MECHANOTRANSDUCTION

作品数：93被引量：191H指数：8
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Mechanosensitive adhesion G protein-coupled receptors: Insights from health and disease
《Genes & Diseases》2025年第3期93-107,共15页Shiying Sun Wen Wang 
supported by grants from the Natural Science Foundation of Hebei Province(China)(No.H2020206226);Hebei Province Science and Technology Support Program(China)(No.18277756D);the Science and Technology Research Project of Hebei Higher Education Institutions(China)(No.ZD2022010);High-level talent funding project of Hebei(China)(No.20231141)to W.W.
Ontogeny cannot be separated from mechanical forces. Cells are continuously subjected to different types of mechanical stimuli that convert into intracellular signals throughmechanotransduction. As a member of the G p...
关键词：Activation mechanism aGPCR Health and disease MECHANOTRANSDUCTION Signaling pathway 
Biological processes involved in mechanical force transmission in connective tissue:Linking bridges for new therapeutic applications in the rehabilitative field
《BIOCELL》2025年第1期1-5,共5页AUGUSTO FUSCO STEFANO BONOMI LUCA PADUA 
Connective tissue is a dynamic structure that reacts to environmental cues to maintain homeostasis,including mechanical properties.Mechanical load influences extracellular matrix(ECM)—cell interactions and modulates ...
关键词：Connective tissue Cellular mechanotransduction INTEGRINS Translational science 
miRNA in mechanobiology:The exploration needs to continue
《Mechanobiology in Medicine》2024年第4期1-3,共3页Kai Huang Yingxin Qi 
supported by grants from the National Natural Science Foundation of China(grant numbers 12032003,12302409).
The 2024 Nobel Prize in Physiology or Medicine has once again sparked considerable interest in microRNA(miRNA).Recent advances have unveiled that miRNAs play critical roles in mediating the effects of mechanical stimu...
关键词：MECHANOTRANSDUCTION microRNA(miRNAs) Mechanical stress 
YAP/TAZ as mechanobiological signaling pathway in cardiovascular physiological regulation and pathogenesis
《Mechanobiology in Medicine》2024年第4期32-44,共13页Rakibul Islam Zhongkui Hong 
supported,in part,by the National Science Foundation Grant 2304667(to Z.H.);the National Institutes of Health Grant 7 R15 HL147214-02(to Z.H.).
Cardiovascular diseases(CVDs)persistently rank as a leading cause of premature death and illness worldwide.The Hippo signaling pathway,known for its highly conserved nature and integral role in regulating organ size,t...
关键词：HIPPO YAP/TAZ Cardiovascular diseases MECHANOTRANSDUCTION Signaling 
Cancer cell response to extrinsic and intrinsic mechanical cue:opportunities for tumor apoptosis strategies
《Regenerative Biomaterials》2024年第6期1-19,共19页Jun Shu Huan Deng Yu Zhang Fang Wu Jing He 
supported by the National Natural Science Foundation of China(grant no.31971257);Natural Science Foundation of Sichuan Province(grant no.2022NSFSC0360).
Increasing studies have revealed the importance of mechanical cues in tumor progression,invasiveness and drug resistance.During malignant transformation,changes manifest in either the mechanical properties of the tiss...
关键词：MECHANOTRANSDUCTION cancer cell APOPTOSIS mechanical stimulation anticancer materials 
In vivo analysis of hybrid hydrogels containing dual growth factor combinations,and skeletal stem cells under mechanical stimulation for bone repair
《Mechanobiology in Medicine》2024年第4期97-109,共13页David Gothard Michael Rotherham Emma L.Smith Janos M.Kanczler James Henstock Julia A.Wells Carol A.Roberts Omar Qutachi Heather Peto Hassan Rashidi Luis Rojo Lisa J.White Molly M.Stevens Alicia J.El Haj Felicity R.J.ose Richard O.C.Oreffo 
supported by the BBSRC(sLOLA grant BB/G010579/1);an EU ERC Advanced Grant DYNACEUTICS(grant no.789119).
Bone tissue engineering requires a combination of materials,cells,growth factors and mechanical cues to recapitulate bone formation.In this study we evaluated hybrid hydrogels for minimally invasive bone formation by ...
关键词：Growth factors Controlled release Bone ECM Bone formation MECHANOTRANSDUCTION Skeletal stem cell 
Mechanism and application of feedback loops formed by mechanotransduction and histone modifications被引量：1
《Genes & Diseases》2024年第5期198-218,共21页Han Sun Yafang Gao Xinyu Ma Yizhou Deng Lintao Bi Lisha Li 
the Department of Science and Technology of Jilin Province,China(No.20230101163JC and No.20210509003RQ)。
Mechanical stimulation is the key physical factor in cell environment.Mechanotransduction acts as a fundamental regulator of cell behavior,regulating cell proliferation,differentiation,apoptosis,and exhibiting specifi...
关键词：FAK Histone modifications MAPK MECHANOTRANSDUCTION RHOA WNT/b-catenin YAP/TAZ 
Creating a bionic scaffold via light-curing liquid crystal ink to reveal the role of osteoid-like microenvironment in osteogenesis
《Bioactive Materials》2024年第10期244-260,共17页Kun Liu Lin Li Yizhi Li Yiting Luo Zhaoyu Zhang Wei Wen Shan Ding Yadong Huang Mingxian Liu Changren Zhou Binghong Luo 
supported by the National Natural Science Foundation of China(31771047);Guangdong Provincial Natural Science Foundation of China(2022A1515010592and 2023A1515010107);Guangdong Provincial Key Areas R&D Programs(2022B1111080007);the Key Areas Research and Development Program of Guangzhou(202103030003);the Outstanding Innovative Talents Cultivation Funded Programs for Doctoral Students of Jinan University(2023CXB013).
Osteoid plays a crucial role in directing cell behavior and osteogenesis through its unique characteristics,including viscoelasticity and liquid crystal(LC)state.Thus,integrating osteoid-like features into 3D printing...
关键词：3D printing Digital light process Liquid crystal hydrogel scaffolds High protein clustering Tunable mechanotransduction Synergistic osteogenesis 
Advances in micropatterning technology for mechanotransduction research
《Mechanobiology in Medicine》2024年第3期31-39,共9页Xinyu Hu Min Bao 
supported by start-up funding(grant OJQD2022015)from Oujiang Laboratory;the National Natural Science Foundation of China(grant 82301873).
Micropatterning is a sophisticated technique that precisely manipulates the spatial distribution of cell adhesion proteins on various substrates across multiple scales.This precise control over adhesive regions facili...
关键词：MECHANOTRANSDUCTION MICROPATTERNING Organoid Cell geometry Cell differentiation Tissue engineering 
Mechanoluminescent Materials Enable Mechanochemically Controlled Atom Transfer Radical Polymerization and Polymer Mechanotransduction
《Research》2024年第3期97-104,共8页Zexuan Li Zhenhua Wang Chen Wang Wenxi Li Wenru Fan Ruoqing Zhao Haoyang Feng Dengfeng Peng Wei Huang 
the National Key Research and Development Program of China(2020YFB2008501);the National Natural Science Foundation of China(21901207);Shaanxi Science and Technology Fund(2020JQ-137)for financial support.
Organic mechanophores have been widely adopted for polymer mechanotransduction.However,most examples of polymer mechanotransduction inevitably experience macromolecular chain rupture,and few of them mimic mussel’s me...
关键词：chemically POLYMERIZATION LUMINESCENT 
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