Mechanosensitive adhesion G protein-coupled receptors: Insights from health and disease  

作　　者：Shiying Sun Wen Wang 

机构地区：[1]Department of Orthodontics,School and Hospital of Stomatology,Hebei Medical University,Shijiazhuang,Hebei 050017,China [2]Hebei Key Laboratory of Stomatology,School and Hospital of Stomatology,Hebei Medical University,Shijiazhuang,Hebei 050017,China [3]Hebei Clinical Research Center for Oral Diseases,School and Hospital of Stomatology,Hebei Medical University,Shijiazhuang,Hebei 050017,China

出　　处：《Genes & Diseases》2025年第3期93-107,共15页基因与疾病(英文)

基　　金：supported by grants from the Natural Science Foundation of Hebei Province(China)(No.H2020206226);Hebei Province Science and Technology Support Program(China)(No.18277756D);the Science and Technology Research Project of Hebei Higher Education Institutions(China)(No.ZD2022010);High-level talent funding project of Hebei(China)(No.20231141)to W.W.

摘　　要：Ontogeny cannot be separated from mechanical forces. Cells are continuously subjected to different types of mechanical stimuli that convert into intracellular signals throughmechanotransduction. As a member of the G protein-coupled receptor superfamily, adhesion Gprotein-coupled receptors (aGPCRs) have attracted extensive attention due to their uniqueextracellular domain and adhesion properties. In the past few decades, increasing evidencehas indicated that sensing mechanical stimuli may be one of the main physiological activitiesof aGPCRs. Here, we review the general structure and activation mechanisms of these receptors and highlight the lesion manifestations relevant to each mechanosensitive aGPCR.

关 键 词：Activation mechanism aGPCR Health and disease MECHANOTRANSDUCTION Signaling pathway 

分 类 号：R363[医药卫生—病理学]