(No.2023B03J0379);the Chinese Society of Traditional Chinese Medicine Youth Talent Lifting Project(No.2022-QNRC2-B11);the Hospital Young and Middle-aged Key Talent Cultivation Project of The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine(2023-10)。
Osteoporosis is a prevalent skeletal condition characterized by reduced bone mass and strength,leading to increased fragility.Buqi-Tongluo(BQTL)decoction,a traditional Chinese medicine(TCM)prescription,has yet to be f...
关键词：OSTEOPOROSIS Estrogen deficiency OSTEOCLAST Buqi-Tongluo NFATc1 MAPK NF-ΚB 
Beyond resorption:osteoclasts as drivers of bone formation
《Cell Regeneration》2024年第1期125-149,共25页Qianfeng Xiang Lei Li Wei Ji Debby Gawlitta X Frank Walboomers Jeroen J.J.P.van den Beucken 
China Scholarship Council(File No.202206270002).
Emerging evidence illustrates that osteoclasts(OCs)play diverse roles beyond bone resorption,contributing signifi-cantly to bone formation and regeneration.Despite this,OCs remain mysterious cells,with aspects of thei...
关键词：OSTEOCLAST Osteoclatogenesis Osteoclast characterization Angiogenesis regulation Bone formation Bone regeneration 
Targeting tumour-osteoclast interactions:a trigger-explosion system to combat bone metastasis被引量：1
《Biomaterials Translational》2024年第3期328-330,共3页Ang Gao Huaiyu Wang 
supported by the National Natural Science Foundation of China(No.82001965).
Cancer remains one of the leading causes of death worldwide,and tumour metastasis is responsible for more than 90%of cancer deaths.1,2 Bone is recognised as the most common site for metastasis of numerous malignancies...
关键词：metastasis ORGANS DEATH 
MOTS-c is an effective target for treating cancer-induced bone pain through the induction of AMPK-mediated mitochondrial biogenesis
《Acta Biochimica et Biophysica Sinica》2024年第9期1323-1339,共17页Long Yang Miaomiao Li Yucheng Liu Yang Bai Tianyu Yin Yangyang Chen Jinhong Jiang Su Liu 
supported by the grants from the National Natural Science Foundation of China(No.82201385);the Natural Science Research Fund of Higher Education Institutions in Jiangsu Province(No.22KJA320007);the Science and Technology Project of Xuzhou Health Commission(No.XWKYHT20230056).
Bone cancer pain(BCP),due to cancer bone metastasis and bone destruction,is a common symptom of tumors,including breast,prostate,and lung tumors.Patients often experience severe pain without effective treatment.Here,u...
关键词：MoTS-c AMPK bone cancer pain MITOCHONDRIAL OSTEOCLAST 
Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor
《Bone Research》2024年第3期571-581,共11页Hideyuki Kobayashi M.Alaa Terkawi Masahiro Ota Tomoka Hasegawa Tomomaya Yamamoto Tomohiro Shimizu Dai Sato Ryo Fujita Toshifumi Murakami Norio Amizuka Norimasa Iwasaki Masahiko Takahata 
supported by a Grant-in-Aid for Exploratory Research from the Ministry of Education,Culture,Sports,Science,and Technology of Japan 17H04309 (MT);the Mitsubishi foundation。
DNAX-associated protein 12 kD size(DAP12)is a dominant immunoreceptor tyrosine-based activation motif(ITAM)-signaling adaptor that activates costimulatory signals essential for osteoclastogenesis.Although several DAP1...
关键词：REMODELING OSTEOCLAST stimulating 
SUV39H1-driven NFATc1 methylation is essential for the c-Cbl-mediated degradation of NFATc1 in an osteoclast lineage
《Genes & Diseases》2024年第4期86-89,共4页Do-Won Jeong Hye-Jin Kim Jong-Wan Park Seulbee Lee Hyeryeon Jung Eugene C.Yi Nacksung Kime Yang-Sook Chun 
supported by the National Research Foundation of Korea(No.2019R1A2C2083886,2018R1A5A20-25964);supported by the Cooperative Research Program of Basic Medical Science and Clinical Science from Seoul National University College of Medicine(No.800-20220312).
Bone undergoes continuous remodeling by tightly-coordinated actions of bone-resorbing osteoclasts and boneforming osteoblasts.1 Recent studies document that the dysregulation of histone methylation profiles is associa...
关键词：OSTEOCLAST REMODELING INCOMPLETE 
The role of lipid metabolism in osteoporosis:Clinical implication and cellular mechanism被引量：1
《Genes & Diseases》2024年第4期220-233,共14页Jing Zhang Wenhui Hu Zhi Zou Yuheng Li Fei Kang Jianmei Li Shiwu Dong 
sponsored by the Key Program of the National Natural Science Foundation of China(No.81930067);the Natural Science Foundation of China(No.82002316);the Youth Cultivation Project of Army Medical University(China)(No.2020XQN08).
In recent years,researchers have become focused on the relationship between lipids and bone metabolism balance.Moreover,many diseases related to lipid metabolism dis-orders,such as nonalcoholic fatty liver disease,ath...
关键词：Bone homeostasis Cross-organ communication Lipid metabolism OSTEOCLAST OSTEOPOROSIS 
The roles of extracellular vesicles released by mechanically stimulated osteocytes in regulating osteoblast and osteoclast functions
《Mechanobiology in Medicine》2024年第2期71-78,共8页Yumei Chen Runze Zhao Li Yang X.Edward Guo 
Bone adapts to mechanical loading by changing its shape and mass.Osteocytes,as major mechanosensors,are critical for bone modeling/remodeling in response to mechanical stimuli.Intracellular calcium oscillation is one ...
关键词：OCY454 OSTEOCYTE MECHANOTRANSDUCTION Fluid flow Extracellular vesicles 
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