Cancer cell response to extrinsic and intrinsic mechanical cue:opportunities for tumor apoptosis strategies  

作　　者：Jun Shu Huan Deng Yu Zhang Fang Wu Jing He 

机构地区：[1]National Engineering Research Center for Biomaterials,College of Biomedical Engineering,Sichuan University,Chengdu 610064,PR China [2]College of Food and Biological Engineering,Chengdu University,Chengdu 610106,PR China

出　　处：《Regenerative Biomaterials》2024年第6期1-19,共19页再生生物材料(英文版)

基　　金：supported by the National Natural Science Foundation of China(grant no.31971257);Natural Science Foundation of Sichuan Province(grant no.2022NSFSC0360).

摘　　要：Increasing studies have revealed the importance of mechanical cues in tumor progression,invasiveness and drug resistance.During malignant transformation,changes manifest in either the mechanical properties of the tissue or the cellular ability to sense and respond to mechanical signals.The major focus of the review is the subtle correlation between mechanical cues and apoptosis in tumor cells from a mechanobiology perspective.To begin,we focus on the intracellular force,examining the mechanical properties of the cell interior,and outlining the role that the cytoskeleton and intracellular organelle-mediated intracellular forces play in tumor cell apoptosis.This article also elucidates the mechanisms by which extracellular forces guide tumor cell mechanosensing,ultimately triggering the activation of the mechanotransduction pathway and impacting tumor cell apoptosis.Finally,a comprehensive examination of the present status of the design and development of anti-cancer materials targeting mechanotransduction is presented,emphasizing the underlying design principles.Furthermore,the article underscores the need to address several unresolved inquiries to enhance our comprehension of cancer therapeutics that target mechanotransduction.

关 键 词：MECHANOTRANSDUCTION cancer cell APOPTOSIS mechanical stimulation anticancer materials 

分 类 号：R73[医药卫生—肿瘤]