OSTEOCYTE

作品数：28被引量：99H指数：5
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相关领域：医药卫生更多>>
相关机构：重庆医科大学复旦大学青岛大学更多>>
相关期刊：《Mechanobiology in Medicine》《医用生物力学》《Medicine in Novel Technology and Devices》《Bioactive Materials》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis
《Bone Research》2025年第1期151-169,共19页Yewei Jia Rui Li Yixuan Li Katerina Kachler Xianyi Meng Andreas Gießl Yi Qin Fulin Zhang Ning Liu Darja Andreev Georg Schett Aline Bozec 
funding from the European Research Council(ERC)under the european union Horizon 2020 research and innovation program(grant agreement ERC co-LS4 ODE(AB)and ERC Synergy Grant 4D Nanoscope(GS));Deutsche Forschungsgemeinschaft DFG-Project number 501752319-TRR369-DIONE-Project No A02 and B05,FOR 2886(TP02),CRC1181(TPA01);DFG funding(450993414)Thunder Imager and the Leibniz Award(GS)。
Osteocytes are the main cells in mineralized bone tissue.Elevated osteocyte apoptosis has been observed in lytic bone lesions of patients with multiple myeloma.However,their precise contribution to bone metastasis rem...
关键词：HIF1Α METASTASIS HMO 
Low-magnitude high-frequency vibration reduces prostate cancer growth and extravasation in vitro
《Mechanobiology in Medicine》2024年第4期83-96,共14页Amel Sassi Kimberly Seaman Xin Song Chun-Yu Lin Yu Sun Lidan You 
supported by the Natural Science and Engineering Research Council(NSERC,Grant No:06465-14).
Prostate cancer(PCa)continues to rank among the most common malignancies in Europe and North America with significant mortality rates despite advancements in detection and treatment.Physical activity is often recommen...
关键词：Low-magnitude high-frequency vibration Mechanical loading Vibration Prostate cancer Bone metastasis OSTEOCYTE Microfluidic SPHEROID 
Biomechanical analysis of an osteocyte model by considering bone matrix’s piezoelectricity
《Acta Mechanica Sinica》2024年第9期131-148,共18页Xiyu Wang Zhengbiao Yang Yanru Xue Yixian Qin Meng Zhang Jing Chen Pengcui Li Xiaochun Wei Haoyu Feng Liming He Yanqin Wang Xiaogang Wu Weiyi Chen 
supported by the National Natural Science Foundation of China(Grant Nos.12272250,12372310,and 82172503);China Postdoctoral Science Foundation(Grant No.2020M680913);Shanxi Scholarship Council of China(Grant No.2022081);Shanxi Province Graduate Education Innovation Program(Grant Nos.2022Y278 and 2023-125).
Osteocytes,the primary cells in bone,play a crucial role in sensing external load environments and regulating other bone cells.Due to the piezoelectric effect of the mineralized matrix and collagen that make up bone,t...
关键词：OSTEOCYTE Primary cilia Cell process Collagen hillock Piezoelectric effect 
The roles of extracellular vesicles released by mechanically stimulated osteocytes in regulating osteoblast and osteoclast functions
《Mechanobiology in Medicine》2024年第2期71-78,共8页Yumei Chen Runze Zhao Li Yang X.Edward Guo 
Bone adapts to mechanical loading by changing its shape and mass.Osteocytes,as major mechanosensors,are critical for bone modeling/remodeling in response to mechanical stimuli.Intracellular calcium oscillation is one ...
关键词：OCY454 OSTEOCYTE MECHANOTRANSDUCTION Fluid flow Extracellular vesicles 
Rescuing SERCA2 pump deficiency:A novel approach to improve bone mechano-responsiveness in type 2 diabetes
《Mechanobiology in Medicine》2024年第2期1-3,共3页Zhifeng Yu X.Edward Guo 
A recent study published in Nature Communications demonstrated that restoring SERCA2 pump deficiency can enhance bone mechano-responsiveness in type 2 diabetes(T2D)by modulating osteocyte calcium dynamics.The findings...
关键词：SERCA2 pump Osteocyte calcium dynamics Calcium oscillatory MECHANOTRANSDUCTION 
The role of primary cilia in mechanical transmission of osteocyte based on a 3D finite element model
《Medicine in Novel Technology and Devices》2024年第1期31-38,共8页Zhuang Han Dong Ding Yu-bo Fan Xin-tong Wu Xiao Yang Lian-wen Sun 
National Natural Science Foundation of China(11972068,12002026).
The primary cilium,as a mechanical receptor of osteocytes,participates in the regulation of osteocyte mechanosensitivity.However,how the length of osteocyte primary cilia changes with fluid shear stress(FSS)are unclea...
