YAP/TAZ as mechanobiological signaling pathway in cardiovascular physiological regulation and pathogenesis  

作　　者：Rakibul Islam Zhongkui Hong 

机构地区：[1]Department of Mechanical Engineering,Texas Tech University,Lubbock,TX 79409,USA

出　　处：《Mechanobiology in Medicine》2024年第4期32-44,共13页力学生物学与医学（英文）

基　　金：supported,in part,by the National Science Foundation Grant 2304667(to Z.H.);the National Institutes of Health Grant 7 R15 HL147214-02(to Z.H.).

摘　　要：Cardiovascular diseases(CVDs)persistently rank as a leading cause of premature death and illness worldwide.The Hippo signaling pathway,known for its highly conserved nature and integral role in regulating organ size,tissue homeostasis,and stem cell function,has been identified as a critical factor in the pathogenesis of CVDs.Recent findings underscore the significance of the Yes-associated protein(YAP)and the Transcriptional Coactivator with PDZ-binding motif(TAZ),collectively referred to as YAP/TAZ.These proteins play pivotal roles as downstream components of the Hippo pathway,in the regulation of cardiovascular development and homeostasis.YAP/TAZ can regulate various cellular processes such as cell proliferation,migration,differentiation,and apoptosis through their interactions with transcription factors,particularly those within the transcriptional enhancer associate domain(TEAD)family.The aim of this review is to provide a comprehensive overview of the current understanding of YAP/TAZ signaling in cardiovascular physiology and pathogenesis.We analyze the regulatory mechanisms of YAP/TAZ activation,explore their downstream effectors,and examine their association across numerous cardiovascular disorders,including myocardial hypertrophy,myocardial infarction,pulmonary hypertension,myocardial ischemia-reperfusion injury,atherosclerosis,angiogenesis,restenosis,and cardiac fibrosis.Furthermore,we investigate the potential therapeutic implications of targeting the YAP/TAZ pathway for the treatment of CVDs.Through this comprehensive review,our aim is to elucidate the current understanding of YAP/TAZ signaling in cardiovascular biology and underscore its potential implications for the diagnosis and therapeutic intervention of CVDs.

关 键 词：HIPPO YAP/TAZ Cardiovascular diseases MECHANOTRANSDUCTION Signaling 

分 类 号：R318[医药卫生—生物医学工程]