关键词：Primary cilia Osteocyte model Finite element analysis MECHANOTRANSDUCTION 
Fragile X Messenger Ribonucleoprotein 1(FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice
《Bone Research》2023年第2期384-397,共14页Padmini Deosthale Julián Balanta-Melo Amy Creecy Chongshan Liu Alejandro Marcial Laura Morales Julita Cridlin Sylvia Robertson Chiebuka Okpara David J.Sanchez Mahdi Ayoubi Joaquín N.Lugo Christopher J.Hernandez Joseph M.Wallace Lilian I.Plotkin 
supported by the National Institutes of Health R01-AR053643;Veterans Research Administration Merit Award I01BX00515;a Research Support Funds Grant(RSFG),Indiana University Purdue University Indianapolis-Office of the Vice Chancellor for Research,Indianapolis to LIP.;supported by ASBMR Fund for Research and Education Research and Collaborative Grant Program;supported by the National Institutes of Health R01AG067997 to CJH;supported by the IUPUI Diversity Scholars Research Program(DSRP);Diversity Summer Undergraduate Research Opportunity Program(DS-UROP);Indiana CTSI Student Summer Research Program;IUPUI work study program;supported by the Life Health Science Internship(LHSI)。
Fragile X Messenger Ribonucleoprotein 1(FMR1)gene mutations lead to fragile X syndrome,cognitive disorders,and,in some individuals,scoliosis and craniofacial abnormalities.Four-month-old(mo)male mice with deletion of ...
关键词：female MESSENGER AGILE 
Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23被引量：2
《Bone Research》2023年第1期178-192,共15页Megan L.Noonan Pu Ni Emmanuel Solis Yamil G.Marambio Rafiou Agoro Xiaona Chu Yue Wang Hongyu Gao Xiaoling Xuei Erica L.Clinkenbeard Guanglong Jiang Sheng Liu Steve Stegen Geert Carmeliet William R.Thompson Yunlong Liu Jun Wan Kenneth E.White 
NIH grants F31-DK122679 and T32-HL007910(MLN);a postdoctoral research grant from the Research Foundation–Flanders(FWO/12H5917N)(SS);R01-AR074473(WRT);R21-AR059278,R01-DK112958,and R01-HL145528(KEW);The David Weaver Professorship(KEW);The Indiana University Melvin and Bren Simon Comprehensive Cancer Center FCRF is funded in part by NIH;National Cancer Institute(NCI)grant P30 CA082709;National Institute of Diabetes and Digestive and Kidney Diseases(NIDDK)grant U54DK106846;supported in part by NIH instrumentation grant 1S10D012270。
Osteocytes act within a hypoxic environment to control key steps in bone formation.FGF23,a critical phosphate-regulating hormone,is stimulated by low oxygen/iron in acute and chronic diseases,however the molecular mec...
关键词：FGF23 COLLECTIVE adapted 
A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis被引量：4
《Bioactive Materials》2023年第3期110-128,共19页Xiaofang Wang Yufei Ma Jie Chen Yujiao Liu Guangliang Liu Pengtao Wang Bo Wang Makoto M.Taketo Teresita Bellido Xiaolin Tu 
National Natural Science Foundation of China U1601220(X.T.),81672118(X.T.),82072450(X.T.),82002310(Y.M.);Chongqing Science and Technology Commission—Basic Science and Frontier Technology Key Project cstc2015jcyjBX0119(X.T.);CQMU Program for Youth Innovation in Future Medicine,W0075(Y.M.).
Cell source is the key to decellularized matrix(DM)strategy.This study compared 3 cell types,osteocytes with/without dominant active Wnt/β-catenin signaling(daCO and WTO)and bone marrow stromal cells(BMSCs)for their ...
关键词：Decellularized matrix OSTEOCYTE Wnt signaling 3D printing Regenerative repair Metabolic and neurovascular organoid bone 
Osteocyte pericellular and perilacunar matrices as markers of bone-implant mechanical integrity
《BIOCELL》2022年第10期2209-2216,共8页ReMY GAUTHIER HeLÈNE FOLLET ANA-MARIA TRUNFIO-SFARGHIU DELPHINE FARLAY NINA ATTIK SYLVAIN MEILLE JeRÔME CHEVALIER DAVID MITTON 
To develop durable bone healing strategies through improved control of bone repair,it is of critical importance to understand the mechanisms of bone mechanical integrity when in contact with biomaterials and implants....
关键词：Bone mechanical integrity OSTEOCYTES Pericellular Perilacunar MECHANOSENSITIVITY 
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